https://m2.mtmt.hu/ hun 2026-10-25 00:57 JournalArticle 31637565 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Fund, OTKA [K 132596]; Scientific Excellence Program 2019, at the University of Physical Education, Innovation and Technology Ministry, Hungary [TUDFO/51757/2019-ITM]; Higher Education Institutional Excellence Programme of the Ministry of Human Capacities, Hungary [20765-3/2018/FEKUTSTRAT FIKPII] Funding text: National Research, Development and Innovation Fund, OTKA K 132596, and Scientific Excellence Program 2019, at the University of Physical Education, Innovation and Technology Ministry, Hungary TUDFO/51757/2019-ITM, and the Higher Education Institutional Excellence Programme of the Ministry of Human Capacities, Hungary (20765-3/2018/FEKUTSTRAT FIKPII). 0 false 2026-10-20T20:30:14.181+0000 2024-11-28T05:55:55.974+0000 2020-10-22T07:06:27.298+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-08-27T12:21:04.564+0000 2024-11-28T05:55:56.416+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Cziráki, A. L-Arginine-Nitric Oxide-Asymmetric Dimethylarginine Pathway and the Coronary Circulation: Translation of Basic Science Results to Clinical Practice true true /api/journal/10026753 REVIEWED true false 10026753 false 10026753 true 1663-9812 Journal FOREIGN 11 569914 569914 20 2020 By 1980, it was thought that we already knew most of the major mechanisms regulating vascular tone. However, after the somewhat serendipity discovery that endothelium is involved in mediation of relaxation to acetylcholine, a whole new world opened up and we had to rewrite our concept regarding vascular function and its regulation (not to mention many other fields). The new player was an endothelium derived relaxing factor, which molecular constitution has been identified to be nitric oxide (NO). This review summarizes the major molecular steps concerning how NO is synthetized from L-arginine. Also, the fate of L-arginine is described via the arginase and methylation pathways; both of them are affecting substantially the level and efficacy of NO. In vitro and in vivo effects of L-arginine are summarized and controversial clinical findings are discussed. On the basis of the use of methylated L-arginines, the vasomotor effects of endothelial NO released to agonists and increases in flow/wall shear stress (a major biological stimulus) is summarized. In this review the role of NO in the regulation of coronary vascular resistance, hence blood flow, is delineated and the somewhat questionable clinical use of NO donors is discussed. We made an attempt to summarize the biosynthesis, role, and molecular mechanisms of endogenously produced methylated L-arginine, asymmetric dimethylarginine (ADMA) in modulating vascular resistance, affecting the function of the heart. Additionally, the relationship between ADMA level and various cardiovascular diseases is described, such as atherosclerosis, coronary artery disease (CAD), ischemia/reperfusion injuries, and different types of coronary revascularization. A novel aspect of coronary vasomotor regulation is identified in which the pericardial fluid ADMA and endothelin play putative roles. Finally, some of the open possibilities for future research on L-arginine-NO-ADMA signaling are highlighted. © Copyright © 2020 Cziráki, Lenkey, Sulyok, Szokodi and Koller. 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10016439"><a href="/gui2/?type=authors&mode=browse&sel=10016439" target="_blank">Cziráki A. ✉ (<span class="authorship-author-name">Cziráki Attila</span> <span class="authorAux-mtmt"> Az endotél diszfunkció artériás stiffness és bi...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szívgyógyászati Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Molekuláris Kardiológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021105"><a href="/gui2/?type=authors&mode=browse&sel=10021105" target="_blank">Lenkey Z. (<span class="authorship-author-name">Lenkey Zsófia</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szívgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001850"><a href="/gui2/?type=authors&mode=browse&sel=10001850" target="_blank">Sulyok E. (<span class="authorship-author-name">Sulyok Endre</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002279"><a href="/gui2/?type=authors&mode=browse&sel=10002279" target="_blank">Szokodi I. (<span class="authorship-author-name">Szokodi István</span> <span class="authorAux-mtmt"> Kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szívgyógyászati Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Molekuláris Kardiológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002221"><a href="/gui2/?type=authors&mode=browse&sel=10002221" target="_blank">Koller A. (<span class="authorship-author-name">Koller Ákos</span> <span class="authorAux-mtmt"> Szív és vérkeringés</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Morfológiai és Fiziológiai Tanszék; <span title="Testnevelési Egyetem">TE</span>/Természettudományi Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31637565" target="_blank">L-Arginine-Nitric Oxide-Asymmetric Dimethylarginine Pathway and the Coronary Circulation: Translation of Basic Science Results to Clinical Practice</a></div> <div> <span class="journal-title">FRONTIERS IN PHARMACOLOGY</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1663-9812">1663-9812</a>)</span>: <span class="journal-volume">11</span> <span class="page"> Paper 569914. 20 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fphar.2020.569914" target="_blank" href="https://doi.org/10.3389/fphar.2020.569914"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000578615800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000578615800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85092482186" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85092482186"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33117166" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33117166&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 56</span> | Független: 53 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 49 | Scopus jelölt:&nbsp;53 | WoS/Scopus jelölt:&nbsp;56 | DOI jelölt:&nbsp;56 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31637565&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 25 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31637565</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (20765-3/2018/FEKUTSRAT) Támogató: EMMI </div> <div class="lastModified">Utolsó módosítás: 2024.11.28. 06:55 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Research, Development and Innovation Fund, OTKA [K 132596]; Scientific Excellence Program 2019, at the University of Physical Education, Innovation and Technology Ministry, Hungary [TUDFO/51757/2019-ITM]; Higher Education Institutional Excellence Programme of the Ministry of Human Capacities, Hungary [20765-3/2018/FEKUTSTRAT FIKPII] Funding ...</pre> </div></div>