https://m2.mtmt.hu/ hun 2026-09-20 15:34 JournalArticle 31637235 VALIDATED true Drs Hoffmann and Neilan contributed equally 0 false 2026-09-16T08:36:42.284+0000 2023-12-14T09:31:10.799+0000 2020-10-21T13:54:45.519+0000 true 10061268 Drobni Zsófia /api/author/10061268 Author true 10061268 2024-10-08T07:26:05.942+0000 2024-10-08T07:26:05.942+0000 2023-11-27T10:49:26.478+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Drobni, Zsofia D Association Between Immune Checkpoint Inhibitors with Cardiovascular Events and Atherosclerotic Plaque true true /api/journal/1023 REVIEWED true false 1023 false 1023 true 0009-7322 1524-4539 Journal FOREIGN 142 24 2299 2311 2299 13 2020 Background: Immune checkpoint inhibitors (ICI) treat an expanding range of cancers. Consistent basic data suggest that these same checkpoints are critical negative regulators of atherosclerosis. Therefore, our objectives were to test whether ICIs were associated with accelerated atherosclerosis and a higher risk of atherosclerosis-related cardiovascular events. Methods: The study was situated in a single academic medical center. The primary analysis evaluated whether exposure to an ICI was associated with atherosclerotic cardiovascular events in 2842 patients and 2842 controls, matched by age, a history of cardiovascular events and cancer type. In a second design, a case-crossover analysis was performed with an "at-risk period" defined as the two-year period after and the "control period" as the two-year prior to treatment. The primary outcome was a composite of atherosclerotic cardiovascular events (myocardial infarction, coronary revascularization and ischemic stroke). Secondary outcomes included the individual components of the primary outcome. Additionally, in an imaging sub-study (n=40), the rate of atherosclerotic plaque progression was compared from before and after starting an ICI. All study measures and outcomes were blindly adjudicated. Results: In the matched cohort study, there was a 3-fold higher risk for cardiovascular events after starting an ICI (HR, 3.3 [95% CI, 2.0-5.5]; P<0.001). There was a similar increase in each of the individual components of the primary outcome. In the case-crossover, there was also an increase in cardiovascular events from 1.37 to 6.55 per 100 person-years at two years (adjusted HR, 4.8 [95% CI, 3.5-6.5]; P<0.001). In the imaging study, the rate of progression of total aortic plaque volume was >3-fold higher with ICIs (from 2.1%/year pre-to 6.7%/year post). This association between ICI use and increased atherosclerotic plaque progression was attenuated with concomitant use of statins or corticosteroids. Conclusions: Cardiovascular events were higher after initiation of ICIs, potentially mediated by accelerated progression of atherosclerosis. Optimization of cardiovascular risk factors and increased awareness of cardiovascular risk, prior to, during and after treatment, should be considered among patients on an ICI. true true 2020 true true true false true false PAY 2026-09-16 false 484 0 484 439 16 483 481 457 450 484 484 439 439 439 45 0 484 439 484 439 0 0 0 Folyóiratcikk Journal Article 24 481 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 4 3 4 3 2021 0 54 41 54 41 2022 0 92 85 92 85 2023 0 93 80 93 80 2024 0 91 88 91 88 2025 0 111 109 111 109 2026 0 39 33 39 33 D1 false 10061268 false false false 2020-12-27T08:37:54.525+0000 Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); MTA-SE Lendület Kardiovaszkuláris Képalkotó Kut... 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33003973 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33003973&dopt=Abstract false true SjrRating 10758715 /api/sjrrating/10758715 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/31637235 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10061268"><a href="/gui2/?type=authors&mode=browse&sel=10061268" target="_blank">Drobni Zsofia D (<span class="authorship-author-name">Drobni Zsófia</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/MTA-SE Lendület Kardiovaszkuláris Képalkotó Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Alvi Raza M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Taron Jana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zafar Amna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Murphy Sean P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rambarat Paula K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mosarla Ramya C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lee Charlotte </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zlotoff Daniel A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Raghu Vineet K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hartmann Sarah E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gilman Hannah K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gong Jingyi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zubiri Leyre </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sullivan Ryan J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reynolds Kerry L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mayrhofer Thomas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhang Lili </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoffmann Udo<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Neilan Tomas G ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31637235" target="_blank">Association Between Immune Checkpoint Inhibitors with Cardiovascular Events and Atherosclerotic Plaque</a></div> <div> <span class="journal-title">CIRCULATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0009-7322">0009-7322</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1524-4539">1524-4539</a>)</span>: <span class="journal-volume">142</span> <span class="journal-issue">24</span> <span class="page"> pp 2299-2311 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1161/CIRCULATIONAHA.120.049981" target="_blank" href="https://doi.org/10.1161/CIRCULATIONAHA.120.049981"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000639226400006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000639226400006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85097939929" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85097939929"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33003973" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33003973&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 484</span> | Független: 439 | Függő: 45 | Nem jelölt: 0 | WoS jelölt: 457 | Scopus jelölt:&nbsp;450 | WoS/Scopus jelölt:&nbsp;484 | DOI jelölt:&nbsp;481 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31637235</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2023.12.14. 10:31 Berhidi Anna (SE_KK_Admin5_BA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Drs Hoffmann and Neilan contributed equally</pre> </div></div>