https://m2.mtmt.hu/ hun 2026-09-23 09:49 JournalArticle 31627448 ADMIN_APPROVED true Endocrinology Institute, Gertner Institute, Sheba Medical Center, Ramat-Gan, Israel Epidemiology Department, Sackler School of Medicine, Herceg Institute of Aging, Tel Aviv University, Tel Aviv, Israel Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada University of Edinburgh, Edinburgh, United Kingdom Estudios Clínicos Latino América, Rosario, Argentina Eli Lilly and Company, Indianapolis, IN, United States St John's Medical College, Bangalore, India Department of Medicine, University of Washington, Seattle, WA, United States Department of Medicine, Oregon Health and Science University PortlandOR, United States Department of Medicine K2, Karolinska Institutet, Stockholm, Sweden Medical University of South Carolina, Charleston, SC, United States Memphis Veterans Affairs Medical Center, Memphis, TN, United States Mossakowski Medical Research Centre, Polish Academy of Sciences and Central Clinical Hospital, Warsaw, Poland Semmelweis University, Hungarian Institute of Cardiology, Budapest, Hungary Universidad de La Frontera, Temuco, Chile Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, ON, Canada Masira Research Institute, Medical School, Universidad de Santander, Bucaramanga, Colombia Latvijas Universitate, Riga, Latvia National Medical Research Center of Cardiology, Moscow, Russian Federation Department of Medicine, University of Cape Town, Cape Town, South Africa Baker Heart and Diabetes Institute, Melbourne, VIC, Australia Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan Robert Koch Medical Center, Sofia, Bulgaria Cited By :53 Export Date: 9 August 2022 CODEN: LNAEA Correspondence Address: Gerstein, H.C.; McMaster University Department of MedicineCanada; email: gerstein@mcmaster.ca 0 false 2026-08-31T11:16:46.221+0000 2021-01-26T16:30:50.799+0000 2020-10-13T07:54:45.361+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2025-09-19T08:32:58.811+0000 2025-09-19T08:32:58.811+0000 2020-10-13T09:52:32.426+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Cukierman-Yaffe, Tali Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial true true /api/journal/10000877 REVIEWED true false 10000877 false 10000877 true 1474-4422 1474-4465 Journal FOREIGN 19 7 582 590 582 9 2020 Background Diabetes is an independent risk factor for cognitive impairment. We aimed to investigate the association between the glucagon-like peptide-1 (GLP-1) receptor agonist dulaglutide and cognitive impairment as an exploratory analysis within the Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND) trial. Methods REWIND is a randomised, double-blind placebo-controlled trial at 371 sites in 24 countries. We included men and women (aged >= 50 years) with either established or newly diagnosed type 2 diabetes and additional cardiovascular risk factors, glycated haemoglobin of up to 9.5% (80 mmol/mol) on a maximum of two oral glucose-lowering drugs with or without basal insulin, and a body-mass index of at least 23 kg/m(2). Participants were randomly assigned (1:1) subcutaneous injections once a week of either dulaglutide (1.5 mg) or an equal volume of matching placebo. Randomisation was done using a computer-generated code with stratification by site. Participants and all study personnel were masked to treatment allocation until the database was locked. Participants were followed up at least every 6 months for the composite primary outcome of stroke, myocardial infarction, or death from cardiovascular or unknown causes. Cognitive function was assessed at baseline and during follow-up using the Montreal Cognitive Assessment (MoCA) and Digit Symbol Substitution Test (DSST). We present here the exploratory primary cognitive outcome, which was the first occurrence of a follow-up score on MoCA or DSST that was 1.5 S Ds or more below the baseline mean score in the participant's country. All analyses were done using an intention-to-treat approach. The REWIND trial is registered with ClinicalTrials.gov, NCT01394952. Findings Between Aug 18, 2011, and Aug 14, 2013, 9901 participants were randomly assigned to either dulaglutide (n=4949) or placebo (n=4952). During median follow-up of 5.4 (IQR 5.1-5.9) years, 8828 participants provided a baseline and one or more follow-up MoCA or DSST scores, of whom 4456 were assigned dulaglutide and 4372 were assigned placebo. The cognitive outcome occurred in 4.05 per 100 patient-years in participants assigned dulaglutide and 4.35 per 100 patient-years in people assigned placebo (hazard ratio [HR] 0.93, 95% CI 0.85-1.02; p=0.11). After post-hoc adjustment for individual standardised baseline scores, the hazard of substantive cognitive impairment was reduced by 14% in those assigned dulaglutide (HR 0.86, 95% CI 0.79-0.95; p=0.0018). Interpretation Long-term treatment with dulaglutide might reduce cognitive impairment in people with type 2 diabetes. Further studies of this drug focused on brain health and cognitive function are clearly indicated. true 2020 true true true false true false NONE 2026-08-31 false 253 1 253 241 1 253 248 238 217 253 253 241 241 241 12 0 253 241 253 241 0 2 2 Folyóiratcikk Journal Article 24 251 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 6 5 6 5 2021 0 28 25 28 25 2022 0 36 33 36 33 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/api/ratingtype/10002 sjr true true ClassificationExternal 2728 /api/classificationexternal/2728 true 2728 true D1 DIRECT true true /api/publication/31627448 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Cukierman-Yaffe Tali </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gerstein Hertzel C. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Colhoun Helen M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Diaz Rafael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Perez Luis-Emilio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lakshmanan Mark </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bethel Angelyn </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Xavier Denis </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Probstfield Jeffrey </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Riddle Matthew C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ryden Lars </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Atisso Charles Messan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hall Stephanie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rao-Melacini Purnima </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Basile Jan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cushman William C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Franek Edward </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002738"><a href="/gui2/?type=authors&mode=browse&sel=10002738" target="_blank">Keltai Matyas (<span class="authorship-author-name">Keltai Mátyás</span> <span class="authorAux-mtmt"> Klinikai kardiológia</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lanas Fernando </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Leiter Lawrence A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lopez-Jaramillo Patricio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pirags Valdis </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pogosova Nana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Raubenheimer Peter J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shaw Jonathan E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sheu Wayne H-H </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Temelkova-Kurktschiev Theodora </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31627448" target="_blank">Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial</a></div> <div> <span class="journal-title">LANCET NEUROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-4422">1474-4422</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-4465">1474-4465</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">7</span> <span class="page"> pp 582-590 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/S1474-4422(20)30173-3" target="_blank" href="https://doi.org/10.1016/S1474-4422%2820%2930173-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000545358600015" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000545358600015"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85086471652" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85086471652"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="32562683" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32562683&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 253</span> | Független: 241 | Függő: 12 | Nem jelölt: 0 | WoS jelölt: 238 | Scopus jelölt:&nbsp;217 | WoS/Scopus jelölt:&nbsp;253 | DOI jelölt:&nbsp;248 (Nem nyilvános:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31627448&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31627448</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2021.01.26. 17:30 Farkas Eszter (Gottsegen admin4 - INAKTÍV) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Endocrinology Institute, Gertner Institute, Sheba Medical Center, Ramat-Gan, Israel Epidemiology Department, Sackler School of Medicine, Herceg Institute of Aging, Tel Aviv University, Tel Aviv, Israel Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada University of ...</pre> </div></div>