https://m2.mtmt.hu/ hun 2026-09-22 05:50 JournalArticle 31623716 VALIDATED true 0 false 2026-05-28T09:38:57.630+0000 2024-03-18T13:24:57.990+0000 2020-10-09T12:34:20.424+0000 true 10011564 Laczka Csilla /api/author/10011564 Author Laczka Csilla (Biokémia, molekuláris biológia) true 10011564 2025-03-04T11:57:17.632+0000 2022-07-21T09:20:40.485+0000 true 10003134 Wolf György /api/admin/10003134 Admin Wolf György (MTMT Központi admin) true 10003134 Admin 10003133 /api/admin/10003133 Boros Annamária (MTMT Központi admin) Boros Annamária true 10003133 true 2022-07-08T10:16:39.536+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Nagy, T. true true /api/journal/11507 REVIEWED CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X 1420-9071 true false 11507 false 11507 true 1420-682X 1420-9071 Journal FOREIGN 78 5 2329 2339 2329 11 2021 Atomic-level structural insight on the human ABCG2 membrane protein, a pharmacologically important transporter, has been recently revealed by several key papers. In spite of the wealth of structural data, the pathway of transmembrane movement for the large variety of structurally different ABCG2 substrates and the physiological lipid regulation of the transporter has not been elucidated. The complex molecular dynamics simulations presented here may provide a breakthrough in understanding the steps of the substrate transport process and its regulation by cholesterol. Our analysis revealed drug binding cavities other than the central binding site and delineated a putative dynamic transport pathway for substrates with variable structures. We found that membrane cholesterol accelerated drug transport by promoting the closure of cytoplasmic protein regions. Since ABCG2 is present in all major biological barriers and drug-metabolizing organs, influences the pharmacokinetics of numerous clinically applied drugs, and plays a key role in uric acid extrusion, this information may significantly promote a reliable prediction of clinically important substrate characteristics and drug-drug interactions. © 2020, The Author(s). Funding 2014031 /api/funding/2014031 (Open access funding provided by Semmelweis University) false true Funding 2014032 /api/funding/2014032 (K127961) Támogató: NKFIH false true Funding 2014033 /api/funding/2014033 (Semmelweis Science and Innovation Fund) false true true true NATIONAL 2020 true true true false true false GOLD 2026-05-28 true https://doi.org/10.1007/s00018-020-03651-3 23 0 23 19 4 23 23 23 22 23 23 19 19 19 4 0 23 19 23 19 0 11 11 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 6 4 6 4 2023 0 4 4 4 4 2024 0 5 5 5 5 2025 0 6 4 6 4 2026 0 2 2 2 2 D1 false 10015687,10078334,10027670 false false false 2021-01-05T14:11:24.185+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Enzimológiai Intézet (TTK); Transzfúziológiai Tanszék (SE / AOK / K) 7 54 3 7 0 true 10003133 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 93753229 /api/authorship/93753229 Nagy, T. [Nagy, Tamás (bioinformatika), szerző] Biofizikai és Sugárbiológiai Intézet (SE / AOK / I) 1 0.143 true false false Author 10078334 /api/author/10078334 Nagy Tamás (bioinformatika) Nagy Tamás true true Nagy T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 93753230 /api/authorship/93753230 Tóth, Á. [Tóth, Ágota (biofizika), szerző] 2 0.14285715 false false false Author 10094506 /api/author/10094506 Tóth Ágota (biofizika) Tóth Ágota true true Tóth Á. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 93753231 /api/authorship/93753231 Telbisz, Á. [Telbisz, Ágnes Mária (Biomembrán), szerző] Enzimológiai Intézet (TTK) 3 0.14285715 false false false Author 10027670 /api/author/10027670 Telbisz Ágnes Mária (Biomembrán) Telbisz Ágnes Mária true 10027670 true Telbisz Á. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 93753232 /api/authorship/93753232 Sarkadi, B. [Sarkadi, Balázs (biofizika), szerző] Enzimológiai Intézet (TTK); Biofizikai és Sugárbiológiai Intézet (SE / AOK / I) 4 0.14285715 false false false Author 1241938 /api/author/1241938 Sarkadi Balázs (biofizika) Sarkadi Balázs true 1241938 true Sarkadi B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 93753233 /api/authorship/93753233 Tordai, H. [Tordai, Hedvig (molekuláris biológia), szerző] Biofizikai és Sugárbiológiai Intézet (SE / AOK / I) 5 0.14285715 false false false Author 10010378 /api/author/10010378 Tordai Hedvig (molekuláris biológia) Tordai Hedvig true 10010378 true Tordai H. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 93753234 /api/authorship/93753234 Tordai, A. [Tordai, Attila (Orvostudomány), szerző] Transzfúziológiai Tanszék (SE / AOK / K) 6 0.14285715 false false false Author 10002439 /api/author/10002439 Tordai Attila (Orvostudomány) Tordai Attila true 10002439 true Tordai A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 93753235 /api/authorship/93753235 Hegedűs, T. ✉ [Hegedűs, Tamás (bioinformatika, b...), szerző] Biofizikai és Sugárbiológiai Intézet (SE / AOK / I) 7 0.14285715 false true true Author 10015687 /api/author/10015687 Hegedűs Tamás (bioinformatika, biofizika) Hegedűs Tamás true 10015687 true Hegedűs T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 17800919 /api/publicationidentifier/17800919 DOI: 10.1007/s00018-020-03651-3 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s00018-020-03651-3 https://doi.org/10.1007/s00018-020-03651-3 false true PublicationIdentifier 17822945 /api/publicationidentifier/17822945 WoS: 000573028400001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000573028400001 https://www.webofscience.com/wos/woscc/full-record/000573028400001 false true PublicationIdentifier 17800918 /api/publicationidentifier/17800918 Scopus: 85091466123 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85091466123 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85091466123 false true PublicationIdentifier 17834165 /api/publicationidentifier/17834165 PubMed: 32979053 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 32979053 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32979053&dopt=Abstract false true Classification 10575 /api/classification/10575 Biokémia és molekuláris biológia true true Keyword 4573 /api/keyword/4573 ABCG2 true 4573 true Keyword 1002342 /api/keyword/1002342 molecular dynamics true 1002342 true Keyword 1531768 /api/keyword/1531768 cholesterol regulation true true Keyword 1796309 /api/keyword/1796309 Multidrug transport true true SjrRating 11236242 /api/sjrrating/11236242 sjr:D1 (2021) Scopus - Cellular and Molecular Neuroscience CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X 1420-9071 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2804 /api/classificationexternal/2804 Scopus - Cellular and Molecular Neuroscience true 2804 true D1 DIRECT true true Reference 285241 /api/reference/285241 1. 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(2021) CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X 1420-9071 78 5 2329-2339<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10078334"><a href="/gui2/?type=authors&mode=browse&sel=10078334" target="_blank">Nagy T. (<span class="authorship-author-name">Nagy Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094506"><a href="/gui2/?type=authors&mode=browse&sel=10094506" target="_blank">Tóth Á. (<span class="authorship-author-name">Tóth Ágota</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027670"><a href="/gui2/?type=authors&mode=browse&sel=10027670" target="_blank">Telbisz Á. (<span class="authorship-author-name">Telbisz Ágnes Mária</span> <span class="authorAux-mtmt"> Biomembrán</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi B. (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010378"><a href="/gui2/?type=authors&mode=browse&sel=10010378" target="_blank">Tordai H. (<span class="authorship-author-name">Tordai Hedvig</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002439"><a href="/gui2/?type=authors&mode=browse&sel=10002439" target="_blank">Tordai A. (<span class="authorship-author-name">Tordai Attila</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Transzfúziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs T. ✉ (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31623716" target="_blank">The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations</a></div> <div> <span class="journal-title">CELLULAR AND MOLECULAR LIFE SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-682X">1420-682X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-9071">1420-9071</a>)</span>: <span class="journal-volume">78</span> <span class="journal-issue">5</span> <span class="page"> pp 2329-2339 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s00018-020-03651-3" target="_blank" href="https://doi.org/10.1007/s00018-020-03651-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000573028400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000573028400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85091466123" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85091466123"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32979053" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32979053&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 23</span> | Független: 19 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 23 | Scopus jelölt:&nbsp;22 | WoS/Scopus jelölt:&nbsp;23 | DOI jelölt:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31623716&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31623716</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (K127961) Támogató: NKFIH, (Semmelweis Science and Innovation Fund) </div> <div class="lastModified">Utolsó módosítás: 2024.03.18. 14:24 Tóth Ágota (biofizika) </div> <div class="lockedBy">Központi kezelésű 2022.07.08. 12:16 Boros Annamária (MTMT Központi admin) </div> </div></div>