https://m2.mtmt.hu/ eng 2026-09-22 05:02 JournalArticle 31623292 VALIDATED true Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital, Nottingham, NG5 1PB, United Kingdom Department of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom Vascular Medicine, Division of Medical Sciences and GEM, University of Nottingham, Nottingham, United Kingdom School of Medicine, University of Western Australia, Perth, Australia Stroke Medicine, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom Department of Neurology, Selcuk University Medical Faculty, Konya, Turkey Department of Neurology, Semmelweis University, Budapest, Hungary Neurology Unit, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy Department of Stroke, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom Cited By :9 Export Date: 7 October 2022 Correspondence Address: Sprigg, N.; Stroke Trials Unit, City Hospital, United Kingdom; email: nikola.sprigg@nottingham.ac.uk 0 false 2026-05-20T07:37:48.473+0000 2022-04-06T12:50:55.639+0000 2020-10-09T08:54:43.466+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2024-10-17T11:22:07.724+0000 2022-04-06T12:50:55.651+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Law, Zhe Kang Predictors and Outcomes of Neurological Deterioration in Intracerebral Hemorrhage: Results from the TICH-2 Randomized Controlled Trial true true /api/journal/10028474 REVIEWED true false 10028474 false 10028474 true 1868-4483 1868-601X Journal FOREIGN 12 2 275 283 275 9 2021 Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexamic acid in IntraCerebral Hemorrhage-2 (TICH-2) randomized controlled trial were analyzed. Neurological deterioration was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) of >= 4 or a decline in Glasgow Coma Scale of >= 2. Neurological deterioration was considered to be early if it started <= 48 h and late if commenced between 48 h and 7 days after onset. Logistic regression was used to identify predictors and effects of neurological deterioration and the effect of tranexamic acid on neurological deterioration. Of 2325 patients, 735 (31.7%) had neurological deterioration: 590 (80.3%) occurred early and 145 (19.7%) late. Predictors of early neurological deterioration included recruitment from the UK, previous ICH, higher admission systolic blood pressure, higher NIHSS, shorter onset-to-CT time, larger baseline hematoma, intraventricular hemorrhage, subarachnoid extension and antiplatelet therapy. Older age, male sex, higher NIHSS, previous ICH and larger baseline hematoma predicted late neurological deterioration. Neurological deterioration was independently associated with a modified Rankin Scale of > 3 (aOR 4.98, 3.70-6.70;p < 0.001). Tranexamic acid reduced the risk of early (aOR 0.79, 0.63-0.99;p = 0.041) but not late neurological deterioration (aOR 0.76, 0.52-1.11;p = 0.15). Larger hematoma size, intraventricular and subarachnoid extension increased the risk of neurological deterioration. Neurological deterioration increased the risk of death and dependency at day 90. Tranexamic acid reduced the risk of early neurological deterioration and warrants further investigation in ICH. 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2021-01-05T11:15:53.334+0000 Neurológiai Klinika (SE / AOK / K) 1 10 1 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 93751369 /api/authorship/93751369 1 0.09090909 true false false Law Zhe Kang true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 93751370 /api/authorship/93751370 2 0.09090909 false false false Dineen Rob true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 93751371 /api/authorship/93751371 3 0.09090909 false false false England Timothy J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 93751372 /api/authorship/93751372 4 0.09090909 false false false Cala Lesley true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 93751373 /api/authorship/93751373 5 0.09090909 false false false Mistri Amit K. true false false AuthorshipType 1 /api/authorshiptype/1 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class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Law Zhe Kang </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dineen Rob </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >England Timothy J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cala Lesley </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mistri Amit K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Appleton Jason P. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ozturk Serefnur </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000800"><a href="/gui2/?type=authors&mode=browse&sel=10000800" target="_blank">Bereczki Daniel (<span class="authorship-author-name">Bereczki Dániel</span> <span class="authorAux-mtmt"> Stroke</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Neurology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ciccone Alfonso </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bath Philip M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sprigg Nikola ✉ </span> </div> <div class="autype autype-29"> Collaborative Organization: <span class="author-affil">TICH 2 Investigators</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31623292" target="_blank">Predictors and Outcomes of Neurological Deterioration in Intracerebral Hemorrhage: Results from the TICH-2 Randomized Controlled Trial</a></div> <div> <span class="journal-title">TRANSLATIONAL STROKE RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1868-4483">1868-4483</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1868-601X">1868-601X</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">2</span> <span class="page"> pp 275-283 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s12975-020-00845-6" target="_blank" href="https://doi.org/10.1007/s12975-020-00845-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000567720900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000567720900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85090773884" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85090773884"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32902808" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32902808&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 43</span> | Independent citation: 40 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 42 | Number of citations in Scopus:&nbsp;36 | WoS/Scopus assigned:&nbsp;43 | Number of citations with DOI:&nbsp;43 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31623292&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31623292</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Study Group ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Last Modified: 2022.04.06. 14:50 Rita Tichy (SE_KK_Admin5_TR, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital, Nottingham, NG5 1PB, United Kingdom Department of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom NI...</pre> </div></div>