{ "labelLang" : "hun", "responseDate" : "2024-03-19 04:11", "content" : { "otype" : "JournalArticle", "mtid" : 3161443, "status" : "VALIDATED", "published" : true, "unhandledTickets" : 0, "oldTimestamp" : "2018-07-02T22:20:38.000+0000", "deleted" : false, "oldId" : 3161443, "lastRefresh" : "2024-03-08T13:25:41.023+0000", "lastModified" : "2022-07-25T06:18:18.986+0000", "created" : "2017-01-05T13:20:21.000+0000", "creator" : { "otype" : "Author", "mtid" : 10019630, "link" : "/api/author/10019630", "label" : "Hegedűs Balázs (Kórélettan)", "familyName" : "Hegedűs", "givenName" : "Balázs", "published" : true, "oldId" : 10019630, "snippet" : true }, "lastDuplumSearch" : "2024-01-16T12:03:06.365+0000", "validated" : "2022-07-25T06:18:19.353+0000", "validator" : { "otype" : "Admin", "mtid" : 10062250, "link" : "/api/admin/10062250", "label" : "Molnár-Taga Márta (SE 4-es admin)", "familyName" : "Molnár-Taga", "givenName" : "Márta", "published" : true, "oldId" : 10062250, "snippet" : true }, "tempLockers" : [ { "otype" : "Admin", "mtid" : 10073918, "link" : "/api/admin/10073918", "label" : "Kovács Marcell (MTMT Közp., admin)", "familyName" : "Kovács", "givenName" : "Marcell", "published" : true, "snippet" : true } ], "tempLocked" : "2023-10-04T07:54:51.165+0000", "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Torok, S", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 8662961, "link" : "/api/authorship/8662961", "label" : "Torok, S [Török, Szilvia (Onkológia), szerző] Mellkassebészeti Klinika (SE / AOK / K)", "listPosition" : 1, "share" : 0.053, "first" : true, "last" : false, "author" : { "otype" : "Author", "mtid" : 10055887, "link" : "/api/author/10055887", "label" : "Török Szilvia (Onkológia)", "familyName" : "Török", "givenName" : "Szilvia", "published" : true, "oldId" : 10055887, "snippet" : true }, "familyName" : "Torok", "givenName" : "S", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468122, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662962, "link" : "/api/authorship/8662962", "label" : "Rezeli, M [Rezeli, Melinda (mass spectrometry), szerző]", "listPosition" : 2, "share" : 0.05263158, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10024371, "link" : "/api/author/10024371", "label" : "Rezeli Melinda (mass spectrometry)", "familyName" : "Rezeli", "givenName" : "Melinda", "published" : true, "oldId" : 10024371, "snippet" : true }, "familyName" : "Rezeli", "givenName" : "M", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468121, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662963, "link" : "/api/authorship/8662963", "label" : "Kelemen, O", "listPosition" : 3, "share" : 0.05263158, "first" : false, "last" : false, "familyName" : "Kelemen", "givenName" : "O", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468120, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662964, "link" : "/api/authorship/8662964", "label" : "Vegvari, A", "listPosition" : 4, "share" : 0.05263158, "first" : false, "last" : false, "familyName" : "Vegvari", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468119, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662965, "link" : "/api/authorship/8662965", "label" : "Watanabe, K", "listPosition" : 5, "share" : 0.05263158, "first" : false, "last" : false, "familyName" : "Watanabe", "givenName" : "K", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468118, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662966, "link" : "/api/authorship/8662966", "label" : "Sugihara, Y", "listPosition" : 6, "share" : 0.05263158, "first" : false, "last" : false, "familyName" : "Sugihara", "givenName" : "Y", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468117, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662967, "link" : "/api/authorship/8662967", "label" : "Tisza, A [Sólyom-Tisza, Anna (Onkológia), szerző]", "listPosition" : 7, "share" : 0.05263158, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10072820, "link" : "/api/author/10072820", "label" : "Sólyom-Tisza Anna (Onkológia)", "familyName" : "Sólyom-Tisza", "givenName" : "Anna", "published" : true, "snippet" : true }, "familyName" : "Tisza", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468116, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662968, "link" : "/api/authorship/8662968", "label" : "Marton, T", "listPosition" : 8, "share" : 0.05263158, "first" : false, "last" : false, "familyName" : "Marton", "givenName" : "T", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468115, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662969, "link" : "/api/authorship/8662969", "label" : "Kovacs, I [Kovács, Ildikó (Tumorbiológia), szerző]", "listPosition" : 9, "share" : 0.05263158, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10058741, "link" : "/api/author/10058741", "label" : "Kovács Ildikó (Tumorbiológia)", "familyName" : "Kovács", "givenName" : "Ildikó", "published" : true, "oldId" : 10058741, "snippet" : true }, "familyName" : "Kovacs", "givenName" : "I", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468114, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662970, "link" : "/api/authorship/8662970", "label" : "Tovari, J [Tóvári, József (Daganatbiológia, ...), szerző] Országos Onkológiai Intézet", "listPosition" : 10, "share" : 0.05263158, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10009941, "link" : "/api/author/10009941", "label" : "Tóvári József (Daganatbiológia, áttétképzés)", "familyName" : "Tóvári", "givenName" : "József", "published" : true, "oldId" : 10009941, "snippet" : true }, "familyName" : "Tovari", "givenName" : "J", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468113, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662971, "link" : "/api/authorship/8662971", "label" : "Laszlo, V [Laszlo, Viktoria (tumorbiologia), szerző]", "listPosition" : 11, "share" : 0.05263158, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10037177, "link" : "/api/author/10037177", "label" : "Laszlo Viktoria (tumorbiologia)", "familyName" : "Laszlo", "givenName" : "Viktoria", "published" : true, "oldId" : 10037177, "snippet" : true }, "familyName" : "Laszlo", "givenName" : "V", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468112, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662972, "link" : "/api/authorship/8662972", "label" : "Helbich, TH", "listPosition" : 12, "share" : 0.05263158, "first" : false, "last" : false, "familyName" : "Helbich", "givenName" : "TH", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468111, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662973, "link" : "/api/authorship/8662973", "label" : "Hegedus, B [Hegedűs, Balázs (Kórélettan), szerző] MTA-SE Molekuláris Onkológia Kutatócsoport (SE / AOK / I / IISZPI)", "listPosition" : 13, "share" : 0.05263158, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10019630, "link" : "/api/author/10019630", "label" : "Hegedűs Balázs (Kórélettan)", "familyName" : "Hegedűs", "givenName" : "Balázs", "published" : true, "oldId" : 10019630, "snippet" : true }, "familyName" : "Hegedus", "givenName" : "B", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468110, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662974, "link" : "/api/authorship/8662974", "label" : "Klikovits, T [Klikovits, Thomas (Mellkassebészet), szerző]", "listPosition" : 14, "share" : 0.05263158, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10061941, "link" : "/api/author/10061941", "label" : "Klikovits Thomas (Mellkassebészet)", "familyName" : "Klikovits", "givenName" : "Thomas", "published" : true, "oldId" : 10061941, "snippet" : true }, "familyName" : "Klikovits", "givenName" : "T", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468109, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662975, "link" : "/api/authorship/8662975", "label" : "Hoda, MA", "listPosition" : 15, "share" : 0.05263158, "first" : false, "last" : false, "familyName" : "Hoda", "givenName" : "MA", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468108, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662976, "link" : "/api/authorship/8662976", "label" : "Klepetko, W", "listPosition" : 16, "share" : 0.05263158, "first" : false, "last" : false, "familyName" : "Klepetko", "givenName" : "W", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468107, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662977, "link" : "/api/authorship/8662977", "label" : "Paku, S [Paku, Sándor (Onkológia), szerző] I. Sz. Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I)", "listPosition" : 17, "share" : 0.05263158, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10000740, "link" : "/api/author/10000740", "label" : "Paku Sándor (Onkológia)", "familyName" : "Paku", "givenName" : "Sándor", "published" : true, "oldId" : 10000740, "snippet" : true }, "familyName" : "Paku", "givenName" : "S", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468106, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662978, "link" : "/api/authorship/8662978", "label" : "Marko-Varga, G** ✉", "listPosition" : 18, "share" : 0.053, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Marko-Varga", "givenName" : "G", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468105, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8662979, "link" : "/api/authorship/8662979", "label" : "Dome, B ✉ [Döme, Balázs (Tumor indukált an...), szerző] Mellkassebészeti Klinika (SE / AOK / K)", "listPosition" : 19, "share" : 0.053, "first" : false, "last" : true, "corresponding" : true, "author" : { "otype" : "Author", "mtid" : 10000046, "link" : "/api/author/10000046", "label" : "Döme Balázs (Tumor indukált angiogenezis)", "familyName" : "Döme", "givenName" : "Balázs", "published" : true, "oldId" : 10000046, "snippet" : true }, "familyName" : "Dome", "givenName" : "B", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25468104, "snippet" : true } ], "title" : "Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 1159571, "link" : "/api/publicationidentifier/1159571", "label" : "DOI: 10.7150/thno.16767", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaType" : "GOLD", "oaFree" : true, "validState" : "IDENTICAL", "idValue" : "10.7150/thno.16767", "realUrl" : "https://doi.org/10.7150/thno.16767", "published" : false, "oldId" : 1514645, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1159573, "link" : "/api/publicationidentifier/1159573", "label" : "REAL: 61360", "source" : { "otype" : "SwordSource", "mtid" : 36, "link" : "/api/publicationsource/36", "label" : "REAL", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "REAL", "nameEng" : "REAL", "linkPattern" : "http://real.mtak.hu/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 36, "snippet" : true }, "oaType" : "GREEN", "oaFree" : false, "validState" : "NO", "idValue" : "61360", "realUrl" : "http://real.mtak.hu/61360", "published" : false, "oldId" : 1630290, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1159574, "link" : "/api/publicationidentifier/1159574", "label" : "SE Repozitórium: 3998", "source" : { "otype" : "SwordSource", "mtid" : 84, "link" : "/api/publicationsource/84", "label" : "SE Repozitórium", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "SE Repozitórium", "nameEng" : "SE Repozitórium", "linkPattern" : "https://repo.lib.semmelweis.hu/handle/123456789/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 84, "snippet" : true }, "oaType" : "GREEN", "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "3998", "realUrl" : "https://repo.lib.semmelweis.hu/handle/123456789/3998", "published" : false, "oldId" : 1514676, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1159569, "link" : "/api/publicationidentifier/1159569", "label" : "WoS: 000396555900013", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "000396555900013", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000396555900013", "published" : false, "oldId" : 1673634, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1159570, "link" : "/api/publicationidentifier/1159570", "label" : "Scopus: 85008425346", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "85008425346", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85008425346", "published" : false, "oldId" : 1544477, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1159572, "link" : "/api/publicationidentifier/1159572", "label" : "PubMed: 28042343", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "28042343", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28042343&dopt=Abstract", "published" : false, "oldId" : 1514646, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1159575, "link" : "/api/publicationidentifier/1159575", "label" : "Pubmed Central: PMC5197073", "source" : { "otype" : "PlainSource", "mtid" : 137, "link" : "/api/publicationsource/137", "label" : "Pubmed Central", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "Pubmed Central", "linkPattern" : "http://www.ncbi.nlm.nih.gov/pmc/articles/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 137, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "PMC5197073", "realUrl" : "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197073", "published" : false, "oldId" : 1630351, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10023055, "link" : "/api/journal/10023055", "label" : "THERANOSTICS 1838-7640 1838-7640", "pIssn" : "1838-7640", "eIssn" : "1838-7640", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10023055, "snippet" : true }, "volume" : "7", "issue" : "2", "firstPage" : "400", "lastPage" : "412", "firstPageOrInternalIdForSort" : "400", "pageLength" : 13, "publishedYear" : 2017, "abstractText" : "Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data obtained by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). In the first mouse model, only sunitinib exhibited broad-spectrum antivascular and antitumor activities by simultaneously suppressing vascular endothelial growth factor receptor-2 (VEGFR2) and desmin expression, and by increasing intratumoral hypoxia and inhibiting both tumor growth and vascularisation significantly. Importantly, the highest and most homogeneous intratumoral drug concentrations have been found in sunitinib-treated animals. In another animal model, where - in contrast to the first model - vatalanib was detectable at homogeneously high intratumoral concentrations, the drug significantly reduced tumor growth and angiogenesis. In conclusion, the tumor tissue penetration and thus the antiangiogenic and antitumor potential of antiangiogenic RTKIs vary among the tumor models and our study demonstrates the potential of MALDI-MSI to predict the efficacy of unlabelled small molecule antiangiogenic drugs in malignant tissue. Our approach is thus a major technical and preclinical advance demonstrating that primary resistance to angiogenesis inhibitors involves limited tumor tissue drug penetration. We also conclude that MALDI-MSI may significantly contribute to the improvement of antivascular cancer therapies.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12548, "link" : "/api/classification/12548", "label" : "Egyéb orvostudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "digital" : true, "printed" : null, "sourceYear" : 2017, "packet" : "435602", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-03-08", "oaFree" : true, "oaLink" : "https://doi.org/10.7150/thno.16767", "citationCount" : 55, "citationCountUnpublished" : 0, "citationCountWoOther" : 55, "independentCitCountWoOther" : 50, "nationalOriginCitationCount" : 6, "foreignEditionCitationCount" : 54, "doiCitationCount" : 55, "wosCitationCount" : 54, "scopusCitationCount" : 55, "wosScopusCitationCount" : 55, "wosScopusCitationCountWoOther" : 55, "wosScopusIndependentCitationCount" : 50, "wosScopusIndependentCitationCountWoOther" : 50, "independentCitationCount" : 50, "selfCitationCount" : 5, "unhandledCitationCount" : 0, "citingPubCount" : 55, "independentCitingPubCount" : 50, "citingPubCountWoOther" : 55, "independentCitingPubCountWoOther" : 50, "unhandledCitingPubCount" : 0, "citedPubCount" : 11, "citedCount" : 11, "pubStats" : { "types" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "count" : 52 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "count" : 3 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "count" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "count" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "count" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "count" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "count" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "count" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "count" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "count" : 0 } ], "citationTypes" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 } ], "years" : [ { "year" : 2017, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 3, "citingPubCount" : 3, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2018, "publicationCount" : 0, "citationCount" : 11, "independentCitationCount" : 10, "citingPubCount" : 11, "independentCitingPubCount" : 10, "oaStats" : null, "oaStats2" : null }, { "year" : 2019, "publicationCount" : 0, "citationCount" : 12, "independentCitationCount" : 9, "citingPubCount" : 12, "independentCitingPubCount" : 9, "oaStats" : null, "oaStats2" : null }, { "year" : 2020, "publicationCount" : 0, "citationCount" : 8, "independentCitationCount" : 8, "citingPubCount" : 8, "independentCitingPubCount" : 8, "oaStats" : null, "oaStats2" : null }, { "year" : 2021, "publicationCount" : 0, "citationCount" : 12, "independentCitationCount" : 12, "citingPubCount" : 12, "independentCitingPubCount" : 12, "oaStats" : null, "oaStats2" : null }, { "year" : 2022, "publicationCount" : 0, "citationCount" : 5, "independentCitationCount" : 5, "citingPubCount" : 5, "independentCitingPubCount" : 5, "oaStats" : null, "oaStats2" : null }, { "year" : 2023, "publicationCount" : 0, "citationCount" : 4, "independentCitationCount" : 3, "citingPubCount" : 4, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null } ] }, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10971961, "link" : "/api/sjrrating/10971961", "label" : "sjr:D1 (2017) Scopus - Medicine (miscellaneous) THERANOSTICS 1838-7640", "listPos" : 111, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2701, "link" : "/api/classificationexternal/2701", "label" : "Scopus - Medicine (miscellaneous)", "published" : true, "oldId" : 2701, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "hasCitationDuplums" : false, "inSelectedPubs" : "10055887,10000046,10037177,10024371", "userChangeableUntil" : "2018-02-15T08:24:23.000+0000", "publishDate" : "2017-01-05T13:22:03.000+0000", "directInstitutesForSort" : "I. Sz. Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); MTA-SE Molekuláris Onkológia Kutatócsoport (SE / AOK / I / IISZPI); Mellkassebészeti Klinika (SE / AOK / K); Országos Onkológiai Intézet", "ownerAuthorCount" : 10, "ownerInstituteCount" : 33, "directInstituteCount" : 4, "authorCount" : 19, "contributorCount" : 0, "hasQualityFactor" : true, "tempLockerIds" : [ 10073918 ], "link" : "/api/publication/3161443", "label" : "Torok S et al. Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors. (2017) THERANOSTICS 1838-7640 1838-7640 7 2 400-412", "template" : "