https://m2.mtmt.hu/ hun 2026-05-25 13:49 JournalArticle 31607225 VALIDATED true Department of Physiology, Semmelweis University, Budapest, Hungary Research Laboratory of the 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary Department of Genetics and Immunobiology, Semmelweis University, Budapest, Hungary Institute of Experimental Medicine, Eötvös Loránd Research Network (ELRN), Budapest, Hungary Department of Medicine, University of Louisville, Louisville, KY, United States Cited By :41 Export Date: 23 August 2024 CODEN: JLBIE Correspondence Address: Ligeti, E.; Department of Physiology, Hungary; email: ligeti.erzsebet@med.semmelweis-univ.hu 0 false 2026-05-20T06:41:56.487+0000 2026-04-27T08:56:19.569+0000 2020-09-22T12:10:54.756+0000 true 10000059 Kolev Kraszimir Nikolaev /api/author/10000059 Author true 10000059 2026-04-27T08:56:19.162+0000 2024-04-09T07:26:26.191+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kolonics, Ferenc Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions true true /api/journal/2054624 REVIEWED true false 2054624 false 2054624 true 0741-5400 1938-3673 Journal FOREIGN 109 4 793 806 793 14 2021 Extracellular vesicles (EVs) are important elements of intercellular communication. A plethora of different, occasionally even opposite, physiologic and pathologic effects have been attributed to these vesicles in the last decade. A direct comparison of individual observations is however hampered by the significant differences in the way of elicitation, collection, handling, and storage of the investigated vesicles. In the current work, we carried out a careful comparative study on 3, previously characterized types of EVs produced by neutrophilic granulocytes. We investigated in parallel the modulation of multiple blood-related cells and functions by medium-sized vesicles. We show that EVs released from resting neutrophils exert anti-inflammatory action by reducing production of reactive oxygen species (ROS) and cytokine release from neutrophils. In contrast, vesicles generated upon encounter of neutrophils with opsonized particles rather promote proinflammatory processes as they increase production of ROS and cytokine secretion from neutrophils and activate endothelial cells. EVs released from apoptosing cells were mainly active in promoting coagulation. We thus propose that EVs are "custom made," acquiring selective capacities depending on environmental factors prevailing at the time of their biogenesis. 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/api/sjrrating/11197308 58 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1307 /api/classificationexternal/1307 true 1307 true Q1 DIRECT true true /api/publication/31607225 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10050559"><a href="/gui2/?type=authors&mode=browse&sel=10050559" target="_blank">Kolonics Ferenc (<span class="authorship-author-name">Kolonics Ferenc</span> <span class="authorAux-mtmt"> Transzlációs immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040542"><a href="/gui2/?type=authors&mode=browse&sel=10040542" target="_blank">Kajdácsi Erika (<span class="authorship-author-name">Kajdácsi Erika</span> <span class="authorAux-mtmt"> immunológia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051354"><a href="/gui2/?type=authors&mode=browse&sel=10051354" target="_blank">Farkas Veronika J (<span class="authorship-author-name">Farkas Veronika Judit</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biokémiai és Molekuláris Biológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10031347"><a href="/gui2/?type=authors&mode=browse&sel=10031347" target="_blank">Veres Dániel S (<span class="authorship-author-name">Veres Dániel</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071730"><a href="/gui2/?type=authors&mode=browse&sel=10071730" target="_blank">Khamari Delaram (<span class="authorship-author-name">Khamari Delaram</span> <span class="authorAux-mtmt"> Extracellular vesicles</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009113"><a href="/gui2/?type=authors&mode=browse&sel=10009113" target="_blank">Kittel Ágnes (<span class="authorship-author-name">Kittel Ágnes</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil">Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Merchant Michael L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >McLeish Kenneth R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023795"><a href="/gui2/?type=authors&mode=browse&sel=10023795" target="_blank">Lőrincz Ákos M<sup>**</sup> (<span class="authorship-author-name">Lőrincz Márton Ákos</span> <span class="authorAux-mtmt"> molekuláris élettan, immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="426140"><a href="/gui2/?type=authors&mode=browse&sel=426140" target="_blank">Ligeti Erzsébet ✉ (<span class="authorship-author-name">Ligeti Erzsébet</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31607225" target="_blank">Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions</a></div> <div> <span class="journal-title">JOURNAL OF LEUKOCYTE BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0741-5400">0741-5400</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1938-3673">1938-3673</a>)</span>: <span class="journal-volume">109</span> <span class="journal-issue">4</span> <span class="page"> pp 793-806 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1002/JLB.3A0320-210R" target="_blank" href="https://doi.org/10.1002/JLB.3A0320-210R"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000570319600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000570319600001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="130917" target="_blank" href="http://real.mtak.hu/130917"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85091046488" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85091046488"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32946637" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32946637&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://academic.oup.com/jleukbio/article/109/4/793/7032809" target="_blank" href="https://academic.oup.com/jleukbio/article/109/4/793/7032809"> Egyéb URL </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85091046488?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85091046488?origin=resultslist"> Egyéb URL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="3049997199831658840" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=3049997199831658840"> Google scholar </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 75</span> | Független: 67 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 57 | Scopus jelölt:&nbsp;60 | WoS/Scopus jelölt:&nbsp;62 | DOI jelölt:&nbsp;64 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31607225&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31607225</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (119236) Támogató: NKFIH, (VEKOP-2.3.2.-16), (Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University), (Bolyai János Kutatási Ösztöndíj) Támogató: MTA </div> <div class="lastModified">Utolsó módosítás: 2026.04.27. 10:56 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Physiology, Semmelweis University, Budapest, Hungary Research Laboratory of the 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Budap...</pre> </div></div>