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Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture
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Thyroid hormones (THs) and oestrogens are crucial in the regulation of cerebellar development. TH receptors (TRs) mediate these hormone effects and are regulated by both hormone families. We reported earlier that THs and oestradiol (E2) determine TR levels in cerebellar cell culture. Here we demonstrate the effects of low concentrations (10-10 M) of the endocrine disruptor (ED) bisphenol A (BPA) on the hormonal (THs, E2) regulation of TRα,β in rat cerebellar cell culture. Primary cerebellar cell cultures, glia-containing and glia-destroyed, were treated with BPA or a combination of BPA and E2 and/or THs. Oestrogen receptor and TH receptor mRNA and protein levels were determined by real-time qPCR and Western blot techniques. The results show that BPA alone decreases, while BPA in combination with THs and/or E2 increases TR mRNA expression. In contrast, BPA alone increased receptor protein expressions, but did not further increase them in combination with THs and/or E2. The modulatory effects of BPA were mediated by the glia; however, the degree of changes also depended on the specific hormone ligand used. The results signify the importance of the regulatory mechanisms interposed between transcription and translation and raise the possibility that BPA could act to influence nuclear hormone receptor levels independently of ligand-receptor interaction.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10023277"> <a href="/gui2/?type=authors&mode=browse&sel=10023277" target="_blank">Somogyi, Virág</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10059197"> <a href="/gui2/?type=authors&mode=browse&sel=10059197" target="_blank">Horváth, Tamás L.</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10032427"> <a href="/gui2/?type=authors&mode=browse&sel=10032427" target="_blank">Tóth, István</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10002369"> <a href="/gui2/?type=authors&mode=browse&sel=10002369" target="_blank">Bartha, Tibor</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10008189"> <a href="/gui2/?type=authors&mode=browse&sel=10008189" target="_blank">Frenyó, László Vilmos</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10023247"> <a href="/gui2/?type=authors&mode=browse&sel=10023247" target="_blank">Kiss, Dávid Sándor</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10039543"> <a href="/gui2/?type=authors&mode=browse&sel=10039543" target="_blank">Jócsák, Gergely</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000056"> <a href="/gui2/?type=authors&mode=browse&sel=10000056" target="_blank">Kerti, Annamária</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Naftolin, Frederick </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10022901"> <a href="/gui2/?type=authors&mode=browse&sel=10022901" target="_blank">Zsarnovszky, Attila</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;3159049" mtid="3159049" target="_blank">Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture</a></div> <div class="pub-info"> <span class="journal-title">ACTA VETERINARIA HUNGARICA</span> <span class="journal-volume">64</span> : <span class="journal-issue">4</span> <span class="page"> pp. 497-513. , 17 p. </span> <span class="year">(2016)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:black" title="10.1556/004.2016.046" target="_blank" href="https://doi.org/10.1556/004.2016.046"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000392632700008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000392632700008"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="49695" target="_blank" href="http://real.mtak.hu/49695"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85007109177" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85007109177"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="27993100" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27993100&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:3159049 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 10 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt: 5 | WoS/Scopus jelölt: 11 | DOI jelölt: 10 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10023277"><a href="/gui2/?type=authors&mode=browse&sel=10023277" target="_blank">Somogyi Virág (<span class="authorship-author-name">Somogyi Virág</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Állatorvostudományi Egyetem">ÁTE</span>/Élettani és biokémiai tanszék</span> ; <span class="author-name" mtid="10059197"><a href="/gui2/?type=authors&mode=browse&sel=10059197" target="_blank">Horváth Tamás L. (<span class="authorship-author-name">Horváth Tamás</span> <span class="authorAux-mtmt"> Állatorvosi alaptudományok, Idegtudomány</span>) </a> </span> ; <span class="author-name" mtid="10032427"><a href="/gui2/?type=authors&mode=browse&sel=10032427" target="_blank">Tóth István (<span class="authorship-author-name">Tóth István</span> <span class="authorAux-mtmt"> Állatorvos-élettan</span>) </a> </span> <span class="author-affil"><span title="Állatorvostudományi Egyetem">ÁTE</span>/Élettani és biokémiai tanszék</span> ; <span class="author-name" mtid="10002369"><a href="/gui2/?type=authors&mode=browse&sel=10002369" target="_blank">Bartha Tibor (<span class="authorship-author-name">Bartha Tibor</span> <span class="authorAux-mtmt"> Állatorvosi élettan</span>) </a> </span> <span class="author-affil"><span title="Állatorvostudományi Egyetem">ÁTE</span>/Élettani és biokémiai tanszék</span> ; <span class="author-name" mtid="10008189"><a href="/gui2/?type=authors&mode=browse&sel=10008189" target="_blank">Frenyó László Vilmos (<span class="authorship-author-name">Frenyó V. László</span> <span class="authorAux-mtmt"> Állatorvosi élettan</span>) </a> </span> <span class="author-affil"><span title="Állatorvostudományi Egyetem">ÁTE</span>/Élettani és biokémiai tanszék</span> ; <span class="author-name" mtid="10023247"><a href="/gui2/?type=authors&mode=browse&sel=10023247" target="_blank">Kiss Dávid Sándor (<span class="authorship-author-name">Kiss Dávid Sándor</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Állatorvostudományi Egyetem">ÁTE</span>/Élettani és biokémiai tanszék</span> ; <span class="author-name" mtid="10039543"><a href="/gui2/?type=authors&mode=browse&sel=10039543" target="_blank">Jócsák Gergely (<span class="authorship-author-name">Jócsák Gergely</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Állatorvostudományi Egyetem">ÁTE</span>/Élettani és biokémiai tanszék</span> ; <span class="author-name" mtid="10000056"><a href="/gui2/?type=authors&mode=browse&sel=10000056" target="_blank">Kerti Annamária (<span class="authorship-author-name">Kerti Annamária</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Szent István Egyetem">SZIE</span>/<span title="Mezõgazdaság- és Környezettudományi Kar">MKK</span>/Állattudományi Alapok Intézet</span> ; <span class="author-name" >Naftolin Frederick </span> ; <span class="author-name" mtid="10022901"><a href="/gui2/?type=authors&mode=browse&sel=10022901" target="_blank">Zsarnovszky Attila (<span class="authorship-author-name">Zsarnovszky Attila</span> <span class="authorAux-mtmt"> Állatorvos tudomány</span>) </a> </span> <span class="author-affil"><span title="Szent István Egyetem">SZIE</span>/<span title="Mezõgazdaság- és Környezettudományi Kar">MKK</span>/Állattudományi Alapok Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;3159049" target="_blank">Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture</a></div> <div> <span class="journal-title">ACTA VETERINARIA HUNGARICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0236-6290">0236-6290</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1588-2705">1588-2705</a>)</span>: <span class="journal-volume">64</span> <span class="journal-issue">4</span> <span class="page"> pp 497-513 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:black" title="10.1556/004.2016.046" target="_blank" href="https://doi.org/10.1556/004.2016.046"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000392632700008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000392632700008"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="49695" target="_blank" href="http://real.mtak.hu/49695"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85007109177" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85007109177"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="27993100" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27993100&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 10 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt: 5 | WoS/Scopus jelölt: 11 | DOI jelölt: 10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3159049&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3159049</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3159049</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2021.09.24. 10:34 Kovács Marcell (MTMT Közp., admin) </div> <div class="lockedBy">Ideiglenesen zárolva 2021.09.15. 10:56 Kovács Marcell (MTMT Közp., admin) </div> </div></div>