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First, image segmentation is implemented on the basis of maximum between-class variance and region growing method. Second, the edge of the image concerned is filled based on calculations of mathematical morphology, followed by edge extraction, which realizes extraction of the image in the region of interest. Finally, processing and judgment concerning four indicators to determine knee osteoarthritis, namely, joint space asymmetry, articular sclerosis, rugged articular surface, and intra-articular loose bodies, were judged and judged. 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