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"2538", "lastPage" : "2547", "firstPageOrInternalIdForSort" : "2538", "pageLength" : 10, "publishedYear" : 2019, "abstractText" : "Background Fibromyalgia (FM) is a disorder characterized by widespread chronic pain as core symptom and a broad range of comorbidities. Despite the prevalence of gastrointestinal (GI) comorbidities in patients with FM, GI functions have rarely been investigated in animal models of FM. Aims The purpose of the present study is to investigate the coexistence of alterations of GI function in the reserpine-induced myalgia (RIM) rat, a validated FM model associated with disruption of monoamine system. Methods Paw withdrawal threshold (von Frey hair test) was assessed as pain-associated indicator. Gastric emptying (C-13 breath test), small intestinal transit (charcoal meal test), and fecal water content were investigated as GI functions. Results The specific regimen of reserpine for the RIM rat, i.e., 1 mg/kg s.c., once daily for three consecutive days, caused a reduction of paw withdrawal threshold (i.e., mechanical allodynia) on days 3, 5, and 7 after the first injection. The (CO2)-C-13 excreted from the RIM rat was significantly increased on day 7. The RIM rat exhibited an acceleration of small intestinal transit on day 5. Fecal water content collected from the RIM rat was significantly increased on days 3 and 5. The amount of noradrenaline was significantly decreased in GI tissues on days 3, 5, and 7 in the RIM rat. 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