Estrogen Receptor alpha (ER alpha)-targeting Compounds and Derivatives: Recent Advances in Structural Modification and Bioactivity

Guo, Wei-Yun; Zeng, Shang-Ming-Zhu; Deora, Girdhar Singh ✉; Li, Qing-Shan ✉; Ruan, Ban-Feng ✉

Angol nyelvű Tudományos Összefoglaló cikk (Folyóiratcikk)
Megjelent: CURRENT TOPICS IN MEDICINAL CHEMISTRY 1568-0266 1873-4294 19 (15) pp. 1318-1337 2019
  • SJR Scopus - Drug Discovery: Q2
    Breast cancer is the most common cancer suffered by female, and the second highest cause of cancer-related death among women worldwide. At present, hormone therapy is still the main treatment route and can be divided into three main categories: selective estrogen receptor modulators (SERMs), selective estrogen receptor downregulators (SERDs), and aromatase inhibitors (AIs). However, breast cancer is difficult to cure even after several rounds of anti-estrogen therapy and most drugs have serious side-effects. Here, we review the literature published over the past five years regarding the isolation and synthesis of analogs and their derivatives.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-05-14 14:54