Breast cancer is the most common cancer suffered by female, and the second highest
cause of cancer-related death among women worldwide. At present, hormone therapy is
still the main treatment route and can be divided into three main categories: selective
estrogen receptor modulators (SERMs), selective estrogen receptor downregulators (SERDs),
and aromatase inhibitors (AIs). However, breast cancer is difficult to cure even after
several rounds of anti-estrogen therapy and most drugs have serious side-effects.
Here, we review the literature published over the past five years regarding the isolation
and synthesis of analogs and their derivatives.