{ "labelLang" : "eng", "responseDate" : "2024-03-28 22:12", "content" : { "otype" : "JournalArticle", "mtid" : 31553379, "status" : "APPROVED", "published" : true, "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2024-02-27T14:10:22.627+0000", "lastModified" : "2024-02-27T13:28:55.313+0000", "created" : "2020-09-02T16:46:44.732+0000", "creator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "import WoS (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "lastDuplumOK" : "2024-02-27T11:14:33.134+0000", "lastDuplumSearch" : "2024-02-27T11:14:33.134+0000", "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Journal Article", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Article (Journal Article)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Journal Article", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Scientific", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "English", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Khammari, Anahita", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 93310668, "link" : "/api/authorship/93310668", "label" : "Khammari, Anahita", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Khammari", "givenName" : "Anahita", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 93310669, "link" : "/api/authorship/93310669", "label" : "Arab, Seyed Shahriar ✉", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Arab", "givenName" : "Seyed Shahriar", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 93310670, "link" : "/api/authorship/93310670", "label" : "Ejtehadi, Mohammad Reza ✉", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Ejtehadi", "givenName" : "Mohammad Reza", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "The hot sites of alpha-synuclein in amyloid fibril formation", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 17611470, "link" : "/api/publicationidentifier/17611470", "label" : "DOI: 10.1038/s41598-020-68887-2", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.1038/s41598-020-68887-2", "realUrl" : "https://doi.org/10.1038/s41598-020-68887-2", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 17611469, "link" : "/api/publicationidentifier/17611469", "label" : "WoS: 000556401400002", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000556401400002", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000556401400002", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 17611471, "link" : "/api/publicationidentifier/17611471", "label" : "Scopus: 85088386488", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85088386488", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85088386488", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 17611472, "link" : "/api/publicationidentifier/17611472", "label" : "PubMed: 32699326", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "32699326", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32699326&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10019966, "link" : "/api/journal/10019966", "label" : "SCIENTIFIC REPORTS 2045-2322 2045-2322", "pIssn" : "2045-2322", "eIssn" : "2045-2322", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10019966, "snippet" : true }, "volume" : "10", "issue" : "1", "internalId" : "12175", "firstPageOrInternalIdForSort" : "12175", "pageLength" : 14, "publishedYear" : 2020, "abstractText" : "The role of alpha-synuclein (alpha S) amyloid fibrillation has been recognized in various neurological diseases including Parkinson's Disease (PD). In early stages, fibrillation occurs by the structural transition from helix to extended states in monomeric alpha S followed by the formation of beta-sheets. This alpha-helix to beta-sheet transition (alpha beta T) speeds up the formation of amyloid fibrils through the formation of unstable and temporary configurations of the alpha S. In this study, the most important regions that act as initiating nuclei and make unstable the initial configuration were identified based on sequence and structural information. In this regard, a Targeted Molecular Dynamics (TMD) simulation was employed using explicit solvent models under physiological conditions. Identified regions are those that are in the early steps of structural opening. The trajectory was clustered the structures characterized the intermediate states. The findings of this study would help us to better understanding of the mechanism of amyloid fibril formation.", "subjects" : [ { "otype" : "Classification", "mtid" : 10799, "link" : "/api/classification/10799", "label" : "Other natural sciences", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2020, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : false, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-02-27", "oaFree" : false, "oaLink" : "http://www.nature.com/srep/index.html", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "MtaRating", "mtid" : 519359, "link" : "/api/mtarating/519359", "label" : "IX. Szociológiai Tudományos Bizottság:A nemzetközi SCIENTIFIC REPORTS 2045-2322 2045-2322", "ratingType" : { "otype" : "RatingType", "mtid" : 10007, "link" : "/api/ratingtype/10007", "label" : "IX. Szociológiai Tudományos Bizottság", "code" : "SZTB", "institute" : { "otype" : "Institute", "mtid" : 14102, "link" : "/api/institute/14102", "label" : "Szociológiai Tudományos Bizottság HASSELIX SZTB [1901-]", "childrenCount" : 0, "allowInstForum" : false, "allowOnlineRegistration" : true, "name" : "Szociológiai Tudományos Bizottság", "nameEng" : "Szociológiai Tudományos Bizottság", "published" : true, "oldId" : 14102, "snippet" : true }, "published" : true, "snippet" : true }, "val" : "A nemzetközi", "published" : true, "oldId" : 19359, "snippet" : true }, { "otype" : "MtaRating", "mtid" : 11551161, "link" : "/api/mtarating/11551161", "label" : "IX. Regionális Tudományok Bizottsága:B nemzetközi SCIENTIFIC REPORTS 2045-2322 2045-2322", "ratingType" : { "otype" : "RatingType", "mtid" : 10010, "link" : "/api/ratingtype/10010", "label" : "IX. Regionális Tudományok Bizottsága", "code" : "RegTB", "institute" : { "otype" : "Institute", "mtid" : 14100, "link" : "/api/institute/14100", "label" : "Regionális Tudományok Bizottsága HASSELIX RTB [1901-]", "childrenCount" : 0, "allowInstForum" : false, "allowOnlineRegistration" : true, "name" : "Regionális Tudományok Bizottsága", "nameEng" : "Regionális Tudományok Bizottsága", "published" : true, "oldId" : 14100, "snippet" : true }, "published" : true, "snippet" : true }, "val" : "B nemzetközi", "published" : false, "snippet" : true }, { "otype" : "SjrRating", "mtid" : 10859083, "link" : "/api/sjrrating/10859083", "label" : "sjr:D1 (2020) Scopus - Multidisciplinary SCIENTIFIC REPORTS 2045-2322", "listPos" : 10, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1000, "link" : "/api/classificationexternal/1000", "label" : "Scopus - Multidisciplinary", "published" : true, "oldId" : 1000, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "mtaRatingsForSort" : "A nemzetközi", "hasCitationDuplums" : false, "userChangeableUntil" : "2024-05-27T11:29:25.122+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 6, "ownerInstituteCount" : 18, "directInstituteCount" : 0, "authorCount" : 3, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/31553379", "label" : "Khammari Anahita et al. The hot sites of alpha-synuclein in amyloid fibril formation. (2020) SCIENTIFIC REPORTS 2045-2322 2045-2322 10 1", "template" : "