https://m2.mtmt.hu/ eng 2026-10-24 08:00 JournalArticle 3150355 ADMIN_APPROVED true Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest, 1083, Hungary János Szentágothai School of Neurosciences, Semmelweis University, Budapest, 1085, Hungary Department of Neuroscience, Physiology, and Pharmacology, University College London, London, WC1E 6BT, United Kingdom Institute of Basic Medical Sciences, University of Oslo, Oslo, 0317, Norway Cited By :37 Export Date: 18 October 2022 CODEN: NERNE Correspondence Address: Silver, R.A.; Department of Neuroscience, United Kingdom; email: a.silver@ucl.ac.uk Chemicals/CAS: connexin 36; Connexins Funding details: Wellcome Trust, WT, 095667 Funding details: Seventh Framework Programme, FP7, 249667 Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA, LP2012-29 Funding text 1: Z.N. is the recipient of a Hungarian Academy of Sciences Momentum Grant (Lendület, LP2012-29) and an ERC Advanced Grant. A.L. was supported by a Janos Bolyai Scholarship. R.A.S. is in receipt of a Wellcome Trust Principal Research Fellowship (095667) and ERC Advanced Grant (249667). F.L. was supported by a postdoctoral Fondation Fyssen fellowship and a Marie Curie fellowship (FP7 program). We thank Dóra Rónaszéki and Éva Dobai for their excellent technical help and A. Valera for critically reading the manuscript. 0 2018-07-02T22:20:14.000+0000 false 3150355 2026-10-17T23:17:40.737+0000 2021-07-01T09:38:39.795+0000 2016-12-09T08:35:30.000+0000 true 10000499 Nusser Zoltán /api/author/10000499 Author true 10000499 2025-03-17T08:33:12.814+0000 2025-03-17T08:33:12.814+0000 2021-07-01T09:38:39.807+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szoboszlay, M Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells. true true /api/journal/3357 REVIEWED true false 3357 false 3357 true 0896-6273 1097-4199 Journal FOREIGN 90 5 1043 1056 1043 14 2016 The strength and variability of electrical synaptic connections between GABAergic interneurons are key determinants of spike synchrony within neuronal networks. However, little is known about how electrical coupling strength is determined due to the inaccessibility of gap junctions on the dendritic tree. We investigated the properties of gap junctions in cerebellar interneurons by combining paired somato-somatic and somato-dendritic recordings, anatomical reconstructions, immunohistochemistry, electron microscopy, and modeling. By fitting detailed compartmental models of Golgi cells to their somato-dendritic voltage responses, we determined their passive electrical properties and the mean gap junction conductance (0.9 nS). Connexin36 immunofluorescence and freeze-fracture replica immunogold labeling revealed a large variability in gap junction size and that only 18% of the 340 channels are open in each plaque. Our results establish that the number of gap junctions per connection is the main determinant of both the strength and variability in electrical coupling between Golgi cells. 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<span title="Semmelweis University">SU</span>/School of Ph. 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Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012931"><a href="/gui2/?type=authors&mode=browse&sel=10012931" target="_blank">Lorincz A<sup>*</sup> (<span class="authorship-author-name">Lőrincz Andrea</span> <span class="authorAux-mtmt"> Neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lanore F<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vervaeke K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Silver RA ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z ✉ (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3150355" target="_blank">Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells.</a></div> <div> <span class="journal-title">NEURON</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0896-6273">0896-6273</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-4199">1097-4199</a>)</span>: <span class="journal-volume">90</span> <span class="journal-issue">5</span> <span class="page"> pp 1043-1056 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.neuron.2016.03.029" target="_blank" href="https://doi.org/10.1016/j.neuron.2016.03.029"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="48769" target="_blank" href="https://real.mtak.hu/48769"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000378523900016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000378523900016"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84964587181" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84964587181"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="27133465" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27133465&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 53</span> | Independent citation: 50 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 51 | Number of citations in Scopus:&nbsp;50 | WoS/Scopus assigned:&nbsp;53 | Number of citations with DOI:&nbsp;53 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3150355&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3150355</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> <span class="oldId">Old id: 3150355</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Wellcome Trust(249667), Wellcome Trust(095667) </div> <div class="lastModified">Last Modified: 2021.07.01. 11:38 Márta Molnár-Taga (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest, 1083, Hungary János Szentágothai School of Neurosciences, Semmelweis University, Budapest, 1085, Hungary Department of Neuroscience, Physiology, and Pharmacology, University College London, London, WC1E 6BT, United Kingdom ...</pre> </div></div>