https://m2.mtmt.hu/ eng 2026-10-25 09:50 JournalArticle 3150354 APPROVED true Cited By :11 Export Date: 18 October 2022 Correspondence Address: Eyre, M.D.; Laboratory of Cellular Neurophysiology, Hungary Chemicals/CAS: tetrodotoxin, 4368-28-9, 4664-41-9; 4 aminobutyric acid, 28805-76-7, 56-12-2; gamma-Aminobutyric Acid; Receptors, GABA-A Funding details: Seventh Framework Programme, FP7, 293681 0 2018-02-20T06:42:12.000+0000 false 3150354 2026-10-17T23:17:22.035+0000 2021-04-28T10:03:40.233+0000 2016-12-09T08:35:29.000+0000 true 10000499 Nusser Zoltán /api/author/10000499 Author true 10000499 2025-04-10T10:09:32.502+0000 2025-04-10T10:09:32.502+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Eyre, MD Only a Minority of the Inhibitory Inputs to Cerebellar Golgi Cells Originates from Local GABAergic Cells. true true /api/journal/10047435 REVIEWED true false 10047435 false 10047435 true 2373-2822 Journal FOREIGN 3 3 317 334 317 14 2016 Cerebellar Golgi cells (GoCs) efficiently control the spiking activity of granule cells through GABAA receptor-mediated tonic and phasic inhibition. Recent experiments provided compelling evidence for the extensive interconnection of GoCs through electrical synapses, but their chemical inhibitory synaptic inputs are debated. Here, we investigated the GABAergic synaptic inputs of GoCs using in vitro electrophysiology and quantitative light microscopy (LM) and electron microscopy (EM). We characterized GABAA receptor-mediated IPSCs in GoCs and Lugaro cells (LuCs), and found that IPSCs in GoCs have lower frequencies, smaller amplitudes, and much slower decay kinetics. Pharmacological and LM immunolocalization experiments revealed that GoCs express alpha3, whereas LuCs express alpha1 subunit-containing GABAA receptors. The selective expression and clustered distribution of the alpha3 subunit in GoCs allowed the quantitative analysis of GABAergic synapses on their dendrites in the molecular layer (ML). EM and LM experiments in rats, and wild-type and GlyT2-GFP transgenic mice revealed that only one third of axon terminals establishing GABAergic synapses on GoC dendrites contain GlyT2, ruling out LuCs, globular cells, and any noncortical glycinergic inputs as major inhibitory sources. We also show that axon terminals of stellate/basket cells very rarely innervate GlyT2-GFP-expressing GoCs, indicating that only a minority of the inhibitory inputs to GoCs in the ML originates from local interneurons, and the majority of their inhibitory inputs exclusively releases GABA. true true 2016 803488 true true true false true false GOLD 2026-10-18 true https://doi.org/10.1523/ENEURO.0055-16.2016 true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 20 0 20 20 0 20 20 17 18 20 20 20 20 20 0 0 20 20 20 20 0 8 8 Folyóiratcikk Journal Article 24 18 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2017 0 2 2 2 2 2018 0 1 1 1 1 2019 0 2 2 2 2 2020 0 1 1 1 1 2021 0 5 5 5 5 2022 0 2 2 2 2 2023 0 1 1 1 1 2024 0 2 2 2 2 2025 0 3 3 3 3 2026 0 1 1 1 1 Q1 false false false false 2017-05-02T06:10:38.000+0000 2017-02-01T07:10:38.000+0000 Celluláris Idegélettani Kutatócsoport (HRN KOKI) 2 6 1 2 0 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 84968349 /api/authorship/84968349 1 0.0 true false true Author 10012932 /api/author/10012932 Eyre Mark David true 10012932 true Eyre MD true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84968348 /api/authorship/84968348 2 0.5 false true true Author 10000499 /api/author/10000499 Nusser Zoltán true 10000499 true Nusser Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 1151929 /api/publicationidentifier/1151929 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1523/ENEURO.0055-16.2016 https://doi.org/10.1523/ENEURO.0055-16.2016 false 1503376 true PublicationIdentifier 18722558 /api/publicationidentifier/18722558 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000391927300008 https://www.webofscience.com/wos/woscc/full-record/000391927300008 false true PublicationIdentifier 1151928 /api/publicationidentifier/1151928 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 85030483538 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85030483538 false 1724984 true PublicationIdentifier 1151930 /api/publicationidentifier/1151930 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 27257627 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27257627&dopt=Abstract false 1503377 true Classification 12125 /api/classification/12125 true true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 10947210 /api/sjrrating/10947210 570 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q1 DIRECT true true /api/publication/3150354 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10012932"><a href="/gui2/?type=authors&mode=browse&sel=10012932" target="_blank">Eyre MD ✉ (<span class="authorship-author-name">Eyre Mark David</span> <span class="authorAux-mtmt"> Neuroanatómia, idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z ✉ (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3150354" target="_blank">Only a Minority of the Inhibitory Inputs to Cerebellar Golgi Cells Originates from Local GABAergic Cells.</a></div> <div> <span class="journal-title">ENEURO</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2373-2822">2373-2822</a>)</span>: <span class="journal-volume">3</span> <span class="journal-issue">3</span> <span class="page"> pp 317-334 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1523/ENEURO.0055-16.2016" target="_blank" href="https://doi.org/10.1523/ENEURO.0055-16.2016"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000391927300008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000391927300008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85030483538" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85030483538"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="27257627" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27257627&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 20</span> | Independent citation: 20 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 17 | Number of citations in Scopus:&nbsp;18 | WoS/Scopus assigned:&nbsp;20 | Number of citations with DOI:&nbsp;20 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3150354&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3150354</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 3150354</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2021.04.28. 12:03 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :11 Export Date: 18 October 2022 Correspondence Address: Eyre, M.D.; Laboratory of Cellular Neurophysiology, Hungary Chemicals/CAS: tetrodotoxin, 4368-28-9, 4664-41-9; 4 aminobutyric acid, 28805-76-7, 56-12-2; gamma-Aminobutyric Acid; Receptors, GABA-A Funding details: Seventh Framework Prog...</pre> </div></div>