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U1703107, U1801288, and 21665013), the Natural Science Foundation of Tianjin, China (No. 19JCYBJC28100), Hundred Young Academic Leaders Program of Nankai University, and State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. GTZK201902).\nState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China \n College of Chemistry and Environmental Sciences, Kashgar University, Kashgar, 844000, China \n Department of Plant and Soil Sciences, University of Pretoria, Pretoria, 0002, South Africa \n Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, and Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China \n College of Life Sciences and 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