Blast exposure results in tau and neurofilament light chain changes in peripheral blood

Edwards, Katie A.; Leete, Jacqueline J.; Tschiffely, Anna E.; Moore, Candace Y.; Dell, Kristine C.; Statz, Jonathan K.; Carr, Walter; Walker, Peter B.; LoPresti, Matthew L.; Ahlers, Stephen T.; Yarnell, Angela M.; Gill, Jessica ✉

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: BRAIN INJURY 0269-9052 1362-301X 34 (9) pp. 1213-1221 2020
  • SJR Scopus - Developmental and Educational Psychology: Q2
Azonosítók
Szakterületek:
    Objectives To evaluate how blast exposure impacts peripheral biomarkers in military personnel enrolled in 10-day blast training. Methods On day 7, 21 military personnel experienced peak overpressure <2 pounds per square inch (psi); while 29 military personnel experienced peak overpressure >= 5 psi. Blood samples were collected each day to measure changes in amyloid beta (A beta), neurofilament light chain (NFL), and tau concentrations. Results Within 24 hours following exposure >= 5 psi, the >= 5 psi group had lower A beta 42 (p= .004) and NFL (p< .001) compared to the <2 psi group and lower A beta 42 (9.35%) and NFL (22.01%) compared to baseline. Twenty-four hours after >= 5 psi exposure, the >= 5 psi group had lower tau (p< .001) and NFL (p< .001) compared to the <2 psi group and baseline. Seventy-two hours after exposure >= 5 psi, tau increased in the >= 5 psi group compared to the <2 psi group (p= .02) and baseline. The tau:A beta 42 ratio 24 hours after blast (p= .012), and the A beta 40:A beta 42 ratio 48 hours after blast (p= .04) differed in the >= 5 psi group compared to the Conclusions These findings provide an initial report of acute alterations in biomarker concentrations following blast exposure.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-07-25 04:15