Retinal vein occlusion (RVO) is the second most common etiology for vision loss. There
is contrasting evidence on the association between diabetes mellitus (DM) and the
risk of RVO. We performed a meta-analysis of published articles before October 31,
2019, to estimate a pooled odds ratio for the association between DM and RVO, including
central and branch RVO by a fixed or random effects model. We identified 37 publications
from 38 studies (1 publication was from 2 studies), published between 1985 and 2019.
In total, 148,654 cases and 23,768,820 controls were included in this meta-analysis.
The results of pooled analysis for all 37 publications (or 38 studies) showed a significant
association between DM and the risk of RVO (OR = 1.68, 95% CI: 1.43-1.99). Subgroup
analysis indicated that DM was significantly associated with CRVO (OR = 1.98, 95%
CI: 1.29-3.03, I-2 = 67.9%), but not significantly associated with BRVO (OR = 1.22,
95% CI: 0.95-1.56, I-2 = 64.1%). In conclusion, the result of present meta-analysis
suggested that DM is a risk factor for RVO. More well-designed studies on the relationship
between RVO and DM should be undertaken in the future.