{ "labelLang" : "hun", "responseDate" : "2024-03-28 17:16", "content" : { "otype" : "JournalArticle", "mtid" : 31467801, "status" : "ADMIN_APPROVED", "published" : true, "comment" : "Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden \n Department of Otorhinolaryngology, Head and Neck Surgery, Karolinska University Hospital, Stockholm, Sweden \n Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden \n Department of Surgical and Perioperative Sciences, Urology and Andrology Unit, Umeå University, Umeå, Sweden \n Departement of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel \n Departement of Clinical Pathology and Cytology, Cancer, Center Karolinska, R8:02, Karolinska University hospital, Stockholm, Sweden \n Cited By :1 \n Export Date: 19 February 2021 \n CODEN: HEANE \n Correspondence Address: Ramqvist, T.; Department of Clinical Science, Sweden; email: torbjorn.ramqvist@ki.se \n Correspondence Address: Ramqvist, T.; Department of Oncology-Pathology, Sweden; email: torbjorn.ramqvist@ki.se \n Chemicals/CAS: epithelial derived neutrophil activating factor 78, 136956-40-6; gamma interferon inducible protein 10, 97741-20-3; interleukin 12, 138415-13-1; interleukin 13, 148157-34-0; interleukin 8, 114308-91-7; macrophage inflammatory protein 1alpha, 155075-84-6; macrophage inflammatory protein 1beta, 122071-81-2; macrophage inflammatory protein 3alpha, 177404-38-5; monocyte chemotactic protein 4, 173146-42-4, 177346-98-4; thymus and activation regulated chemokine, 181532-29-6 \n Funding details: 253 \n Funding details: 20180085, 2018037 \n Funding details: Swedish Cancer Foundation, 180440 \n Funding details: Cancerföreningen i Stockholm, 151253, 181053 \n Funding text 1: The authors would like to acknowledge support of the Clinical biomarker facility at SciLifeLab Sweden for providing assistance in protein analysis. We thank Susanne Becker, Inger Bodin, and Anna Malmerfelt for excellent technical assistance and Ola Hössjer for advice regarding data analysis. This work was supported by the Cancer Society in Stockholm (151253, 181053), The Swedish Cancer Foundation (180440), the Stockholm County ALF (20180085, 2018037), Laryngfonden and the Cancer and Allergy Foundation (253). Anders Näsman was supported by Region Stockholm (clinical postdoctoral appointment). The funding sources had no involvement in any part of the study.", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-01-09T17:30:51.413+0000", "lastModified" : "2021-02-10T12:55:43.864+0000", "created" : "2020-08-28T05:13:49.939+0000", "creator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "lastDuplumOK" : "2022-01-09T17:12:38.152+0000", "lastDuplumSearch" : "2022-01-09T17:12:38.152+0000", "adminApproved" : "2021-02-10T12:55:43.873+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10062250, "link" : "/api/admin/10062250", "label" : "Molnár-Taga Márta (SE 4-es admin)", "familyName" : "Molnár-Taga", "givenName" : "Márta", "published" : true, "oldId" : 10062250, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Landin, David", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 92724712, "link" : "/api/authorship/92724712", "label" : "Landin, David", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Landin", "givenName" : "David", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724713, "link" : "/api/authorship/92724713", "label" : "Ahrlund-Richter, Andreas", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Ahrlund-Richter", "givenName" : "Andreas", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724714, "link" : "/api/authorship/92724714", "label" : "Mirzaie, Leila", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Mirzaie", "givenName" : "Leila", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724715, "link" : "/api/authorship/92724715", "label" : "Mints, Michael", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Mints", "givenName" : "Michael", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724716, "link" : "/api/authorship/92724716", "label" : "Nasman, Anders", "listPosition" : 5, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Nasman", "givenName" : "Anders", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724717, "link" : "/api/authorship/92724717", "label" : "Kolev, Aeneas", "listPosition" : 6, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Kolev", "givenName" : "Aeneas", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724718, "link" : "/api/authorship/92724718", "label" : "Marklund, Linda", "listPosition" : 7, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Marklund", "givenName" : "Linda", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724719, "link" : "/api/authorship/92724719", "label" : "Dalianis, Tina", "listPosition" : 8, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Dalianis", "givenName" : "Tina", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724720, "link" : "/api/authorship/92724720", "label" : "Munck-Wikland, Eva", "listPosition" : 9, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Munck-Wikland", "givenName" : "Eva", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 92724721, "link" : "/api/authorship/92724721", "label" : "Ramqvist, Torbjorn ✉", "listPosition" : 10, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Ramqvist", "givenName" : "Torbjorn", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Immune related proteins and tumor infiltratingCD8+lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 17326494, "link" : "/api/publicationidentifier/17326494", "label" : "DOI: 10.1002/hed.26364", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.1002/hed.26364", "realUrl" : "https://doi.org/10.1002%2Fhed.26364", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 17326493, "link" : "/api/publicationidentifier/17326493", "label" : "WoS: 000544628700001", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=@@@&DestApp=WOS", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000544628700001", "realUrl" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000544628700001&DestApp=WOS", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 17326495, "link" : "/api/publicationidentifier/17326495", "label" : "Scopus: 85087293541", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85087293541", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85087293541", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 1749, "link" : "/api/journal/1749", "label" : "HEAD AND NECK : JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 1043-3074 1097-0347", "pIssn" : "1043-3074", "eIssn" : "1097-0347", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 1749, "snippet" : true }, "volume" : "42", "issue" : "11", "firstPage" : "3206", "lastPage" : "3217", "firstPageOrInternalIdForSort" : "3206", "pageLength" : 12, "publishedYear" : 2020, "abstractText" : "Background Hypopharyngeal cancer (HPSCC) shows a poor clinical outcome, while HPSCC, caused by human papillomavirus (HPV), presents a better outcome. Here, HPCC, immune proteins, and tumor infiltrating CD8+ lymphocytes (CD8+ TILs) were evaluated in relation to HPV and outcome. Methods Fresh frozen tissue from four HPV-positive HPSCC, 39 HPV-negative HPSCC, and normal samples were analyzed for protein expression by the Proseek immuno-oncology immunoassay. CD8+ TIL numbers evaluated by immunohistochemistry on 144 formalin-fixed biopsies were analyzed in relation to clinical outcome. Results Proteins differing between HPV-positive and negative HPSCC included CD8A, PD-L1, Fas ligand, and chemokines. High CD8+ TIL numbers were correlated to improve clinical outcome in HPV-negative HPSCC. Conclusions High expression of immune proteins in HPV-positive HPSCC may explain the better clinical outcome. CD8+ TILs are of relevance for outcome of HPV-negative HPSCC, while tumors with high immune activity but poor patient survival suggest a role for immune therapy.", "subjects" : [ { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 14328, "link" : "/api/keyword/14328", "label" : "protein expression", "published" : true, "oldId" : 14328, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1036358, "link" : "/api/keyword/1036358", "label" : "Clinical outcome", "published" : true, "oldId" : 1036358, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1067310, "link" : "/api/keyword/1067310", "label" : "human papillomavirus", "published" : true, "oldId" : 1067310, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1563408, "link" : "/api/keyword/1563408", "label" : "Hypopharyngeal cancer", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2082541, "link" : "/api/keyword/2082541", "label" : "CD8-positive lymphocytes", "published" : true, "snippet" : true } ], "digital" : true, "printed" : true, "sourceYear" : 2020, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : false, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2022-01-09", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10869589, "link" : "/api/sjrrating/10869589", "label" : "sjr:Q1 (2020) Scopus - Otorhinolaryngology HEAD AND NECK : JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 1043-3074 1097-0347", "listPos" : 14, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2733, "link" : "/api/classificationexternal/2733", "label" : "Scopus - Otorhinolaryngology", "published" : true, "oldId" : 2733, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2021-02-09T12:55:43.351+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 10, "ownerInstituteCount" : 22, "directInstituteCount" : 0, "authorCount" : 10, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/31467801", "label" : "Landin David et al. Immune related proteins and tumor infiltratingCD8+lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome. (2020) HEAD AND NECK : JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 1043-3074 1097-0347 42 11 3206-3217", "template" : "