{ "labelLang" : "hun", "responseDate" : "2024-03-28 14:07", "content" : { "otype" : "JournalArticle", "mtid" : 31461093, "status" : "APPROVED", "published" : true, "comment" : "Sensory Science Metabolism Unit, Biobehavioral Branch, National Institute of Nursing Research, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States \n College of Nursing, University of Missouri-St. Louis, St. Louis, MO, United States \n National Institutes of Health Library, Office of Research, Services, OD, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, United States \n Export Date: 23 November 2020 \n Correspondence Address: Joseph, P.V.; Sensory Science Metabolism Unit, Biobehavioral Branch, National Institute of Nursing Research, Division of Intramural Research, National Institutes of Health, Department of Health and Human ServicesUnited States; email: paule.joseph@nih.gov\nSensory Science Metabolism Unit, Biobehavioral Branch, National Institute of Nursing Research, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States \n College of Nursing, University of Missouri-St. Louis, St. Louis, MO, United States \n National Institutes of Health Library, Office of Research, Services, OD, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, United States \n Export Date: 15 December 2020 \n Correspondence Address: Joseph, P.V.; Sensory Science Metabolism Unit, Biobehavioral Branch, National Institute of Nursing Research, Division of Intramural Research, National Institutes of Health, Department of Health and Human ServicesUnited States; email: paule.joseph@nih.gov \n Chemicals/CAS: alkaline phosphatase, 9001-78-9; gamma interferon, 82115-62-6; palmitic acid, 57-10-3; peroxisome proliferator activated receptor alpha, 147258-70-6; toll like receptor 4, 203811-83-0 \n Funding details: National Institute of Nursing Research, NINR \n Funding details: U.S. Department of Health and Human Services, HHS, 1ZIANR000035-01 \n Funding details: National Institutes of Health, NIH \n Funding details: Rockefeller University \n Funding text 1: The authors gratefully acknowledge the following: Dr. Joan K. Austin (National Institute of Nursing Research) and Dr. Rosario Jaime-Lara (National Institute of Nursing Research) for reviewing and editing this article; and Alan Hoofring, MS, MA (Medical Arts Branch, Office of Research Services, National Institutes of Health) for his assistance with figure design and illustration. Funding. SC was supported by an Intramural Research Training Award, Office of Intramural Training & Education, National Institutes of Health, Department of Health and Human Services. PJ was supported by the National Institute of Nursing Research under award number 1ZIANR000035-01. PJ is also supported by the Office of Workforce Diversity, National Institutes of Health and the Rockefeller University Heilbrunn Nurse Scholar Award.\nSensory Science Metabolism Unit, Biobehavioral Branch, National Institute of Nursing Research, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States \n College of Nursing, University of Missouri-St. Louis, St. Louis, MO, United States \n National Institutes of Health Library, Office of Research, Services, OD, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, United States \n Export Date: 19 January 2021 \n Correspondence Address: Joseph, P.V.; Sensory Science Metabolism Unit, Biobehavioral Branch, National Institute of Nursing Research, Division of Intramural Research, National Institutes of Health, Department of Health and Human ServicesUnited States; email: paule.joseph@nih.gov \n Chemicals/CAS: alkaline phosphatase, 9001-78-9; gamma interferon, 82115-62-6; palmitic acid, 57-10-3; peroxisome proliferator activated receptor alpha, 147258-70-6; toll like receptor 4, 203811-83-0 \n Funding details: National Institute of Nursing Research, NINR \n Funding details: U.S. Department of Health and Human Services, HHS, 1ZIANR000035-01 \n Funding details: National Institutes of Health, NIH \n Funding details: Rockefeller University \n Funding text 1: The authors gratefully acknowledge the following: Dr. Joan K. Austin (National Institute of Nursing Research) and Dr. Rosario Jaime-Lara (National Institute of Nursing Research) for reviewing and editing this article; and Alan Hoofring, MS, MA (Medical Arts Branch, Office of Research Services, National Institutes of Health) for his assistance with figure design and illustration. Funding. SC was supported by an Intramural Research Training Award, Office of Intramural Training & Education, National Institutes of Health, Department of Health and Human Services. PJ was supported by the National Institute of Nursing Research under award number 1ZIANR000035-01. 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Understanding the role of EVs in regulation of beta-cell function and viability may provide insights into diabetes etiology and may lead to the development of more effective screening and diagnostic tools to detect diabetes earlier and prevent disease progression. This review was conducted to determine what is known from the literature about the effect of EV crosstalk on pancreatic beta-cell function and viability in the pathogenesis of diabetes mellitus, to perform a gap analysis for future research directions, and to discuss implications of available evidence for diabetes care. The literature search yielded 380 studies from which 31 studies were determined to meet eligibility criteria. The majority of studies had the disease context of autoimmunity in T1DM. The most commonly studied EV crosstalk dynamics involved localized EV-mediated communication between beta-cells and other islet cells, or between beta-cells and immune cells. Other organs and tissues secreting EVs that affect beta-cells include skeletal muscle, hepatocytes, adipocytes, immune cells, bone marrow, vascular endothelium, and mesenchymal stem cells. Characterization of EV cargo molecules with regulatory effects in beta-cells was conducted in 24 studies, with primary focus on microRNA cargo. Gaps identified included scarcity of evidence for the effect on beta-cell function and viability of EVs from major metabolic organs/tissues such as muscle, liver, and adipose depots. 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