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In this paper, the effect of low molecular weight heparin sodium and low dose progesterone on threatened abortion was studied. The patients in the experimental group were treated with low-molecular-weight heparin and low-dose progesterone. The clinical symptom relief time and adverse reactions were compared between the two groups. Results compared with the control group, the incidence of adverse reactions in the experimental group was 4% lower than that in the control group (23%), and the difference between the two groups was statistically significant; compared with the control group, the relief time of clinical symptoms in the experimental group was shorter than that in the control group (P<0.05)) The combination of low molecular weight heparin sodium and low dose progesterone in the treatment of threatened abortion has significant clinical effect, which can comprehensively improve the clinical symptoms of patients. 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