https://m2.mtmt.hu/ eng 2026-10-23 06:53 JournalArticle 3143505 VALIDATED true 0 2018-02-20T16:44:46.000+0000 false 3143505 2026-10-17T22:53:00.310+0000 2025-01-02T15:13:31.778+0000 2016-11-25T12:32:47.000+0000 true 10008942 Sperlágh Beáta /api/author/10008942 Author true 10008942 2026-01-12T09:29:39.278+0000 2026-01-12T09:29:39.278+0000 2025-01-02T15:13:32.058+0000 true 10003132 Balázs András /api/admin/10003132 Admin true 10003132 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10003132 /api/admin/10003132 Balázs András true 10003132 true 2024-10-17T16:47:09.541+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kovanyi, B The role of P2X7 receptors in a rodent PCP-induced schizophrenia model true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 6 36680 36680 16 2016 P2X7 receptors (P2X7Rs) are ligand-gated ion channels sensitive to extracellular ATP. Here we examined for the first time the role of P2X7R in an animal model of schizophrenia. Using the PCP induced schizophrenia model we show that both genetic deletion and pharmacological inhibition of P2X7Rs alleviate schizophrenia-like behavioral alterations. In P2rx7+/+ mice, PCP induced hyperlocomotion, stereotype behavior, ataxia and social withdrawal. In P2X7 receptor deficient mice (P2rx7-/-), the social interactions were increased, whereas the PCP induced hyperlocomotion and stereotype behavior were alleviated. The selective P2X7 receptor antagonist JNJ-47965567 partly replicated the effect of gene deficiency on PCP-induced behavioral changes and counteracted PCP-induced social withdrawal. We also show that PCP treatment upregulates and increases the functional responsiveness of P2X7Rs in the prefrontal cortex of young adult animals. The amplitude of NMDA evoked currents recorded from layer V pyramidal neurons of cortical slices were slightly decreased by both genetic deletion of P2rx7 and by JNJ-47965567. PCP induced alterations in mRNA expression encoding schizophrenia-related genes, such as NR2A, NR2B, neuregulin 1, NR1 and GABA alpha1 subunit were absent in the PFC of young adult P2rx7-/- animals. Our findings point to P2X7R as a potential therapeutic target in schizophrenia. true true 2016 725090 true true true false true false GOLD 2026-10-18 true https://doi.org/10.1038/srep36680 true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 46 0 46 30 14 46 46 45 46 46 46 30 30 30 16 0 46 30 46 30 0 11 11 Folyóiratcikk Journal Article 24 45 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat 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1000 true D1 DIRECT true true /api/publication/3143505 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10057984"><a href="/gui2/?type=authors&mode=browse&sel=10057984" target="_blank">Kovanyi B (<span class="authorship-author-name">Koványi Bence</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology; <span title="Semmelweis University">SU</span>/School of Ph. D. Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="228"><a href="/gui2/?type=authors&mode=browse&sel=228" target="_blank">Csolle C (<span class="authorship-author-name">Csölle Cecília</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052972"><a href="/gui2/?type=authors&mode=browse&sel=10052972" target="_blank">Calovi S (<span class="authorship-author-name">Calovi Stefano</span> <span class="authorAux-mtmt"> Biology (neuroscience)</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039322"><a href="/gui2/?type=authors&mode=browse&sel=10039322" target="_blank">Hanuska A (<span class="authorship-author-name">Hanuska Adrienn</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015479"><a href="/gui2/?type=authors&mode=browse&sel=10015479" target="_blank">Kato E (<span class="authorship-author-name">Kató Erzsébet</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015482"><a href="/gui2/?type=authors&mode=browse&sel=10015482" target="_blank">Koles L (<span class="authorship-author-name">Köles László</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bhattacharya A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011498"><a href="/gui2/?type=authors&mode=browse&sel=10011498" target="_blank">Haller J (<span class="authorship-author-name">Haller József</span> <span class="authorAux-mtmt"> Magatartás neurobiológiája, Kriminálpszichológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh B ✉ (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3143505" target="_blank">The role of P2X7 receptors in a rodent PCP-induced schizophrenia model</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">6</span> <span class="page"> Paper 36680. 16 p. </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/srep36680" target="_blank" href="https://doi.org/10.1038/srep36680"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000387324200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000387324200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84994460534" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84994460534"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27824163" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27824163&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 46</span> | Independent citation: 30 | Self citation: 16 | Unknown citation: 0 | Number of citations in WoS: 45 | Number of citations in Scopus:&nbsp;46 | WoS/Scopus assigned:&nbsp;46 | Number of citations with DOI:&nbsp;46 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3143505&sort=publishedYear,desc&sort=title"> Number of cited publications: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3143505</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3143505</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.01.02. 16:13 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:47 Gusztáv Ladányi (MTMT API user, admin) András Balázs (MTMT Központ, admin) </div> </div></div>