https://m2.mtmt.hu/ hun 2026-09-22 10:13 JournalArticle 31428172 APPROVED true Cited By :20 Export Date: 14 December 2021 CODEN: CMRED Correspondence Address: Timar, J.; 2nd Department of Pathology, Hungary; email: jtimar@gmail.com Chemicals/CAS: protein p21, 85306-28-1; KRAS protein, human; Proto-Oncogene Proteins p21(ras) Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K-116151, KTIA-NAPB-2017-1.2.1-NKP-0002, NVKP-16-1-2016-0004, NVKP-16-1-2016-0020 Funding text 1: This work was supported by NKFIH grants: NVKP-16-1-2016-0020, NVKP-16-1-2016-0004, K-116151, KTIA-NAPB-2017-1.2.1-NKP-0002. 0 false 2026-08-18T11:04:40.667+0000 2022-03-09T08:11:14.865+0000 2020-08-26T03:56:54.554+0000 true 565 WoS import /api/admin/565 Admin true 2025-01-15T11:40:21.997+0000 2021-01-06T10:16:25.554+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Timar, Jozsef Molecular epidemiology and diagnostics of KRAS mutations in human cancer true true /api/journal/911 REVIEWED true false 911 false 911 true 0167-7659 1573-7233 Journal FOREIGN 39 4 1029 1038 1029 10 2020 RAS mutation is the most frequent oncogenic alteration in human cancers. KRAS is the most frequently mutated followed by NRAS. The emblematic KRAS mutant cancers are pancreatic, colorectal, lung adenocarcinomas and urogenital cancers. KRAS mutation frequencies are relatively stable worldwide in various cancer types with the one exception of lung adenocarcinoma. The frequencies of KRAS variant alleles appears cancer type specific, reflecting the various carcinogenic processes. In addition to point mutation KRAS, allelic imbalances are also frequent in human cancers leading to the predominance of a mutant allele. KRAS mutant cancers are characterized by typical, cancer-type-specific co-occurring mutations and distinct gene expression signatures. The heterogeneity of KRAS mutant primary cancers is significant, affecting the variant allele frequency, which could lead to unpredictable branching development in metastases. Selection of minute mutant subclones in the primary tumors or metastases during target therapies can also occur frequently in lung or colorectal cancers leading to acquired resistance. Ultrahigh sensitivity techniques are now routinely available for diagnostic purposes, but the proper determination of mutant allele frequency of KRAS in the primary or metastatic tissues may have larger clinical significance. true true 2020 true true true false true false NONE 2026-08-18 false 260 0 260 254 7 260 258 256 141 260 260 254 254 254 6 0 260 254 260 254 0 6 6 Folyóiratcikk Journal Article 24 260 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 1 1 1 1 2021 0 20 20 20 20 2022 0 42 42 42 42 2023 0 54 54 54 54 2024 0 67 62 67 62 2025 0 53 53 53 53 2026 0 23 22 23 22 Q1 false false false false 2021-01-05T10:16:25.236+0000 II. 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Patológiai Intézet (SE / AOK / I) 1 9 1 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 92461383 /api/authorship/92461383 1 0.5 true false true Author 10000584 /api/author/10000584 Tímár József true 10000584 true Timar Jozsef true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 92461384 /api/authorship/92461384 2 0.5 false true false Kashofer Karl true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 17191287 /api/publicationidentifier/17191287 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s10555-020-09915-5 https://doi.org/10.1007/s10555-020-09915-5 false true PublicationIdentifier 17191286 /api/publicationidentifier/17191286 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000553942100001 https://www.webofscience.com/wos/woscc/full-record/000553942100001 false true PublicationIdentifier 17191288 /api/publicationidentifier/17191288 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85088991574 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85088991574 false true PublicationIdentifier 17191289 /api/publicationidentifier/17191289 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 32725342 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32725342&dopt=Abstract false true Classification 12215 /api/classification/12215 true true Keyword 9779 /api/keyword/9779 true 9779 true Keyword 12792 /api/keyword/12792 true 12792 true Keyword 1052052 /api/keyword/1052052 true 1052052 true Keyword 1176663 /api/keyword/1176663 true 1176663 true Keyword 1558263 /api/keyword/1558263 true true SjrRating 10984562 /api/sjrrating/10984562 30 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true Q1 DIRECT true true /api/publication/31428172 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000584"><a href="/gui2/?type=authors&mode=browse&sel=10000584" target="_blank">Timar Jozsef ✉ (<span class="authorship-author-name">Tímár József</span> <span class="authorAux-mtmt"> Rákkutatás, daganatpathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. 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Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kashofer Karl </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31428172" target="_blank">Molecular epidemiology and diagnostics of KRAS mutations in human cancer</a></div> <div> <span class="journal-title">CANCER AND METASTASIS REVIEWS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0167-7659">0167-7659</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1573-7233">1573-7233</a>)</span>: <span class="journal-volume">39</span> <span class="journal-issue">4</span> <span class="page"> pp 1029-1038 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s10555-020-09915-5" target="_blank" href="https://doi.org/10.1007/s10555-020-09915-5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000553942100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000553942100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85088991574" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85088991574"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32725342" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32725342&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 260</span> | Független: 254 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 256 | Scopus jelölt:&nbsp;141 | WoS/Scopus jelölt:&nbsp;260 | DOI jelölt:&nbsp;258 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31428172&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31428172</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2022.03.09. 09:11 Pirmann Tamás (OOI addmin5, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :20 Export Date: 14 December 2021 CODEN: CMRED Correspondence Address: Timar, J.; 2nd Department of Pathology, Hungary; email: jtimar@gmail.com Chemicals/CAS: protein p21, 85306-28-1; KRAS protein, human; Proto-Oncogene Proteins p21(ras) Funding details: Nemzeti Kutat...</pre> </div></div>