The influence of intracranial hypertension on static cerebral autoregulation

de-Lima-Oliveira, Marcelo ✉; Ferreira, Almir Andrade; Belon, Alessandro Rodrigo; Salinet, Angela Macedo; Nogueira, Ricardo Carvalho; Ping, Brasil Chian; Paiva, Wellingson Silva; Teixeira, Manoel Jacobsen; Bor-Seng-Shu, Edson

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: BRAIN INJURY 0269-9052 1362-301X , 7 p. 2020
  • SJR Scopus - Developmental and Educational Psychology: Q2
    Objectives To analyze the influences of mild and severe intracranial hypertension on cerebral autoregulation (CA). Patients and Methods Duroc piglets were monitored with an intracranial pressure (ICP) catheter. Intracranial hypertension was induced via infusion of 4 or 7 ml of saline solution by a bladder catheter that was inserted into the parietal lobe. The static cerebral autoregulation (sCA) index was evaluated via cerebral blood flow velocities (CBFv). Piglets with ICPs <= 25 and > 25 mmHg were considered as group 1 and 2, respectively. Continuous variables were evaluated using the Kolmogorov-Smirnov goodness-of-fit test. The main parameters were collected before and after ICH induction and compared using two-factor mixed-design ANOVAs with the factor of experimental group (mild and severe ICH). Results In group 1 (ICP <= 25 mmHg), there were significant differences in sCA (p= .01) and ICP (p= .0002) between the basal and balloon inflation conditions. In group 2 (ICP > 25 mmHg), there were significant differences in CBFv (p= .0072), the sCA index (p= .0001) and ICP (p= .00001) between the basal and balloon inflation conditions. Conclusion We conclude that ICH may have a direct effect on mild and severe sCA.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-07-26 02:53