{ "labelLang" : "hun", "responseDate" : "2024-03-29 09:46", "content" : { "otype" : "JournalArticle", "mtid" : 31411655, "status" : "VALIDATED", "published" : true, "comment" : "Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, Brno, 62500, Czech Republic \n Department of Chemistry and Toxicology, Veterinary Research Institute, Hudcova 70, Brno, 62100, Czech Republic \n Department of Biosciences and Nutrition, Neo, Blickagången 16, SE-141 83 Huddinge, Sweden \n Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, 62500, Czech Republic \n Department of Cell and Molecular Biology, Biomedicum, Solnavägen 9, SE-171 65 Solna, Sweden \n Cited By :2 \n Export Date: 24 March 2021 \n Correspondence Address: Večeřa, J.; Department of Experimental Biology, Kamenice 5, Czech Republic; email: vecera@sci.muni.cz \n Funding details: MUNI/A/1397/2019 \n Funding details: MUNI/G/1131/2017 \n Funding details: ROZV/24/LF/2018, ROZV/25/LF/2017 \n Funding details: 18-25429Y \n Funding details: Åke Wiberg Stiftelse \n Funding details: Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT, CZ.02.1.01/0.0/0.0/15_003/0000495 \n Funding details: Grantová Agentura České Republiky, GA ČR, 15-13443Y, 17-05466S \n Funding details: Ministerio de Educación, Cultura y Deporte, MECD \n Funding details: Karolinska Institutet, KI \n Funding details: Vetenskapsrådet, VR \n Funding details: Central European Institute of Technology, CEITEC \n Funding details: Masarykova Univerzita, MU \n Funding details: Neuron Nadační Fond Na Podporu Vědy, Neuron \n Funding text 1: This research was supported by the Czech Science Foundation (GACR) (Project 15-13443Y) (principal investigator: Josef Ve?e?a), Ji?? Pachern?k was supported by the Czech Science Foundation (Project 17-05466S) and by the Faculty of Science of Masaryk University (MUNI/A/1397/2019). Hana Paculov? was supported by the Ministry of Education, Youth and Sports OPVVV PO1 project ?FIT? (CZ.02.1.01/0.0/0.0/15_003/0000495). Work in Andersson's (ERA) lab was supported by the Swedish Research Council, ?ke Wiberg Foundation, Jeansson Foundation, Karolinska Institutet, StratNeuro and ?hlen Foundation. Jan Ma?ek was supported by a fellowship from the WennerGren Foundation and by the Sheila Sherlock award (EASL). D??a Boha?iakov? was supported by GACR (Project 18-25429Y), by funds from NF Neuron, funds from Medical Faculty MU to Junior researcher (ROZV/25/LF/2017, ROZV/24/LF/2018) and by Grant Agency of Masaryk University (GAMU; MUNI/G/1131/2017). We would like to thank Dr. Ji?? Kohoutek and Dr. Miroslav Machala (Veterinary Research Institute, Brno) for technical support with chromatin immunoprecipitation experiments. We would also like to thank Dr. Michal ?m?da from the research group of Functional Genomics, (CEITEC, Masaryk University, Brno) for the access to the virus-lab. \n Funding text 2: This research was supported by the Czech Science Foundation ( GACR ) (Project 15-13443Y ) (principal investigator: Josef Večeřa), Jiří Pacherník was supported by the Czech Science Foundation (Project 17-05466S ) and by the Faculty of Science of Masaryk University (MUNI/A/1397/2019). Hana Paculová was supported by the Ministry of Education, Youth and Sports OPVVV PO1 project “FIT” ( CZ.02.1.01/0.0/0.0/15_003/0000495 ). Work in Andersson's (ERA) lab was supported by the Swedish Research Council , Åke Wiberg Foundation , Jeansson Foundation , Karolinska Institutet , StratNeuro and Åhlen Foundation . Jan Mašek was supported by a fellowship from the WennerGren Foundation and by the Sheila Sherlock award ( EASL ). Dáša Bohačiaková was supported by GACR (Project 18-25429Y ), by funds from NF Neuron, funds from Medical Faculty MU to Junior researcher ( ROZV/25/LF/2017, ROZV/24/LF/2018 ) and by Grant Agency of Masaryk University (GAMU; MUNI/G/1131/2017 ). We would like to thank Dr. Jiří Kohoutek and Dr. Miroslav Machala (Veterinary Research Institute, Brno) for technical support with chromatin immunoprecipitation experiments. We would also like to thank Dr. Michal Šmída from the research group of Functional Genomics, (CEITEC, Masaryk University, Brno) for the access to the virus-lab.\nDepartment of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, Brno, 62500, Czech Republic \n Department of Chemistry and Toxicology, Veterinary Research Institute, Hudcova 70, Brno, 62100, Czech Republic \n Department of Biosciences and Nutrition, Neo, Blickagången 16, SE-141 83 Huddinge, Sweden \n Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, 62500, Czech Republic \n Department of Cell and Molecular Biology, Biomedicum, Solnavägen 9, SE-171 65 Solna, Sweden \n Cited By :4 \n Export Date: 21 April 2021 \n Correspondence Address: Večeřa, J.; Department of Experimental Biology, Kamenice 5, Czech Republic; email: vecera@sci.muni.cz \n Funding details: MUNI/A/1397/2019 \n Funding details: MUNI/G/1131/2017 \n Funding details: ROZV/24/LF/2018, ROZV/25/LF/2017 \n Funding details: 18-25429Y \n Funding details: Åke Wiberg Stiftelse \n Funding details: Jeanssons Stiftelser \n Funding details: Allen Foundation \n Funding details: Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT, CZ.02.1.01/0.0/0.0/15_003/0000495 \n Funding details: Grantová Agentura České Republiky, GA ČR, 15-13443Y, 17-05466S \n Funding details: Karolinska Institutet, KI \n Funding details: Vetenskapsrådet, VR \n Funding details: Central European Institute of Technology, CEITEC \n Funding details: Masarykova Univerzita, MU \n Funding details: Neuron Nadační Fond Na Podporu Vědy, Neuron \n Funding details: Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy, PIWet-PIB \n Funding text 1: This research was supported by the Czech Science Foundation (GACR) (Project 15-13443Y) (principal investigator: Josef Ve?e?a), Ji?? Pachern?k was supported by the Czech Science Foundation (Project 17-05466S) and by the Faculty of Science of Masaryk University (MUNI/A/1397/2019). Hana Paculov? was supported by the Ministry of Education, Youth and Sports OPVVV PO1 project ?FIT? (CZ.02.1.01/0.0/0.0/15_003/0000495). Work in Andersson's (ERA) lab was supported by the Swedish Research Council, ?ke Wiberg Foundation, Jeansson Foundation, Karolinska Institutet, StratNeuro and ?hlen Foundation. Jan Ma?ek was supported by a fellowship from the WennerGren Foundation and by the Sheila Sherlock award (EASL). D??a Boha?iakov? was supported by GACR (Project 18-25429Y), by funds from NF Neuron, funds from Medical Faculty MU to Junior researcher (ROZV/25/LF/2017, ROZV/24/LF/2018) and by Grant Agency of Masaryk University (GAMU; MUNI/G/1131/2017). We would like to thank Dr. Ji?? Kohoutek and Dr. Miroslav Machala (Veterinary Research Institute, Brno) for technical support with chromatin immunoprecipitation experiments. We would also like to thank Dr. Michal ?m?da from the research group of Functional Genomics, (CEITEC, Masaryk University, Brno) for the access to the virus-lab. \n Funding text 2: This research was supported by the Czech Science Foundation ( GACR ) (Project 15-13443Y ) (principal investigator: Josef Večeřa), Jiří Pacherník was supported by the Czech Science Foundation (Project 17-05466S ) and by the Faculty of Science of Masaryk University (MUNI/A/1397/2019). Hana Paculová was supported by the Ministry of Education, Youth and Sports OPVVV PO1 project “FIT” ( CZ.02.1.01/0.0/0.0/15_003/0000495 ). Work in Andersson's (ERA) lab was supported by the Swedish Research Council , Åke Wiberg Foundation , Jeansson Foundation , Karolinska Institutet , StratNeuro and Åhlen Foundation . Jan Mašek was supported by a fellowship from the WennerGren Foundation and by the Sheila Sherlock award ( EASL ). 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Since the process of neurogenesis occurs in a hypoxic environment, the question arises of how NSCs deal with low oxygen tension and whether it a ffects their stemness. Genes from the hypoxia-inducible factors (HIF) family are well known factors governing cellular response to hypoxic conditions. In this study, we have discovered that the endogenous stabilization of hypoxia- inducible factor 1 alpha (Hif1 ?) during neural induction is critical for the normal development of the NSCs pool by preventing its premature depletion and di fferentiation. The knock-out of the Hif1 alpha gene in mESC-derived neu- rospheres led to a decrease in self-renewal of NSCs, paralleled by an increase in neuronal di fferentiation. Similarly, neuroepithelial cells di fferentiated in hypoxia exhibited accelerated neurogenesis soon after Hif1 alpha knock-down. In both models, the loss of Hif1 alpha was accompanied by an immediate drop in neural repressor Hes1 levels while changes in Notch signaling were not observed. We found that active Hif1 alpha/Arnt1 transcription complex bound to the evolutionarily conserved site in Hes1 gene promoter in both neuroepithelial cells and neural tissue of E8.5- 9.5 embryos. 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