https://m2.mtmt.hu/ eng 2026-10-24 18:52 JournalArticle 31411636 APPROVED true 0 false 2026-10-20T15:38:04.572+0000 2025-08-04T13:11:37.239+0000 2020-08-25T10:13:48.912+0000 true 565 WoS import /api/admin/565 Admin true 2025-10-28T13:01:11.651+0000 2025-10-28T13:01:11.651+0000 2020-09-24T11:26:28.765+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Olah, Viktor Janos Functional specification of CCK plus interneurons by alternative isoforms of Kv4.3 auxiliary subunits true true /api/journal/10031024 REVIEWED true false 10031024 false 10031024 true 2050-084X Journal FOREIGN 9 e58515 e58515 26 2020 CCK-expressing interneurons (CCK+INs) are crucial for controlling hippocampal activity. We found two firing phenotypes of CCK+INs in rat hippocampal CA3 area; either possessing a previously undetected membrane potential-dependent firing or regular firing phenotype, due to different low-voltage-activated potassium currents. These different excitability properties destine the two types for distinct functions, because the former is essentially silenced during realistic 8-15 Hz oscillations. By contrast, the general intrinsic excitability, morphology and gene-profiles of the two types were surprisingly similar. Even the expression of Kv4.3 channels were comparable, despite evidences showing that Kv4.3-mediated currents underlie the distinct firing properties. Instead, the firing phenotypes were correlated with the presence of distinct isoforms of Kv4 auxiliary subunits (KChIP1 vs. KChIP4e and DPP6S). Our results reveal the underlying mechanisms of two previously unknown types of CCK+INs and demonstrate that alternative splicing of few genes, which may be viewed as a minor change in the cells' whole transcriptome, can determine cell-type identity. 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0.125 false false false Author 156 /api/author/156 Arszovszki Antónia true 156 true Arszovszki Antonia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 92352660 /api/authorship/92352660 5 0.125 false false false Author 10012931 /api/author/10012931 Lőrincz Andrea true 10012931 true Lorincz Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 92352661 /api/authorship/92352661 6 0.125 false false false Author 10000499 /api/author/10000499 Nusser Zoltán true 10000499 true Nusser Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 92352662 /api/authorship/92352662 7 0.125 false false false Foldy Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 92352663 /api/authorship/92352663 8 0.125 false true true Author 215 /api/author/215 Szabadics János true 215 true Szabadics Janos true false 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062706"><a href="/gui2/?type=authors&mode=browse&sel=10062706" target="_blank">Olah Viktor Janos (<span class="authorship-author-name">Oláh Viktor János</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Cellular Neuropharmacology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukacsovich David </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Winterer Jochen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="156"><a href="/gui2/?type=authors&mode=browse&sel=156" target="_blank">Arszovszki Antonia (<span class="authorship-author-name">Arszovszki Antónia</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Cellular Neuropharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012931"><a href="/gui2/?type=authors&mode=browse&sel=10012931" target="_blank">Lorincz Andrea (<span class="authorship-author-name">Lőrincz Andrea</span> <span class="authorAux-mtmt"> Neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Zoltan (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Foldy Csaba </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="215"><a href="/gui2/?type=authors&mode=browse&sel=215" target="_blank">Szabadics Janos ✉ (<span class="authorship-author-name">Szabadics János</span> <span class="authorAux-mtmt"> Celluláris neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Cellular Neuropharmacology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31411636" target="_blank">Functional specification of CCK plus interneurons by alternative isoforms of Kv4.3 auxiliary subunits</a></div> <div> <span class="journal-title">ELIFE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-084X">2050-084X</a>)</span>: <span class="journal-volume">9</span> <span class="page"> Paper e58515. 26 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.7554/eLife.58515" target="_blank" href="https://doi.org/10.7554/eLife.58515"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000538461700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000538461700001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="8438" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8438"> SE Repozitórium </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="122417" target="_blank" href="https://real.mtak.hu/122417"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85085960644" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85085960644"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="32490811" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32490811&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 12</span> | Independent citation: 9 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;12 | Number of citations with DOI:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31411636&sort=publishedYear,desc&sort=title"> Number of cited publications: 16 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31411636</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="funder"> ERC-AdG(787157), Wellcome Trust(WT, 087497), NAP2.0(KTIA_13_NAP-A-I/5 Funding details: NAP2.0) </div> <div class="lastModified">Last Modified: 2025.08.04. 15:11 Márta Turek (KOKI admin 4) </div> </div></div>