Microenvironmental engineering: An effective strategy for tailoring enzymatic activities

Zhang, Y. ✉; Hess, H.

Angol nyelvű Tudományos Összefoglaló cikk (Folyóiratcikk)
  • SJR Scopus - Chemical Engineering (miscellaneous): Q2
Azonosítók
Rationally, engineering a favorable physicochemical microenvironment for enzymes has recently emerged as an effective strategy to improve their catalytic performance. In this review, we discuss four microenvironmental effects according to the mechanism of action: localizing and excluding reactants and regulators, regulating microenvironmental pH, creating a water-like microenvironment, and increasing the local temperature. These mechanisms are enzyme-independent and can in principle be used in combination to tailor enzyme behaviors, offering new approaches to enabling, enhancing, and regulating enzyme catalysis in diverse applications without the need for genetic engineering. © 2020 Elsevier B.V.
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2021-10-26 21:15