https://m2.mtmt.hu/ hun 2026-03-11 17:51 JournalArticle 31409031 APPROVED true Institute of Enzymology, Research Centre for Natural SciencesBudapest 1117, Hungary Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, United Kingdom MTA-ELTE Protein Modelling Research Group and Laboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös L. UniversityBudapest 1117, Hungary Department of General Zoology, Eötvös Loránd UniversityBudapest 1117, Hungary ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, Eötvös Loránd UniversityBudapest 1117, Hungary Faculty of Medicine and de Duve Institute, Université Catholique de Louvain, Brussels, 1200, Belgium Structural Biology Brussels (SBB), Vrije Universiteit Brussel (VUB), Brussels, 1050, Belgium VIB-VUB Center for Structural Biology (CSB), Vlaams Instituut voor Biotechnologie (VIB), Brussels, 1050, Belgium Gene Editing Research Center, Division of Convergent Biomedical Research, Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141, South Korea Biomedical Translational Research Center, Division of Convergent Biomedical Research, Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141, South Korea Export Date: 22 September 2020 0 false 2026-03-06T10:00:04.098+0000 2025-02-25T21:19:21.445+0000 2020-08-24T11:21:13.494+0000 true 10019782 Csámer Iván /api/admin/10019782 Admin true 10019782 2025-03-26T15:53:55.811+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Murvai, Nikoletta Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14 true true /api/journal/10051562 REVIEWED true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 9 8 1856 1856 2020 Details of the functional mechanisms of intrinsically disordered proteins (IDPs) in living cells is an area not frequently investigated. Here, we dissect the molecular mechanism of action of an IDP in cells by detailed structural analyses based on an in-cell nuclear magnetic resonance experiment. We show that the ID stress protein (IDSP) A. thaliana Early Response to Dehydration (ERD14) is capable of protecting E. coli cells under heat stress. The overexpression of ERD14 increases the viability of E. coli cells from 38.9% to 73.9% following heat stress (50 °C × 15 min). We also provide evidence that the protection is mainly achieved by protecting the proteome of the cells. In-cell NMR experiments performed in E. coli cells show that the protective activity is associated with a largely disordered structural state with conserved, short sequence motifs (K- and H-segments), which transiently sample helical conformations in vitro and engage in partner binding in vivo. Other regions of the protein, such as its S segment and its regions linking and flanking the binding motifs, remain unbound and disordered in the cell. 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10060353"><a href="/gui2/?type=authors&mode=browse&sel=10060353" target="_blank">Murvai Nikoletta (<span class="authorship-author-name">Murvai Nikoletta</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012906"><a href="/gui2/?type=authors&mode=browse&sel=10012906" target="_blank">Kalmar Lajos (<span class="authorship-author-name">Kalmár Lajos</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018778"><a href="/gui2/?type=authors&mode=browse&sel=10018778" target="_blank">Szalaine Agoston Bianka (<span class="authorship-author-name">Szalainé Ágoston Bianka</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018751"><a href="/gui2/?type=authors&mode=browse&sel=10018751" target="_blank">Szabo Beata (<span class="authorship-author-name">Szabó Beáta</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011280"><a href="/gui2/?type=authors&mode=browse&sel=10011280" target="_blank">Tantos Agnes (<span class="authorship-author-name">Tantos Ágnes</span> <span class="authorAux-mtmt"> Molekuláris Biológia, Genetika és Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020323"><a href="/gui2/?type=authors&mode=browse&sel=10020323" target="_blank">Csikos Gyorgy (<span class="authorship-author-name">Csikós György</span> <span class="authorAux-mtmt"> Fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020440"><a href="/gui2/?type=authors&mode=browse&sel=10020440" target="_blank">Micsonai András (<span class="authorship-author-name">Micsonai András</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/MTA-ELTE-NAP B Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014881"><a href="/gui2/?type=authors&mode=browse&sel=10014881" target="_blank">Kardos József (<span class="authorship-author-name">Kardos József</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/MTA-ELTE-NAP B Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vertommen Didier </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nguyen Phuong N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hristozova Nevena </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lang Andras </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kovacs Denes </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000649"><a href="/gui2/?type=authors&mode=browse&sel=10000649" target="_blank">Buday Laszlo (<span class="authorship-author-name">Buday László</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Han Kyou-Hoon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1062306"><a href="/gui2/?type=authors&mode=browse&sel=1062306" target="_blank">Perczel Andras (<span class="authorship-author-name">Perczel András</span> <span class="authorAux-mtmt"> Peptidek és fehérjék szerkezetkutatása</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/MTA-ELTE Fehérjemodellező Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001424"><a href="/gui2/?type=authors&mode=browse&sel=10001424" target="_blank">Tompa Peter (<span class="authorship-author-name">Tompa Péter</span> <span class="authorAux-mtmt"> Enzimológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31409031" target="_blank">Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">9</span> <span class="journal-issue">8</span> <span class="page"> Paper 1856. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span 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class="long-pub-mtid">Közlemény: 31409031</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.02.25. 22:19 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Enzymology, Research Centre for Natural SciencesBudapest 1117, Hungary Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, United Kingdom MTA-ELTE Protein Modelling Research Group and Laboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös L. UniversityBudapest 1117, Hungary ...</pre> </div></div>