The effects of mutant Ras proteins on the cell signalome

Takács, T. [Takács, Tamás (Természettudomány), szerző]; Kudlik, G. [Kudlik, Gyöngyi (molekuláris sejtb...), szerző] Enzimológiai Intézet (TTK); Kurilla, A. [Kurilla, Anita (Biológiai tudományok), szerző]; Szeder, B. [Szeder, Bálint (Molekuláris biológia), szerző] Enzimológiai Intézet (TTK); Buday, L. [Buday, László (Biokémia), szerző] Enzimológiai Intézet (TTK); Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Vas, V. ✉ [Vas, Virág (Őssejt biológia), szerző] Enzimológiai Intézet (TTK)

Angol nyelvű Összefoglaló cikk (Folyóiratcikk) Tudományos
Megjelent: CANCER AND METASTASIS REVIEWS 0167-7659 1573-7233 39 (4) pp. 1051-1065 2020
  • SJR Scopus - Cancer Research: Q1
  • Biokémia és molekuláris biológia
The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation. Ras is a key molecule that controls several tumorigenesis-related processes, and mutations in RAS genes often lead to unbiased intensification of signaling networks that fuel cancer progression. In this article, we review recent studies that describe mutant Ras-regulated signaling routes and their cross-talk. In addition to the two main Ras-driven signaling pathways, i.e., the RAF/MEK/ERK and PI3K/AKT/mTOR pathways, we have also collected emerging data showing the importance of Ras in other signaling pathways, including the RAC/PAK, RalGDS/Ral, and PKC/PLC signaling pathways. Moreover, microRNA-regulated Ras-associated signaling pathways are also discussed to highlight the importance of Ras regulation in cancer. Finally, emerging data show that the signal alterations in specific cell types, such as cancer stem cells, could promote cancer development. Therefore, we also cover the up-to-date findings related to Ras-regulated signal transduction in cancer stem cells. © 2020, The Author(s).
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2024-07-14 18:37