Objective
To compare the effect of two prophylactic euvolemic fluid strategy regimens on the
incidence of cerebral vasospasm and clinical outcomes in patients with aneurysmal
subarachnoid hemorrhage (SAH).
Methods
Ninety-six patients with a basal intravenous intake of 15 mL/kg/day of Ringer’s lactate
solution were included, and an additional 15 to 50 mL/kg/day Ringer’s lactate (RL-group)
or hydroxyethyl starch 130/0.4 solution (HES-group) was administered to maintain the
targeted mean arterial pressure. The primary end point was the occurrence of cerebral
vasospasm during the first 14 days. The secondary end points were case fatality, Barthel’s
index, and Glasgow Outcome Scores (GOS) at 30 days after SAH.
Results
Cerebral vasospasm developed in 42 patients (43.7%), and nine of these events were
severe. The vasospasm rate among the RL- and HES-based groups was 25/48 and 17/48,
respectively. For the secondary endpoint, four patients (4%) died by the end of follow-up
(two in each group). Unfavorable outcome cases were not different in the RL and HES
groups (9 vs. 14, respectively). There was no difference between the Barthel’s scores
at 30 days between the two groups.
Conclusions
Using starches in a prophylactic treatment strategy in aneurysmal SAH in not supported
by the study.
The trial was registered at Clinicaltrials.gov under the number NCT02064075