https://m2.mtmt.hu/ eng 2026-10-23 17:44 JournalArticle 3136945 VALIDATED true 0 2018-10-02T08:54:25.000+0000 false 3136945 2026-10-17T22:32:37.709+0000 2020-06-11T10:27:37.334+0000 2016-11-12T12:35:23.000+0000 true 10028925 Kiss Tivadar /api/admin/10028925 Admin true 10028925 2021-03-24T07:45:27.496+0000 2021-03-24T07:45:27.496+0000 2020-06-10T20:08:56.209+0000 true 10028925 Kiss Tivadar /api/admin/10028925 Admin true 10028925 2020-06-11T10:27:37.356+0000 true 10065829 Laskay Krisztina /api/admin/10065829 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 18 Note, Short, Rapid communications true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/18 Rövid közlemény SubType 103 true 18 true 1 /api/category/1 Category true 1 Jedlinszki, Nikoletta Penetration of lycopsamine from a comfrey ointment through human epidermis true true /api/journal/3883 REVIEWED true false 3883 false 3883 true 0273-2300 1096-0295 Journal FOREIGN 83 1 4 1 4 2017 Abstract Mutagenic and teratogenic pyrrolizidine alkaloids (PAs) have been identified in several plant species. The industrially most important PA-containing plant is Symphytum officinale (common comfrey). The application of its root is restricted in several countries due to its PA content. In medicines, the daily alkaloid quantity and duration of treatment may be limited even in case of topical application. Due to the confirmed good absorption of PAs from the gastrointestinal tract, the prohibition of oral use is justified, however the limitation of external application is not supported by relevant data. Penetration experiments on human skin are not available to be a rational basis for limitation. The aim of our work was to carry out pharmacokinetic studies on the diffusion and penetration of lycopsamine (a main PA of comfrey) from a Symphytum product through a synthetic membrane and human skin. Investigations were carried out on vertical Franz diffusion cell and lycopsamine was quantified by a validated LC-MS method. The amount of lycopsamine diffused through a synthetic membrane varied between 0.11% and 0.72% (within 24 h). On human epidermis, the rate of penetration was lower (0.04–0.22%). 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Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10029087"><a href="/gui2/?type=authors&mode=browse&sel=10029087" target="_blank">Jedlinszki Nikoletta (<span class="authorship-author-name">Jedlinszki Nikoletta</span> <span class="authorAux-mtmt"> analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacognosy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043204"><a href="/gui2/?type=authors&mode=browse&sel=10043204" target="_blank">Balázs Boglárka (<span class="authorship-author-name">Balázs Boglárka</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmaceutical Technology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017479"><a href="/gui2/?type=authors&mode=browse&sel=10017479" target="_blank">Csányi Erzsébet (<span class="authorship-author-name">Csányi Erzsébet</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmaceutical Technology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001143"><a href="/gui2/?type=authors&mode=browse&sel=10001143" target="_blank">Csupor Dezső ✉ (<span class="authorship-author-name">Csupor Dezső</span> <span class="authorAux-mtmt"> Klinikai gyógyszerészet; Fitokémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacognosy; <span title="University of Szeged">SZTE</span>/<span title="Központi egységek">KE</span>/Interdisciplinary Centre for Natural Products</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3136945" target="_blank">Penetration of lycopsamine from a comfrey ointment through human epidermis</a></div> <div> <span class="journal-title">REGULATORY TOXICOLOGY AND PHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0273-2300">0273-2300</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1096-0295">1096-0295</a>)</span>: <span class="journal-volume">83</span> <span class="page"> pp 1-4 </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1016/j.yrtph.2016.11.015" target="_blank" href="https://doi.org/10.1016/j.yrtph.2016.11.015"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="S0273230016303506" target="_blank" href="http://www.sciencedirect.com/science/article/pii/S0273230016303506"> ScienceDirect </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000392166600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000392166600001"> WoS </a> </span> <span class="id identifier oa_CLOSED" title=" Closed "> <a style="color:black" title="100728" target="_blank" href="https://real.mtak.hu/100728"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85006757547" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85006757547"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27840092" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27840092&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_CLOSED" title=" Closed "> <a style="color:blue" title="12744" target="_blank" href="http://publicatio.bibl.u-szeged.hu/12744"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Toxicology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 17</span> | Independent citation: 17 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 13 | Number of citations in Scopus:&nbsp;14 | WoS/Scopus assigned:&nbsp;15 | Number of citations with DOI:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3136945&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3136945</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3136945</span> | Core Citing | <span class="type-subtype">Journal Article ( Note, Short, Rapid communications ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Last Modified: 2020.06.11. 12:27 Krisztina Laskay (SZTE admin5-INAKTÍV) </div> </div></div>