https://m2.mtmt.hu/ hun 2026-06-29 00:57 JournalArticle 31363364 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Fund of Hungary [K 123752, 129593, 2018-1.2.1-NKP-2018-00005] Funding text: This work was financially supported by the National Research, Development and Innovation Fund of Hungary under Grant K 123752, 129593, 2018-1.2.1-NKP-2018-00005 by the Budapesti Muszakies Gazdasagtudomanyi EgyetemBiotechnology Felsooktatasi Intezmenyi Kivalosagi Program grant. 0 false 2026-06-12T06:55:22.595+0000 2022-02-10T09:58:50.596+0000 2020-06-29T07:15:25.333+0000 true 10026330 Kapuy Orsolya /api/author/10026330 Author true 10026330 2024-12-18T10:23:41.408+0000 2021-04-08T13:06:35.368+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Szarka, András Vitamin C and cell death true true /api/journal/10001121 REVIEWED true false 10001121 false 10001121 true 1523-0864 1557-7716 Journal FOREIGN 34 11 831 844 831 14 2021 Persistent oxidative stress is a common feature of cancer cells, giving a specific weapon to selectively eliminate them. Ascorbate in pharmacologic concentration can contribute to the suspended formation of hydroxyl radical via the Fenton reaction, thus it can be an important element of the oxidative stress therapy against cancer cells. Recent Advances: The main components of ascorbate induced cell death are DNA double-strand breaks via the production of hydroxyl radical and ATP depletion due to the activation of PARP1. Presumably, DNA damage can be the primary contributor to the anti-cancer activity of pharmacologic ascorbate, as opposed to the rupture of bioenergetics. The caspase independency of high dose ascorbate induced cell death proposed the possible involvement of several types of cell death such as ferroptosis, necroptosis and autophagy.Ascorbate can target at least two key molecular features of cancer cells as a part of the anti-cancer therapy: the intrinsic or acquired resistance to cell death and the dysregulated metabolism of cancer cells. It seems probable that different concentrations of ascorbate alter the nature of induced cell death. Autophagy and necroptosis may play a role at intermediate concentrations, but caspase independent apoptosis may dominate at higher concentrations. However, ascorbate behaves as an effective inhibitor of ferroptosis that may have crucial importance in its possible clinical application.The elucidation of the details and the links between high dose ascorbate induced cancer selective cell death mechanisms may give us a tool to form and apply synergistic cancer therapies. 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(BME / VBK); Orvosi Vegytani, Molekuláris Biológiai és Patob... (SE / AOK / I) 4 14 2 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 91973164 /api/authorship/91973164 1 0.25 true false true Author 10000174 /api/author/10000174 Szarka András true 10000174 true Szarka András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91973165 /api/authorship/91973165 2 0.25 false false false Author 10026330 /api/author/10026330 Kapuy Orsolya true 10026330 true Kapuy Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91973166 /api/authorship/91973166 3 0.25 false false false Author 10039254 /api/author/10039254 Lőrincz Tamás true 10039254 true Lőrincz Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91973167 /api/authorship/91973167 4 0.25 false true false Author 10011674 /api/author/10011674 Bánhegyi Gábor true 10011674 true Banhegyi Gabor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 17024623 /api/publicationidentifier/17024623 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1089/ars.2019.7897 https://doi.org/10.1089/ars.2019.7897 false true PublicationIdentifier 17133760 /api/publicationidentifier/17133760 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000558373100001 https://www.webofscience.com/wos/woscc/full-record/000558373100001 false true PublicationIdentifier 18631690 /api/publicationidentifier/18631690 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85102994534 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85102994534 true true PublicationIdentifier 17024622 /api/publicationidentifier/17024622 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 32586104 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32586104&dopt=Abstract false true Classification 10575 /api/classification/10575 true true SjrRating 11196119 /api/sjrrating/11196119 42 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true D1 DIRECT true true /api/publication/31363364 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000174"><a href="/gui2/?type=authors&mode=browse&sel=10000174" target="_blank">Szarka András ✉ (<span class="authorship-author-name">Szarka András</span> <span class="authorAux-mtmt"> Biokémia, Biotechnológia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Alkalmazott Biotechnológia és Élelmiszertudományi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026330"><a href="/gui2/?type=authors&mode=browse&sel=10026330" target="_blank">Kapuy Orsolya (<span class="authorship-author-name">Kapuy Orsolya</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039254"><a href="/gui2/?type=authors&mode=browse&sel=10039254" target="_blank">Lőrincz Tamás (<span class="authorship-author-name">Lőrincz Tamás</span> <span class="authorAux-mtmt"> Biomérnökség, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Alkalmazott Biotechnológia és Élelmiszertudományi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011674"><a href="/gui2/?type=authors&mode=browse&sel=10011674" target="_blank">Banhegyi Gabor (<span class="authorship-author-name">Bánhegyi Gábor</span> <span class="authorAux-mtmt"> Biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31363364" target="_blank">Vitamin C and cell death</a></div> <div> <span class="journal-title">ANTIOXIDANTS & REDOX SIGNALING</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1523-0864">1523-0864</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1557-7716">1557-7716</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">11</span> <span class="page"> pp 831-844 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1089/ars.2019.7897" target="_blank" href="https://doi.org/10.1089/ars.2019.7897"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000558373100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000558373100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85102994534" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85102994534"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32586104" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32586104&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 59</span> | Független: 54 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 57 | Scopus jelölt:&nbsp;54 | WoS/Scopus jelölt:&nbsp;59 | DOI jelölt:&nbsp;58 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31363364&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31363364</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (K 123752) Támogató: NKFIH, (129593) Támogató: NKFIH, (HunProtEx 2018-1.2.1-NKP-2018–00005) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2022.02.10. 10:58 Berhidi Anna (SE_KK_Admin5_BA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Research, Development and Innovation Fund of Hungary [K 123752, 129593, 2018-1.2.1-NKP-2018-00005] Funding text: This work was financially supported by the National Research, Development and Innovation Fund of Hungary under Grant K 123752, 129593, 2018-1.2.1-NKP-2018-00005 by the Budapesti Muszakies Gazdasagtudomanyi EgyetemBiotechnology Fel...</pre> </div></div>