A continuous-flow acetylation reaction was developed, applying cheap and safe reagent,
acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes
milder reagent than those used conventionally. The reaction was tested on various
aromatic and aliphatic amines with good conversion. The catalyst showed excellent
reusability and a scale-up was also carried out. Furthermore, a drug substance (paracetamol)
was also synthesized with good conversion and yield.
