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This work was supported by the Medical Scientific Research Foundation of Guangdong Province, China (grant number A2015614).\nDepartment of Hematology and Oncology, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515041, China \n Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515041, China \n Department of Ultrasound, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515041, China \n Export Date: 22 June 2020 \n Correspondence Address: Li, Z.; Department of General Surgery, Second Affiliated Hospital, Shantou University Medical CollegeChina; email: s_zyli4@stu.edu.cn \n Chemicals/CAS: creatinine, 19230-81-0, 60-27-5", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-05-23T06:50:39.954+0000", "lastModified" : "2020-09-16T06:37:26.713+0000", "created" : "2020-06-15T06:54:50.967+0000", "creator" : { "otype" : "Author", "mtid" : 10003400, 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A lower ratio of creatinine to body weight (Cr/BW) is considered the independent risk factor for incident nonalcoholic fatty liver disease (NAFLD). However, the relationship between the Cr/BW ratio and NAFLD among individuals without obesity and dyslipidemia and how this relationship is impacted by age are still ambiguous. Therefore, we explored the effect of the Cr/BW ratio on the incident NAFLD among Chinese without obesity and dyslipidemia of different age groups. Methods. A total of 9756 participants without NAFLD at baseline were included and grouped by the median value (1.32) of the Cr/BW ratio. Then, a further analysis was stratified by age (60 years old). The primary outcome was new-onset NAFLD. Results. After a median follow-up of 2.76 years, 844 (8.7%) participants developed NAFLD. The elderly had a higher person-years incidence rate and cumulative incidence rate than the nonelderly. A high Cr/BW ratio showed a lower cumulative incidence compared to a low Cr/BW ratio for the whole population (P=0.039) and the nonelderly group (P=0.008). After being adjusted for multivariate variables, the lower Cr/BW ratio was the independent risk factor for incident NAFLD in the nonelderly (HR 0.718, 95% CI 0.548-0.942), instead of the elderly. Conclusions. 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