https://m2.mtmt.hu/ eng 2026-04-14 14:16 JournalArticle 3134371 VALIDATED true 0 2018-10-02T08:54:25.000+0000 false 3134371 2026-03-10T10:28:37.045+0000 2024-12-06T17:42:43.369+0000 2016-11-06T04:32:15.000+0000 true 10000041 Szabó András /api/author/10000041 Author true 10000041 2024-09-15T12:31:54.695+0000 2024-12-06T17:42:43.815+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Lanczky, A miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients true true /api/journal/799 REVIEWED true false 799 false 799 true 0167-6806 1573-7217 Journal FOREIGN 160 3 439 446 439 8 2016 PURPOSE: The proper validation of prognostic biomarkers is an important clinical issue in breast cancer research. MicroRNAs (miRNAs) have emerged as a new class of promising breast cancer biomarkers. In the present work, we developed an integrated online bioinformatic tool to validate the prognostic relevance of miRNAs in breast cancer. METHODS: A database was set up by searching the GEO, EGA, TCGA, and PubMed repositories to identify datasets with published miRNA expression and clinical data. Kaplan-Meier survival analysis was performed to validate the prognostic value of a set of 41 previously published survival-associated miRNAs. RESULTS: All together 2178 samples from four independent datasets were integrated into the system including the expression of 1052 distinct human miRNAs. In addition, the web-tool allows for the selection of patients, which can be filtered by receptors status, lymph node involvement, histological grade, and treatments. The complete analysis tool can be accessed online at: www.kmplot.com/mirpower . We used this tool to analyze a large number of deregulated miRNAs associated with breast cancer features and outcome, and confirmed the prognostic value of 26 miRNAs. A significant correlation in three out of four datasets was validated only for miR-29c and miR-101. CONCLUSIONS: In summary, we established an integrated platform capable to mine all available miRNA data to perform a survival analysis for the identification and validation of prognostic miRNA markers in breast cancer. 2016 728279 true true true false true false RESTRICTED 2026-03-10 false true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 649 0 649 637 19 647 635 631 617 649 649 637 637 637 12 0 649 637 649 637 0 5 5 Folyóiratcikk Journal Article 24 645 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 1 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 1 0 1 0 2017 0 5 5 5 5 2018 0 93 92 93 92 2019 0 156 153 156 153 2020 0 138 137 138 137 2021 0 90 87 90 87 2022 0 79 78 79 78 2023 0 44 42 44 42 2024 0 28 28 28 28 2025 0 15 15 15 15 Q1 true 10024232 false false false 2017-11-22T15:30:04.000+0000 2016-11-06T04:34:21.000+0000 II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 5 28 2 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 8511225 /api/authorship/8511225 1 0.143 true false Author 10073052 /api/author/10073052 Lánczky András true true Lanczky A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25159229 true PersonAuthorship 8511226 /api/authorship/8511226 2 0.14285715 false false Author 10047679 /api/author/10047679 Nagy Ádám true 10047679 true Nagy A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25159228 true PersonAuthorship 8511227 /api/authorship/8511227 3 0.14285715 false false Bottai G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25159227 true PersonAuthorship 8511228 /api/authorship/8511228 4 0.14285715 false false Author 10024232 /api/author/10024232 Munkácsy Gyöngyi true 10024232 true Munkacsy G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25159226 true PersonAuthorship 8511229 /api/authorship/8511229 5 0.14285715 false false Author 10000041 /api/author/10000041 Szabó András true 10000041 true Szabo A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25159225 true PersonAuthorship 8511230 /api/authorship/8511230 6 0.143 false false true Santarpia L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25159224 true PersonAuthorship 8511231 /api/authorship/8511231 7 0.143 false true true Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25159223 true PublicationIdentifier 1141987 /api/publicationidentifier/1141987 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1007/s10549-016-4013-7 https://doi.org/10.1007/s10549-016-4013-7 false 1486642 true PublicationIdentifier 1141989 /api/publicationidentifier/1141989 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true CLOSED false NO 46465 http://real.mtak.hu/46465 false 1529624 true PublicationIdentifier 1141990 /api/publicationidentifier/1141990 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true RESTRICTED false IDENTICAL 4049 https://repo.lib.semmelweis.hu/handle/123456789/4049 false 1529625 true PublicationIdentifier 1141985 /api/publicationidentifier/1141985 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000387342800005 https://www.webofscience.com/wos/woscc/full-record/000387342800005 false 1569524 true PublicationIdentifier 1141986 /api/publicationidentifier/1141986 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84991320279 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84991320279 false 1569522 true PublicationIdentifier 1141988 /api/publicationidentifier/1141988 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 27744485 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27744485&dopt=Abstract false 1486643 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12215 /api/classification/12215 true true SjrRating 10918910 /api/sjrrating/10918910 39 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true Q1 DIRECT true true /api/publication/3134371 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073052"><a href="/gui2/?type=authors&mode=browse&sel=10073052" target="_blank">Lanczky A (<span class="authorship-author-name">Lánczky András</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047679"><a href="/gui2/?type=authors&mode=browse&sel=10047679" target="_blank">Nagy A (<span class="authorship-author-name">Nagy Ádám</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bottai G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024232"><a href="/gui2/?type=authors&mode=browse&sel=10024232" target="_blank">Munkacsy G (<span class="authorship-author-name">Munkácsy Gyöngyi</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000041"><a href="/gui2/?type=authors&mode=browse&sel=10000041" target="_blank">Szabo A (<span class="authorship-author-name">Szabó András</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/II. Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Santarpia L ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy B ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/II. Department of Pediatrics; <span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/<span title="Institute of Enzymology">EI</span>/Enzim_417</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3134371" target="_blank">miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients</a></div> <div> <span class="journal-title">BREAST CANCER RESEARCH AND TREATMENT</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0167-6806">0167-6806</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1573-7217">1573-7217</a>)</span>: <span class="journal-volume">160</span> <span class="journal-issue">3</span> <span class="page"> pp 439-446 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s10549-016-4013-7" target="_blank" href="https://doi.org/10.1007/s10549-016-4013-7"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Closed "> <a style="color:black" title="46465" target="_blank" href="http://real.mtak.hu/46465"> REAL </a> </span> <span class="id identifier oa_RESTRICTED" title=" Restricted "> <a style="color:blue" title="4049" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/4049"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000387342800005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000387342800005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84991320279" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84991320279"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27744485" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27744485&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 649</span> | Independent citation: 637 | Self citation: 12 | Unknown citation: 0 | Number of citations in WoS: 631 | Number of citations in Scopus:&nbsp;617 | WoS/Scopus assigned:&nbsp;649 | Number of citations with DOI:&nbsp;635 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3134371&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3134371</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3134371</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2024.12.06. 18:42 Róbert Milánkovics (PTE ÁOK admin 4) </div> </div></div>