Autophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis

https://m2.mtmt.hu/ hun 2026-05-02 20:00 JournalArticle 31337918 VALIDATED true * Megosztott szerzőség 0 false 2025-12-29T17:49:06.356+0000 2025-07-01T19:22:35.662+0000 2020-06-08T21:31:02.765+0000 true 10054118 Szekerczés Tímea /api/author/10054118 Author Szekerczés Tímea (daganatkutatás) true 10054118 2025-07-01T19:22:36.094+0000 2025-07-01T19:22:36.094+0000 2023-09-02T15:38:16.723+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Szekerczés, Tímea Autophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis true true /api/journal/1035680 REVIEWED PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 true false 1035680 false 1035680 true 1219-4956 1532-2807 Journal FOREIGN_AND_HUNGARIAN 26 4 2143 2151 2143 9 2020 Although the role of autophagy has been implicated in several forms of chronic hepatitis, it is still not fully understood. Active autophagy eliminates damaged molecules and organelles (such as mitochondria) by lysosomal degradation. In the present study, we aimed to examine and compare autophagy activity in chronic hepatitis C (CHC) and autoimmune hepatitis (AIH) by detecting the expression of autophagy (LC3 and p62) and mitochondrium-related (TOMM20) proteins, as well as the levels of selected microRNAs (miR-101, -155, -204 and − 224) known to be involved in the regulation of autophagy. In addition, the expression levels were related to pathohistological parameters. Liver biopsy samples, including 45 CHC and 18 AIH cases, were immunohistochemically stained for LC3, p62 and TOMM20 and the expression of miRNAs was determined using real-time PCR. We found elevated LC3 and p62 in AIH samples as compared with CHC ones, indicating an activated autophagy that is impaired in AIH as no degradation of p62 seemed to occur. Moreover, p62 showed strong correlation with necroinflammatory grades in the AIH group. The observed elevated levels of TOMM20 and p62 suggest a less efficient elimination of damaged mitochondria in AIH as opposed to CHC, in which autophagy seems to have a more active function. The level of miR-101 was increased in case of CHC as compared with AIH, however, miR-155, -204 and 224 resulted in no expressional. Furthermore, miR-224 level correlated with steatosis and miR-155 expression with fibrosis stage in CHC. In conclusion, dissimilar autophagic activity was observed in CHC and AIH, suggesting a close association between impaired autophagy and severity of necroinflammation. This impairment may not be regulated by the analyzed miRNAs. Nevertheless, miR-224 and − 155 seem to be associated with CHC progression. Funding 1999867 /api/funding/1999867 (EFOP-3.6.3-VEKOP-16-2017-00009) false true Funding 1999868 /api/funding/1999868 (NVKP-16-1-2016-0004) false true true true 2020 true true true false true false GOLD 2025-12-29 true https://doi.org/10.1007/s12253-020-00799-y 11 0 11 9 2 10 11 9 10 11 11 9 9 9 2 0 11 9 11 9 0 6 6 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 2 1 2 1 2021 0 5 4 5 4 2022 0 0 0 0 0 2023 0 3 3 3 3 2024 0 0 0 0 0 2025 0 0 0 0 0 Q2 false 10015679 false false false 2020-09-06T21:34:00.909+0000 Akadémikus bibliográfia; II. Sz. Belgyógyászati Klinika (SE / AOK / K); II. Sz. Patológiai Intézet (SE / AOK / I); Orvosi Vegytani, Molekuláris Biológiai és Patob... (SE / AOK / I) 9 30 4 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 91798251 /api/authorship/91798251 Szekerczés, Tímea [Szekerczés, Tímea (daganatkutatás), szerző] II. Sz. Patológiai Intézet (SE / AOK / I) 1 0.11111111 true false false Author 10054118 /api/author/10054118 Szekerczés Tímea (daganatkutatás) Szekerczés Tímea true 10054118 true Szekerczés Tímea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 91798252 /api/authorship/91798252 Gógl, Alíz [Gógl, Aliz Ditta (patológia), szerző] II. Sz. Patológiai Intézet (SE / AOK / I) 2 0.11111111 false false false Author 10076554 /api/author/10076554 Gógl Aliz Ditta (patológia) Gógl Aliz Ditta true true Gógl Alíz true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 91798253 /api/authorship/91798253 Illyés, Ildikó [Illyés, Ildikó (patológia), szerző] II. Sz. Patológiai Intézet (SE / AOK / I) 3 0.11111111 false false false Author 10063921 /api/author/10063921 Illyés Ildikó (patológia) Illyés Ildikó true 10063921 true Illyés Ildikó true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 91798254 /api/authorship/91798254 Mandl, József [Mandl, József (biokémia), szerző] Orvosi Vegytani, Molekuláris Biológiai és Patob... (SE / AOK / I) 4 0.11111111 false false false Author 1157922 /api/author/1157922 Mandl József (biokémia) Mandl József true 1157922 true Mandl József true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 91798255 /api/authorship/91798255 Borka, Katalin [Borka, Katalin (patologia), szerző] II. Sz. Patológiai Intézet (SE / AOK / I) 5 0.11111111 false false false Author 10023807 /api/author/10023807 Borka Katalin (patologia) Borka Katalin true 10023807 true Borka Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 91798256 /api/authorship/91798256 Kiss, András [Kiss, András (Pathológia, hepat...), szerző] II. Sz. 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Patológiai Intézet (SE / AOK / I) 8 0.11111111 false true true Author 10020049 /api/author/10020049 Lendvai Gábor András (Molekuláris patológia) Lendvai Gábor András true 10020049 true Lendvai Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 91798259 /api/authorship/91798259 Werling, Klára [Werling, Klára (belgyógyászat, ga...), szerző] II. Sz. 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(2020) PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 26 4 2143-2151<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10054118"><a href="/gui2/?type=authors&mode=browse&sel=10054118" target="_blank">Szekerczés Tímea (<span class="authorship-author-name">Szekerczés Tímea</span> <span class="authorAux-mtmt"> daganatkutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;    <span class="author-name" mtid="10076554"><a href="/gui2/?type=authors&mode=browse&sel=10076554" target="_blank">Gógl Alíz (<span class="authorship-author-name">Gógl Aliz Ditta</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;    <span class="author-name" mtid="10063921"><a href="/gui2/?type=authors&mode=browse&sel=10063921" target="_blank">Illyés Ildikó (<span class="authorship-author-name">Illyés Ildikó</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;    <span class="author-name" mtid="1157922"><a href="/gui2/?type=authors&mode=browse&sel=1157922" target="_blank">Mandl József (<span class="authorship-author-name">Mandl József</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet</span> ;    <span class="author-name" mtid="10023807"><a href="/gui2/?type=authors&mode=browse&sel=10023807" target="_blank">Borka Katalin (<span class="authorship-author-name">Borka Katalin</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;    <span class="author-name" mtid="10000554"><a href="/gui2/?type=authors&mode=browse&sel=10000554" target="_blank">Kiss András (<span class="authorship-author-name">Kiss András</span> <span class="authorAux-mtmt"> Pathológia, hepatocarcinogenesis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;    <span class="author-name" mtid="1323309"><a href="/gui2/?type=authors&mode=browse&sel=1323309" target="_blank">Schaff Zsuzsa (<span class="authorship-author-name">Schaff Zsuzsa</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;    <span class="author-name" mtid="10020049"><a href="/gui2/?type=authors&mode=browse&sel=10020049" target="_blank">Lendvai Gábor<sup>**</sup> ✉ (<span class="authorship-author-name">Lendvai Gábor András</span> <span class="authorAux-mtmt"> Molekuláris patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;    <span class="author-name" mtid="10015679"><a href="/gui2/?type=authors&mode=browse&sel=10015679" target="_blank">Werling Klára (<span class="authorship-author-name">Werling Klára</span> <span class="authorAux-mtmt"> belgyógyászat, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Belgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31337918" target="_blank">Autophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1219-4956">1219-4956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2807">1532-2807</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">4</span> <span class="page"> pp 2143-2151 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s12253-020-00799-y" target="_blank" href="https://doi.org/10.1007/s12253-020-00799-y"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000517690900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000517690900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85081576407" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85081576407"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32124227" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32124227&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)   SJR indikátor: Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine   SJR indikátor: Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research   SJR indikátor: Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology   SJR indikátor: Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 9 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 9 | Scopus jelölt: 10 | WoS/Scopus jelölt: 11 | DOI jelölt: 11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31337918&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31337918</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="special-affiliations"> Speciális affiliáció: Akadémikus bibliográfia </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, (NVKP_16-1-2016-0004) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2025.07.01. 21:22 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>