https://m2.mtmt.hu/ hun 2026-09-20 23:06 JournalArticle 31335197 VALIDATED true T.S. and A.C. contributed equally to the work 0 false 2026-09-03T07:37:40.934+0000 2022-07-13T08:15:05.463+0000 2020-06-05T12:30:42.228+0000 true 10064212 Pásztor-Csizmarik Anita /api/author/10064212 Author true 10064212 2024-06-17T06:44:43.525+0000 2022-07-13T08:15:05.723+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szarvas, Tibor Comprehensive analysis of serum chromogranin A and neuron-specific enolase levels in localized and castration-resistant prostate cancer true true /api/journal/21811 REVIEWED true false 21811 false 21811 true 1464-4096 1464-410X Journal FOREIGN 127 1 44 55 44 12 2021 To assess chromogranin A (CGA) and neuron-specific enolase (NSE) levels and changes in these at different stages of prostatic adenocarcinoma (PCA).Overall, 1095 serum samples from 395 patients, divided into three treatment groups, were analysed; the radical prostatectomy (RP) cohort (n = 157) included patients with clinically localized PCA, while the docetaxel (DOC) and the abiraterone (ABI)/enzalutamide (ENZA) cohorts included 95 and 143 patients, respectively, with metastatic castration-resistant prostate cancer. CGA, NSE and total PSA levels were measured using the KRYPTOR method.Baseline CGA and NSE levels were higher in castration-resistant (DOC and ABI/ENZA cohorts) than in hormone-naïve, clinically localized PCA (P < 0.001). High baseline CGA levels were independently associated with poor overall survival in both the DOC and the ABI/ENZA cohorts, with a stronger association in the ABI/ENZA cohort. In the ABI/ENZA cohort, a > 50% CGA increase at 3 months was associated with poor survival, especially in patients with high baseline CGA levels.The two- to threefold higher neuroendocrine marker levels in castration-resistant compared to hormone-naïve PCA support the presence of neuroendocrine transdifferentiation under androgen deprivation therapy. Our results showed patients with high baseline CGA levels who experienced a further CGA increase during ABI and ENZA treatment had the poorest prognosis. Serum CGA levels could help in tailoring and monitoring therapy in advanced PCA. 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/api/keyword/1507712 true true Keyword 1633748 /api/keyword/1633748 true true SjrRating 11235838 /api/sjrrating/11235838 6 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2748 /api/classificationexternal/2748 true 2748 true D1 DIRECT true true /api/publication/31335197 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor ✉ (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064212"><a href="/gui2/?type=authors&mode=browse&sel=10064212" target="_blank">Csizmarik Anita<sup>*</sup> (<span class="authorship-author-name">Pásztor-Csizmarik Anita</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073300"><a href="/gui2/?type=authors&mode=browse&sel=10073300" target="_blank">Fazekas Tamás (<span class="authorship-author-name">Fazekas Tamás</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055135"><a href="/gui2/?type=authors&mode=browse&sel=10055135" target="_blank">Hüttl András (<span class="authorship-author-name">Hüttl András</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirády Péter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hadaschik Boris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grünwald Viktor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Püllen Lukas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010426"><a href="/gui2/?type=authors&mode=browse&sel=10010426" target="_blank">Jurányi Zsolt (<span class="authorship-author-name">Jurányi Zsolt</span> <span class="authorAux-mtmt"> Onkológiai kutatás, sugárterápia, sugárbiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020433"><a href="/gui2/?type=authors&mode=browse&sel=10020433" target="_blank">Kocsis Zsuzsa (<span class="authorship-author-name">Kocsis Zsuzsa</span> <span class="authorAux-mtmt"> sugárbiológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shariat Shahrokh F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sevcenco Sabina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maj-Hes Agnieszka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kramer Gero </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31335197" target="_blank">Comprehensive analysis of serum chromogranin A and neuron-specific enolase levels in localized and castration-resistant prostate cancer</a></div> <div> <span class="journal-title">BJU INTERNATIONAL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1464-4096">1464-4096</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1464-410X">1464-410X</a>)</span>: <span class="journal-volume">127</span> <span class="journal-issue">1</span> <span class="page"> pp 44-55 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/bju.15086" target="_blank" href="https://doi.org/10.1111/bju.15086"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000532508500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000532508500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85084532821" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85084532821"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32314509" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32314509&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Urology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 33</span> | Független: 29 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 30 | Scopus jelölt:&nbsp;28 | WoS/Scopus jelölt:&nbsp;31 | DOI jelölt:&nbsp;32 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31335197&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31335197</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (NKFIH/FK 12443), (NVKP_16-11-2016-004), (Bolyai János Kutatási Ösztöndíj) Támogató: MTA </div> <div class="lastModified">Utolsó módosítás: 2022.07.13. 10:15 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: T.S. and A.C. contributed equally to the work</pre> </div></div>