https://m2.mtmt.hu/ eng 2026-09-22 11:36 JournalArticle 31334415 VALIDATED true Cited By :21 Export Date: 9 April 2022 CODEN: CVREA 0 false 2026-08-10T20:25:26.525+0000 2026-03-25T09:03:09.382+0000 2020-06-04T19:25:07.033+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author true 10010125 2026-03-27T10:19:46.319+0000 2026-03-27T10:19:46.319+0000 2021-01-28T09:31:27.875+0000 true 10075782 Ferbert Barbara /api/admin/10075782 Admin true 2022-01-07T17:34:49.458+0000 true 10058227 Áts József /api/admin/10058227 Admin true 10058227 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Perrino, C Improving Translational Research in Sex-specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart true true /api/journal/926 REVIEWED true false 926 false 926 true 0008-6363 1755-3245 Journal FOREIGN 117 2 367 385 367 24 2021 Ischemic heart disease (IHD) is a complex disorder and a leading cause of death and morbidity in both men and women. Sex however affects several aspects of IHD, including pathophysiology, incidence, clinical presentation, diagnosis as well as treatment and outcome. Several diseases or risk factors frequently associated with IHD can modify cellular signalling cascades, thus affecting ischemia/reperfusion injury as well as responses to cardioprotective interventions. Importantly, the prevalence and impact of risk factors and several comorbidities differ between males and females, and their effects on IHD development and prognosis might differ according to sex. The cellular and molecular mechanisms underlying these differences are still poorly understood, and their identification might have important translational implications in the prediction or prevention of risk of IHD in men and women. Despite this, most experimental studies on IHD are still undertaken in animal models in the absence of risk factors and comorbidities, and assessment of potential sex-specific differences are largely missing. This ESC WG Position Paper will discuss: a) the importance of sex as a biological variable in cardiovascular research, b) major biological mechanisms underlying sex-related differences relevant to IHD risk factors and comorbidities, c) prospects and pitfalls of preclinical models to investigate these associations, and finally d) will provide recommendations to guide future research. Although gender differences also affect IHD risk in the clinical setting, they will not be discussed in detail here. 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/api/authorship/91767485 22 0.04 false false false Van Laake L W true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91767486 /api/authorship/91767486 23 0.04 false false false Van Linthout S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91767487 /api/authorship/91767487 24 0.04 false true false Schulz R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91767488 /api/authorship/91767488 25 0.04 false true false Ytrehus K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16960350 /api/publicationidentifier/16960350 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1093/cvr/cvaa155 https://doi.org/10.1093/cvr/cvaa155 false true PublicationIdentifier 18534108 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 32484892 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32484892&dopt=Abstract false true Keyword 15274 /api/keyword/15274 true 15274 true Keyword 1037339 /api/keyword/1037339 true 1037339 true Keyword 1060923 /api/keyword/1060923 true 1060923 true Keyword 1110024 /api/keyword/1110024 true 1110024 true Keyword 1204845 /api/keyword/1204845 true 1204845 true Keyword 1607846 /api/keyword/1607846 true true SjrRating 11227899 /api/sjrrating/11227899 16 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/31334415 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Perrino C ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy P<sup>*</sup> (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bøtker H E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brundel B J J M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Collins P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Davidson S M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >den Ruijter H M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Engel F B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gerdts E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Girao H </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gyöngyösi M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hausenloy D J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lecour S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Madonna R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Marber M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Murphy E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pesce M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Regitz-Zagrosek V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sluijter J P G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Steffens S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gollmann-Tepeköylü C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Van Laake L W </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Van Linthout S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz R<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ytrehus K </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31334415" target="_blank">Improving Translational Research in Sex-specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection : Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart.</a></div> <div> <span class="journal-title">CARDIOVASCULAR RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0008-6363">0008-6363</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1755-3245">1755-3245</a>)</span>: <span class="journal-volume">117</span> <span class="journal-issue">2</span> <span class="page"> pp 367-385 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1093/cvr/cvaa155" target="_blank" href="https://doi.org/10.1093/cvr/cvaa155"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000613754100017" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000613754100017"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85100358979" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85100358979"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32484892" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32484892&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physiology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 72</span> | Independent citation: 49 | Self citation: 23 | Unknown citation: 0 | Number of citations in WoS: 68 | Number of citations in Scopus:&nbsp;65 | WoS/Scopus assigned:&nbsp;72 | Number of citations with DOI:&nbsp;71 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31334415&sort=publishedYear,desc&sort=title"> Number of cited publications: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31334415</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (OTKA KH 125570) Funder: NRDIO, National Heart Program(NVKP-16-1-2016-0017) Funder: NRDIO, (Higher Education Institutional Excellence Programme of the Ministry of Human Capacities of Hungary, within the framework of the Therapeutic Development thematic programme of the Semmelweis University), COST </div> <div class="lastModified">Last Modified: 2026.03.25. 10:03 Anna Sághi-Keszthelyi (SE_KK_Admin5_SKA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :21 Export Date: 9 April 2022 CODEN: CVREA</pre> </div></div>