https://m2.mtmt.hu/ hun 2026-09-23 12:58 JournalArticle 3132593 VALIDATED true Megjegyzés-26360759 Group Author: EXCEL Trial Investigators 0 2017-03-17T09:38:02.000+0000 false 3132593 2026-09-17T10:48:57.566+0000 2023-09-19T16:55:44.092+0000 2016-11-01T13:18:05.000+0000 true 10002691 Merkely Béla Péter /api/author/10002691 Author true 10002691 2023-09-19T16:55:44.642+0000 2023-09-19T16:55:44.642+0000 2022-11-24T21:10:17.947+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Stone, GW Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 375 23 2223 2235 2223 13 2016 Background Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. Methods We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients). Anatomic complexity was assessed at the sites and defined by a Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score of 32 or lower (the SYNTAX score reflects a comprehensive angiographic assessment of the coronary vasculature, with 0 as the lowest score and higher scores [no upper limit] indicating more complex coronary anatomy). The primary end point was the rate of a composite of death from any cause, stroke, or myocardial infarction at 3 years, and the trial was powered for noninferiority testing of the primary end point (noninferiority margin, 4.2 percentage points). Major secondary end points included the rate of a composite of death from any cause, stroke, or myocardial infarction at 30 days and the rate of a composite of death, stroke, myocardial infarction, or ischemia-driven revascularization at 3 years. Event rates were based on Kaplan-Meier estimates in time-to-first-event analyses. Results At 3 years, a primary end-point event had occurred in 15.4% of the patients in the PCI group and in 14.7% of the patients in the CABG group (difference, 0.7 percentage points; upper 97.5% confidence limit, 4.0 percentage points; P=0.02 for noninferiority; hazard ratio, 1.00; 95% confidence interval, 0.79 to 1.26; P=0.98 for superiority). The secondary end-point event of death, stroke, or myocardial infarction at 30 days occurred in 4.9% of the patients in the PCI group and in 7.9% in the CABG group (P<0.001 for noninferiority, P=0.008 for superiority). The secondary end-point event of death, stroke, myocardial infarction, or ischemia-driven revascularization at 3 years occurred in 23.1% of the patients in the PCI group and in 19.1% in the CABG group (P=0.01 for noninferiority, P=0.10 for superiority). Conclusions In patients with left main coronary artery disease and low or intermediate SYNTAX scores by site assessment, PCI with everolimus-eluting stents was noninferior to CABG with respect to the rate of the composite end point of death, stroke, or myocardial infarction at 3 years. (Funded by Abbott Vascular; EXCEL ClinicalTrials.gov number, NCT01205776 .). 2016 (Merkely Béla Péter (Kardiológia); 2016.11.01. 14:17:41) true true true false true false GREEN 2026-09-17 true http://publicatio.bibl.u-szeged.hu/24155 942 7 940 728 12 938 905 858 817 928 928 716 716 730 212 0 942 730 940 728 0 1 1 Folyóiratcikk Journal Article 24 936 Könyvrészlet Chapter in Book 25 4 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 2 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 11 10 11 10 2017 0 124 112 124 112 2018 0 170 143 170 143 2019 0 127 99 127 99 2020 0 133 98 133 98 2021 0 107 74 107 74 2022 0 81 56 81 56 2023 0 67 44 67 44 2024 0 53 39 53 39 2025 0 42 35 42 35 2026 0 27 20 27 20 D1 true false false false 2017-03-17T09:38:02.000+0000 2016-11-01T13:21:49.000+0000 II. sz. Belgyógyászati Klinika és Kardiológiai ... 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/api/classification/12215 true true SjrRating 10946602 /api/sjrrating/10946602 3 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/3132593 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Stone GW ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely B (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007590"><a href="/gui2/?type=authors&mode=browse&sel=10007590" target="_blank">Horkay F (<span class="authorship-author-name">Horkay Ferenc</span> <span class="authorAux-mtmt"> Szívbetegségek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Szívsebészeti Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062147"><a href="/gui2/?type=authors&mode=browse&sel=10062147" target="_blank">Ungi I (<span class="authorship-author-name">Ungi Imre</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Kardiológiai Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032784"><a href="/gui2/?type=authors&mode=browse&sel=10032784" target="_blank">Bogats G (<span class="authorship-author-name">Bogáts Gábor</span> <span class="authorAux-mtmt"> Orvostudomány, szívsebész</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Kardiológiai Központ</span> ;&nbsp;&nbsp;&nbsp; et al. (33) </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" >Gerrit-Anne van Es </span> ;&nbsp;&nbsp;&nbsp; et al. (343) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">EXCEL Trial Investigators</span> </div> <div><a target="_blank" href="/api/publication/3132593?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3132593" target="_blank">Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">375</span> <span class="journal-issue">23</span> <span class="page"> pp 2223-2235 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa1610227" target="_blank" href="https://doi.org/10.1056/NEJMoa1610227"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000389310000005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000389310000005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85003545668" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85003545668"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27797291" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27797291&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="24155" target="_blank" href="http://publicatio.bibl.u-szeged.hu/24155"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 942</span> | Független: 730 | Függő: 212 | Nem jelölt: 0 | WoS jelölt: 858 | Scopus jelölt:&nbsp;817 | WoS/Scopus jelölt:&nbsp;928 | DOI jelölt:&nbsp;905 (Nem nyilvános:&nbsp;7) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3132593&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3132593</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3132593</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2023.09.19. 18:55 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-26360759 Group Author: EXCEL Trial Investigators</pre> </div></div>