Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009)
Támogató: EFOP-VEKOP
Szakterületek:
Farmakológia és gyógyszerészet
Gyógyszerismeret
Metaanalízis
Effective and selective oral rinses are required in the daily medical and dental practice.
Currently used mouthwashes have substantial side effects.Our aim was to evaluate the
efficacy of chlorine dioxide-containing mouthwashes in comparison with other previously
established mouth rinses in healthy adults using oral hygiene indices.This work was
registered in PROSPERO (CRD42018099059) and carried out using multiple databases and
reported according to the PRISMA statement. The following search terms were used "chlorine
dioxide" AND "oral", only randomised controlled trials (RCTs) were included. The primary
outcome was the alteration of the plaque index (PI), while the secondary outcomes
were the gingival index (GI) and bacterial counts. For the risk of bias assessment,
the Cochrane Risk of Bias Tool was used. Statistical analysis for data heterogeneity
was performed by Q-value and I2 -tests.364 articles were found in the databases. After
the selection process, only five RCTs were eligible for meta-analysis. Data heterogeneity
was low. There were no statistical differences in effectiveness between chlorine dioxide
and the other effective mouth rinses in PI (0.720±0.119 vs 0.745±0.131; 95%; confidence
intervals (CIs): 0.487-0.952 vs 0.489- 1.001, respectively) and GI (0.712±0.130 vs
0.745±0.131; 95% CIs: 0.457-0.967 vs 0.489- 1.001, respectively) and also in bacterial
counts.Chlorine dioxide reduces both plaque and gingival indices and bacterial counts
in the oral cavity similar to other routinely used oral rinses, however, the evidence
supporting this is very limited. Therefore, further large scale RCTs are needed to
decrease the risk of bias.
