{ "labelLang" : "hun", "responseDate" : "2024-03-28 18:26", "content" : { "otype" : "JournalArticle", "mtid" : 31311164, "status" : "APPROVED", "published" : true, "comment" : "Women's Health and HIV Research Group, Department of Obstetrics and Gynecology, University of KwaZulu-Natal, South Africa \n Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa \n Export Date: 12 May 2020 \n Correspondence Address: Moodley, M.; Department of Optics and Imaging, Doris Duke Medical Research Institute, Nelson R Mandela School of MedicineSouth Africa; email: 214514757@stu.ukzn.ac.za \n Funding details: Inyuvesi Yakwazulu-Natali, UKZN \n Funding text 1: The authors acknowledge the UKZN College of Health Sciences and the National Research Foundation of South Africa for financial support. \n Funding text 2: The authors would like to thank Mrs D Margolis (Optics and Imaging, UKZN) for her guidance with the laboratory work. Additionally, the authors would like to express their sincere gratitude to the College of Health Sciences (UKZN) and the National Research Foundation (NRF) for their funding contributions.\nWomen's Health and HIV Research Group, Department of Obstetrics and Gynecology, University of KwaZulu-Natal, South Africa \n Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa \n Cited By :1 \n Export Date: 26 June 2020 \n Correspondence Address: Moodley, M.; Department of Optics and Imaging, Doris Duke Medical Research Institute, Nelson R Mandela School of MedicineSouth Africa; email: 214514757@stu.ukzn.ac.za \n Funding details: Inyuvesi Yakwazulu-Natali, UKZN \n Funding text 1: The authors acknowledge the UKZN College of Health Sciences and the National Research Foundation of South Africa for financial support. \n Funding text 2: The authors would like to thank Mrs D Margolis (Optics and Imaging, UKZN) for her guidance with the laboratory work. Additionally, the authors would like to express their sincere gratitude to the College of Health Sciences (UKZN) and the National Research Foundation (NRF) for their funding contributions.\nWomen's Health and HIV Research Group, Department of Obstetrics and Gynecology, University of KwaZulu-Natal, South Africa \n Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa \n Cited By :1 \n Export Date: 8 September 2020 \n Correspondence Address: Moodley, M.; Department of Optics and Imaging, Doris Duke Medical Research Institute, Nelson R Mandela School of MedicineSouth Africa; email: 214514757@stu.ukzn.ac.za \n Chemicals/CAS: histone, 9062-68-4; Biomarkers; Histones \n Funding details: Inyuvesi Yakwazulu-Natali, UKZN \n Funding text 1: The authors acknowledge the UKZN College of Health Sciences and the National Research Foundation of South Africa for financial support. \n Funding text 2: The authors would like to thank Mrs D Margolis (Optics and Imaging, UKZN) for her guidance with the laboratory work. Additionally, the authors would like to express their sincere gratitude to the College of Health Sciences (UKZN) and the National Research Foundation (NRF) for their funding contributions.\nWomen's Health and HIV Research Group, Department of Obstetrics and Gynecology, University of KwaZulu-Natal, South Africa \n Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa \n Cited By :1 \n Export Date: 2 February 2021 \n Correspondence Address: Moodley, M.; Department of Optics and Imaging, South Africa; email: 214514757@stu.ukzn.ac.za \n Chemicals/CAS: histone, 9062-68-4; Biomarkers; Histones \n Funding details: Inyuvesi Yakwazulu-Natali, UKZN \n Funding text 1: The authors acknowledge the UKZN College of Health Sciences and the National Research Foundation of South Africa for financial support. \n Funding text 2: The authors would like to thank Mrs D Margolis (Optics and Imaging, UKZN) for her guidance with the laboratory work. Additionally, the authors would like to express their sincere gratitude to the College of Health Sciences (UKZN) and the National Research Foundation (NRF) for their funding contributions.\nWomen's Health and HIV Research Group, Department of Obstetrics and Gynecology, University of KwaZulu-Natal, South Africa \n Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa \n Cited By :1 \n Export Date: 22 February 2021 \n Correspondence Address: Moodley, M.; Department of Optics and Imaging, South Africa; email: 214514757@stu.ukzn.ac.za \n Chemicals/CAS: histone, 9062-68-4; Biomarkers; Histones \n Funding details: Inyuvesi Yakwazulu-Natali, UKZN \n Funding text 1: The authors acknowledge the UKZN College of Health Sciences and the National Research Foundation of South Africa for financial support. \n Funding text 2: The authors would like to thank Mrs D Margolis (Optics and Imaging, UKZN) for her guidance with the laboratory work. Additionally, the authors would like to express their sincere gratitude to the College of Health Sciences (UKZN) and the National Research Foundation (NRF) for their funding contributions.\nWomen's Health and HIV Research Group, Department of Obstetrics and Gynecology, University of KwaZulu-Natal, South Africa \n Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa \n Cited By :1 \n Export Date: 3 June 2021 \n Correspondence Address: Moodley, M.; Department of Optics and Imaging, South Africa; email: 214514757@stu.ukzn.ac.za \n Funding details: Inyuvesi Yakwazulu-Natali, UKZN \n Funding text 1: The authors would like to thank Mrs D Margolis (Optics and Imaging, UKZN) for her guidance with the laboratory work. Additionally, the authors would like to express their sincere gratitude to the College of Health Sciences (UKZN) and the National Research Foundation (NRF) for their funding contributions. \n Funding text 2: The authors acknowledge the UKZN College of Health Sciences and the National Research Foundation of South Africa for financial support.", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-02-12T15:07:10.182+0000", "lastModified" : "2021-01-11T13:37:57.175+0000", "created" : "2020-05-12T13:51:47.408+0000", "creator" : { "otype" : "Author", "mtid" : 10011643, "link" : "/api/author/10011643", "label" : "Mócsai Attila (Élettan, sejtbiológia)", "familyName" : "Mócsai", "givenName" : "Attila", "published" : true, "oldId" : 10011643, "snippet" : true }, "validated" : "2020-12-06T01:45:00.862+0000", "validator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, 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"74", "firstPageOrInternalIdForSort" : "69", "pageLength" : 6, "publishedYear" : 2020, "abstractText" : "Objectives: To immuno-localize histone H2A expression as a marker of neutrophil extracellular traps (NETs) in the placenta; and to quantify and compare the percentage H2A immune-expression as a marker of NETs in the placental intervillous space according to: pregnancy type, HIV status and across the study population. Study design: The participants to the study were a pregnant South African population group of African ancestry (n = 60) stratified as normotensive (N) (n = 30) or pre-eclamptic (PE) (n = 30) and further subdivided as HIV infected (HIV+) (n = 15) or HIV naïve (HIV−) (n = 15). Following informed consent placental tissue samples were obtained at the time of delivery. Immunohistochemistry using the anti-histone 2A (H2A) antibody as a biomarker of NETs, and morphometric image analysis was used to immuno-localize and quantify placental H2A immuno-expression respectively in the placental inter-villous space. Statistical analysis was performed using Graph Pad Prism software (Version 5). Main outcome measures: To determine if HIV neutralizes the elevated NETs in PE. Results: NETs were localized within the inter-villous space surrounding the exchange villi and conducting villi of placental tissue. Based on HIV status, a significant elevation in H2A immuno-expression was observed in the HIV+ compared to the HIV− group (p = 0.0008) and in the pre-eclampsia HIV− compared to the normotensive HIV− group (p = 0.0008). However, a significant decline in H2A immuno-expression was observed in the PEHIV+ group compared to the NHIV+ group (p = 0.0072). Conclusions: Both PE and HIV elevate placental NETs; however, they synergistically downregulate NETs expression. 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