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Ltd., Shanghai, China \n Export Date: 29 April 2020 \n Correspondence Address: Wang, Z.; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural UniversityChina; email: wangzh@cau.edu.cn \n Funding details: Special Fund for Agro-scientific Research in the Public Interest, 20140304–07 \n Funding details: 2107YFD0500506 \n Funding text 1: This research was funded by the National Key Research and Development Plan (No. 2107YFD0500506) and the National Special Fund for Agro-scientific Research in the Public Interest (20140304–07). The funders had no role in the study design, analysis or writing of this article.", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-07-29T06:51:57.705+0000", "lastModified" : "2020-08-25T23:46:38.121+0000", "created" : "2020-04-29T12:50:31.749+0000", "creator" : { "otype" : "Admin", "mtid" : 10056781, "link" : "/api/admin/10056781", "label" : "Katalin Bikádi (Állatorvostud. 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"internalId" : "18", "firstPageOrInternalIdForSort" : "18", "publishedYear" : 2020, "abstractText" : "Background: The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis (NE) due to Clostridium perfringens. In the present study, we investigated the effects of dietary supplementation with a blend of encapsulated essential oils and organic acids (BLJ) on growth performance and gut health using a coinfection model of NE in broiler chickens. Methods: Two hundred and eighty-eight one-day-old male Arbor Acres broiler chicks were randomly assigned using a 2 × 2 factorial design into two groups fed either 0 or 500 mg/kg dietary BLJ and co-challenged (or not challenged for the control) with Eimeria spp./C. perfringens. Results: Infected birds fed the BLJ-supplemented diet exhibited an improved feed conversion ratio throughout the trial (P < 0.01), a higher villus height and villus height/crypt depth ratio, and reduced intestinal C. perfringens counts, liver C. perfringens carriage, gut lesion scores and serum fluorescein isothiocyanate dextran (FITC-D) concentrations at 7 d post-infection compared with those of birds without BLJ supplementation (P < 0.05). NE-infected birds fed BLJ exhibited significantly upregulated claudin-1 and IGF-2 mRNA levels (P < 0.05), increased A20 mRNA expression and significantly downregulated TRAF-6, TNFSF15 and TOLLIP mRNA levels in the jejunum at 7 d post-infection compared with those in birds without BLJ supplementation (P < 0.05). Compared with the uninfected and untreated birds, the uninfected birds fed BLJ displayed increased relative abundances of Lactobacillus and Coprococcus but reduced Rikenellaceae levels. Compared with the unsupplemented NE-challenged birds, infected birds fed BLJ showed an increased relative abundance of Unclassified_Lachnospiraceae and a significantly decreased relative abundance of Erysipelotrichaceae. Conclusion: BLJ supplementation improved growth performance and gut health in NE-infected broiler chickens by strengthening the intestinal barrier function, positively modulating the gut microbiota community and differentially regulating intestinal immune responses. Our results also suggested that adding BLJ effectively controlled NE infections after experimental Eimeria and Clostridium perfringens coinfection. © 2020 The Author(s).", "keywords" : [ { "otype" : "Keyword", "mtid" : 1032341, "link" : "/api/keyword/1032341", "label" : "Clostridium perfringens", "published" : true, "oldId" : 1032341, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1557237, "link" : "/api/keyword/1557237", "label" : "Broiler chickens", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1595164, "link" : "/api/keyword/1595164", "label" : "gut health", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2008839, "link" : "/api/keyword/2008839", "label" : "Essential oils and organic acids", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2020, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2022-07-29", "oaFree" : false, "oaLink" : "http://www.jasbsci.com/", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10739527, "link" : "/api/sjrrating/10739527", "label" : "sjr:D1 (2020) Scopus - Animal Science and Zoology JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY 1674-9782 2049-1891", "listPos" : 9, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1103, "link" : "/api/classificationexternal/1103", "label" : "Scopus - Animal Science and Zoology", "published" : true, "oldId" : 1103, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "referenceList" : "Timbermont, L., Haesebrouck, F., Ducatelle, R., Van Immerseel, F., Timbermont, L., Haesebrouck, F., Necrotic enteritis in broilers: An updated review on the pathogenesis (2011) Avian Pathol, 40, pp. 341-347. , 10.1080/03079457.2011.590967 1:STN:280:DC%2BC3MjjsFOhtQ%3D%3D 21812711 ;\n Van Immerseel, F., Rood, J.I., Moore, R.J., Titball, R.W., Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens (2009) Trends in Microbiology, 17 (1), pp. 32-36. , 1:CAS:528:DC%2BD1MXns12nsw%3D%3D ;\n Brenes, A., Roura, E., Essential oils in poultry nutrition: Main effects and modes of action (2010) Anim Feed Sci Technol, 158, pp. 1-14. , 10.1016/j.anifeedsci.2010.03.007 1:CAS:528:DC%2BC3cXmtFantrs%3D ;\n Henri, I., Bassolé, N., Hrj, Essential oils in combination and their antimicrobial properties (2012) Molecules, 17, pp. 3989-4006. , 10.3390/molecules17043989 1:CAS:528:DC%2BC38Xlsl2rtLk%3D ;\n Gopi, M., Karthik, K., Manjunathachar, H.V., Kesavan, M., Dashprakash, M., Balaraju, B.L., Review article essential oils as a feed additive in poultry nutrition (2014) Adv Anim Vet Sci, 2, pp. 1-7 ;\n Devi, K.P., Nisha, S.A., Sakthivel, R., Pandian, S.K., Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane (2010) Journal of Ethnopharmacology, 130 (1), pp. 107-115. , 1:CAS:528:DC%2BC3cXnvVOks7Y%3D ;\n Stevanović, Z., Bošnjak-Neumüller, J., Pajić-Lijaković, I., Raj, J., Vasiljević, M., Essential Oils as Feed Additives - Future Perspectives (2018) Molecules, 23 (7), p. 1717 ;\n Swamy, M.K., Akhtar, M.S., Sinniah, U.R., Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review (2016) Evidence-Based Complementary and Alternative Medicine, 2016, pp. 1-21 ;\n Du, E., Gan, L., Li, Z., Wang, W., Liu, D., Guo, Y., In vitro antibacterial activity of thymol and carvacrol and their effects on broiler chickens challenged with Clostridium perfringens (2015) J Anim Sci Biotechnol., 6, pp. 1-12. , https://doi.org/10.1186/s40104-015-0055-7 ;\n Jang, I.S., Ko, Y.H., Kang, S.Y., Lee, C.Y., Effect of a commercial essential oil on growth performance, digestive enzyme activity and intestinal microflora population in broiler chickens (2007) Anim Feed Sci Technol, 134, pp. 304-315. , 10.1016/j.anifeedsci.2006.06.009 1:CAS:528:DC%2BD2sXjslGktLw%3D ;\n Chowdhury, S., Mandal, G.P., Patra, A.K., Kumar, P., Samanta, I., Pradhan, S., Different essential oils in diets of broiler chickens: 2. Gut microbes and morphology, immune response, and some blood profile and antioxidant enzymes (2018) Anim Feed Sci Technol, 236, pp. 39-47. , 10.1016/j.anifeedsci.2017.12.003 1:CAS:528:DC%2BC2sXhvFOht77P ;\n Chowdhury, S., Mandal, G.P., Patra, A.K., Different essential oils in diets of chickens: 1. Growth performance, nutrient utilisation, nitrogen excretion, carcass traits and chemical composition of meat (2018) Anim Feed Sci Technol, 236, pp. 86-97. , 10.1016/j.anifeedsci.2017.12.002 1:CAS:528:DC%2BC2sXhvFOntLvO ;\n Pirgozliev, V., Bravo, D., Mirza, M.W., Rose, S.P., Growth performance and endogenous losses of broilers fed wheat-based diets with and without essential oils and xylanase supplementation (2015) Poult Sci, 94, pp. 1227-1232. , 10.3382/ps/peu017 1:CAS:528:DC%2BC2sXhvFCgtbrN 25650434 ;\n Mitsch, P., Zitterl-Eglseer, K., Köhler, B., Gabler, C., Losa, R., Zimpernik, I., The effect of two different blends of essential oil components on the proliferation of Clostridium perfringens in the intestines of broiler chickens (2004) Poultry Science, 83 (4), pp. 669-675. , 1:CAS:528:DC%2BD2cXjs1Wns7Y%3D ;\n Liu, S., Song, M., Yun, W., Lee, J., Lee, C., Kwak, W., Effects of oral administration of different dosages of carvacrol essential oils on intestinal barrier function in broilers (2018) J Anim Physiol Anim Nutr, 102, pp. 1257-1265. , 10.1111/jpn.12944 1:CAS:528:DC%2BC1cXhs12isL7I ;\n Peng, Q.Y., Li, J.D., Li, Z., Duan, Z.Y., Wu, Y.P., Effects of dietary supplementation with oregano essential oil on growth performance, carcass traits and jejunal morphology in broiler chickens (2016) Anim Feed Sci Technol, 214, pp. 148-153. , 10.1016/j.anifeedsci.2016.02.010 1:CAS:528:DC%2BC28XjtFChu7k%3D ;\n Zeng, Z., Zhang, S., Wang, H., Piao, X., Essential oil and aromatic plants as feed additives in non-ruminant nutrition: A review (2015) Journal of Animal Science and Biotechnology, 6 (1), p. 7 ;\n Sun, Q., Liu, D., Guo, S., Chen, Y., Guo, Y., Effects of dietary essential oil and enzyme supplementation on growth performance and gut health of broilers challenged by Clostridium perfringens (2015) Animal Feed Science and Technology, 207, pp. 234-244. , 1:CAS:528:DC%2BC2MXhtFWgtrfM ;\n Hashemipour, H., Khaksar, V., Rubio, L.A., Veldkamp, T., Van Krimpen, M.M., Effect of feed supplementation with a thymol plus carvacrol mixture, in combination or not with an NSP-degrading enzyme, on productive and physiological parameters of broilers fed on wheat-based diets (2016) Animal Feed Science and Technology, 211, pp. 117-131. , 1:CAS:528:DC%2BC2MXhslanurbO ;\n Bravo, D., Pirgozliev, V., Rose, S.P., A mixture of carvacrol, cinnamaldehyde, and capsicum oleoresin improves energy utilization and growth performance of broiler chickens fed maize-based diet (2014) J Anim Sci, 92, pp. 1531-1536. , 10.2527/jas.2013-6244 1:STN:280:DC%2BC2cvitVyjtg%3D%3D 24496847 ;\n Khodambashi Emami, N., Samie, A., Rahmani, H.R., Ruiz-Feria, C.A., The effect of peppermint essential oil and fructooligosaccharides, as alternatives to virginiamycin, on growth performance, digestibility, gut morphology and immune response of male broilers (2012) Animal Feed Science and Technology, 175 (1-2), pp. 57-64. , 1:CAS:528:DC%2BC38XmtFGhu7o%3D ;\n Kazempour, F., Jahanian, R., Effects of different organic acids on performance, ileal microflora, and phosphorus utilization in laying hens fed diet deficient in non-phytate phosphorus (2017) Animal Feed Science and Technology, 223, pp. 110-118. , 1:CAS:528:DC%2BC2sXitlWgtQ%3D%3D ;\n Li, Y., Fu, X., Ma, X., Geng, S., Jiang, X., Huang, Q., Intestinal microbiome-Metabolome responses to essential oils in piglets (2018) Front Microbiol, 9, pp. 1-13. , 10.3389/fmicb.2018.01988 ;\n Diaz Carrasco, J.M., Redondo, L.M., Redondo, E.A., Dominguez, J.E., Chacana, A.P., Fernandez Miyakawa, M.E., Use of Plant Extracts as an Effective Manner to ControlClostridium perfringensInduced Necrotic Enteritis in Poultry (2016) BioMed Research International, 2016, pp. 1-15 ;\n Paul, S.K., Halder, G., Mondal, M.K., Samanta, G., Effect of organic acid salt on the performance and gut health of broiler chicken (2007) J Poult Sci, 44, pp. 389-395. , 1:CAS:528:DC%2BD2sXhtlOit7rI ;\n De Los Santos, F.S., Donoghue, A.M., Venkitanarayanan, K., Reyes-Herrera, I., Metcalf, J.H., Dirain, M.L., Aguiar, V.F., Donoghue, D.J., Therapeutic Supplementation of Caprylic Acid in Feed Reduces Campylobacter jejuni Colonization in Broiler Chicks (2008) Applied and Environmental Microbiology, 74 (14), pp. 4564-4566 ;\n Skrivanova, E., Marounek, M., Dlouha, G., Kanka, J., Susceptibility of Clostridium perfringens to C2-C18 fatty acids (2005) Letters in Applied Microbiology, 41 (1), pp. 77-81. , 1:CAS:528:DC%2BD28XhvFGhtbc%3D ;\n Song, B., Li, H., Wu, Y., Zhen, W., Wang, Z., Xia, Z., Effect of microencapsulated sodium butyrate dietary supplementation on growth performance and intestinal barrier function of broiler chickens infected with necrotic enteritis (2017) Anim Feed Sci Technol, 232, pp. 6-15. , 10.1016/j.anifeedsci.2017.07.009 1:CAS:528:DC%2BC2sXht1ylt7fP ;\n Geier, M.S., Mikkelsen, L.L., Torok, V.A., Allison, G.E., Olnood, C.G., Boulianne, M., Comparison of alternatives to in-feed antimicrobials for the prevention of clinical necrotic enteritis (2010) J Appl Microbiol, 109, pp. 1329-1338. , 10.1111/j.1365-2672.2010.04758.x 1:CAS:528:DC%2BC3cXhtlejs77I 20497278 ;\n Diao, H., Gao, Z., Yu, B., Zheng, P., He, J., Yu, J., Effects of benzoic acid (VevoVitall ®) on the performance and jejunal digestive physiology in young pigs (2016) J Anim Sci Biotechnol, 7, pp. 1-7. , 10.1186/s40104-016-0091-y 1:CAS:528:DC%2BC2sXnvVSmu7c%3D 26779340 4714447 ;\n Kluge, H., Broz, J., Eder, K., Effect of benzoic acid on growth performance, nutrient digestibility, nitrogen balance, gastrointestinal microflora and parameters of microbial metabolism in piglets (2006) Journal of Animal Physiology and Animal Nutrition, 90 (7-8), pp. 316-324. , 1:CAS:528:DC%2BD28XosFequrg%3D ;\n Zentek, J., Ferrara, F., Vahjen, W., Van Kessel, A.G., Nutritional and physiological role of medium-chain triglycerides and medium-chain fatty acids in piglets (2011) Anim Health Res Rev, 12, pp. 83-93. , 10.1017/S1466252311000089 1:STN:280:DC%2BC3MngvFKgtA%3D%3D 21676342 ;\n Omonijo, F.A., Ni, L., Gong, J., Wang, Q., Lahaye, L., Yang, C., Essential oils as alternatives to antibiotics in swine production (2018) Anim Nutr, 4, pp. 126-136. , 10.1016/j.aninu.2017.09.001 30140752 ;\n Clark, P., Jerry White. A Great and Monstrous Thing: London in the Eighteenth Century (2014) The American Historical Review, 119 (2), pp. 599-600 ;\n Yang, X., Xin, H., Yang, C., Yang, X., Impact of essential oils and organic acids on the growth performance, digestive functions and immunity of broiler chickens (2018) Anim Nutr, 4, pp. 388-393. , 10.1016/j.aninu.2018.04.005 30564758 6284223 ;\n Isabel, B., Santos, Y., Effects of dietary organic acids and essential oils on growth performance and carcass characteristics of broiler chickens (2009) J Appl Poult Res, 18, pp. 472-476. , 10.3382/japr.2008-00096 1:CAS:528:DC%2BD1MXhtFGru7jF ;\n Wu, Y., Shao, Y., Song, B., Zhen, W., Wang, Z., Guo, Y., Effects of Bacillus coagulans supplementation on the growth performance and gut health of broiler chickens with Clostridium perfringens-induced necrotic enteritis (2018) J Anim Sci Biotechnol., 9, pp. 1-14. , https://doi.org/10.1186/s40104-017-0220-2 ;\n Shao, Y., Guo, Y., Wang, Z., β-1,3/1,6-Glucan alleviated intestinal mucosal barrier impairment of broiler chickens challenged with Salmonella enterica serovar Typhimurium (2013) Poult Sci, 92, pp. 1764-1773. , 1:CAS:528:DC%2BC3sXhtVGlsLvK ;\n Mfa, B., Merino-Guzman, R., Latorre, J.D., Mahaffey, B.D., Yang, Y., Teague, K.D., Optimizing fluorescein isothiocyanate dextran measurement as a biomarker in a 24-h feed restriction model to induce gut permeability in broiler chickens (2017) Front Vet Sci., 4, pp. 1-6. , https://doi.org/10.3389/fvets.2017.00056 ;\n Livak, K.J., Schmittgen, T.D., Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-ΔΔCT Method (2001) Methods, 25 (4), pp. 402-408. , 1:CAS:528:DC%2BD38XhtFelt7s%3D ;\n Magoc, T., Salzberg, S.L., FLASH: Fast length adjustment of short reads to improve genome assemblies (2011) Bioinformatics, 27 (21), pp. 2957-2963. , 1:CAS:528:DC%2BC3MXhtlGkur7M ;\n Caporaso, J.G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F.D., Costello, E.K., QIIME allows analysis of high-throughput community sequencing data (2011) Nat Methods, 7, pp. 335-336. , 10.1038/nmeth.f.303.QIIME ;\n Lozupone, C.A., Hamady, M., Kelley, S.T., Knight, R., Quantitative and Qualitative Diversity Measures Lead to Different Insights into Factors That Structure Microbial Communities (2007) Applied and Environmental Microbiology, 73 (5), pp. 1576-1585. , 1:CAS:528:DC%2BD2sXjsVSktr0%3D ;\n Ramette, A., Multivariate analyses in microbial ecology (2007) FEMS Microbiol Ecol, 62, pp. 142-160. , 10.1111/j.1574-6941.2007.00375.x 1:CAS:528:DC%2BD2sXht1yns73J 17892477 17892477 ;\n Zaura, E., Keijser, B.J.F., Huse, S.M., Crielaard, W., Defining the healthy \"core microbiome\" of oral microbial communities (2009) BMC Microbiol, 9, pp. 1-12. , 10.1186/1471-2180-9-259 1:CAS:528:DC%2BD1MXhsF2gu7bM ;\n Chen, Y., Yang, F., Lu, H., Wang, B., Chen, Y., Lei, D., Wang, Y., Li, L., Characterization of fecal microbial communities in patients with liver cirrhosis (2011) Hepatology, 54 (2), pp. 562-572 ;\n Liu, Y., Yang, X., Xin, H., Chen, S., Yang, C., Duan, Y., Effects of a protected inclusion of organic acids and essential oils as antibiotic growth promoter alternative on growth performance, intestinal morphology and gut microflora in broilers (2017) Anim Sci J, 88, pp. 1414-1424. , 10.1111/asj.12782 1:CAS:528:DC%2BC2sXhsV2jsr3J 28317217 ;\n Yang, X., Liu, Y., Yan, F., Yang, C., Yang, X., Effects of encapsulated organic acids and essential oils on intestinal barrier, microbial count, and bacterial metabolites in broiler chickens (2019) Poult Sci, pp. 1-8. , 10.3382/ps/pez031 ;\n Giannenas, I., Papaneophytou, C.P., Tsalie, E., Pappas, I., Triantafillou, E., Tontis, D., Kontopidis, G.A., Dietary Supplementation of Benzoic Acid and Essential Oil Compounds Affects Buffering Capacity of the Feeds, Performance of Turkey Poults and Their Antioxidant Status, pH in the Digestive Tract, Intestinal Microbiota and Morphology (2014) Asian-Australasian Journal of Animal Sciences, 27 (2), pp. 225-236. , 1:CAS:528:DC%2BC2cXns12ksb8%3D ;\n Fascina, V.B., Sartori, J.R., Gonzales, E., Carvalho, F.B.D., Souza, I.M.G.P.D., Polycarpo, G.D.V., Stradiotti, A.C., Pelícia, V.C., Phytogenic additives and organic acids in broiler chicken diets (2012) Revista Brasileira de Zootecnia, 41 (10), pp. 2189-2197 ;\n Zhai, H., Liu, H., Wang, S., Wu, J., Kluenter, A.M., Potential of essential oils for poultry and pigs (2018) Anim Nutr, 4, pp. 179-186. , 10.1016/j.aninu.2018.01.005 30140757 6103468 ;\n Celi, P., Cowieson, A.J., Fru-Nji, F., Steinert, R.E., Kluenter, A., Verlhac, V., Gastrointestinal functionality in animal nutrition and health: New opportunities for sustainable animal production (2017) Anim Feed Sci Technol, 234, pp. 88-100. , 10.1016/j.anifeedsci.2017.09.012 ;\n Jerzsele, A., Szeker, K., Csizinszky, R., Gere, E., Jakab, C., Mallo, J.J., Galfi, P., Efficacy of protected sodium butyrate, a protected blend of essential oils, their combination, and Bacillus amyloliquefaciens spore suspension against artificially induced necrotic enteritis in broilers (2012) Poultry Science, 91 (4), pp. 837-843. , 1:CAS:528:DC%2BC38Xls1aqsrc%3D ;\n Olajuyigbe, O.O., Coopoosamy, R.M., Influence of First-Line Antibiotics on the Antibacterial Activities of Acetone Stem Bark Extract ofAcacia mearnsiiDe Wild. Against Drug-Resistant Bacterial Isolates (2014) Evidence-Based Complementary and Alternative Medicine, 2014, pp. 1-11 ;\n Peterson, L.W., Artis, D., Intestinal epithelial cells: Regulators of barrier function and immune homeostasis (2014) Nat Rev Immunol, 14, pp. 141-153. , 10.1038/nri3608 1:CAS:528:DC%2BC2cXivFyju7s%3D 24566914 ;\n Du, E., Wang, W., Gan, L., Li, Z., Guo, S., Guo, Y., Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens (2016) J Anim Sci Biotechnol., 7, pp. 1-10. , https://doi.org/10.1186/s40104-016-0079-7 ;\n Suzuki, T., Regulation of intestinal epithelial permeability by tight junctions (2013) Cell Mol Life Sci, 70, pp. 631-659. , 10.1007/s00018-012-1070-x 1:CAS:528:DC%2BC3sXhsFektr8%3D 22782113 ;\n Kim, Y.S., Ho, S.B., Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress (2010) Current Gastroenterology Reports, 12 (5), pp. 319-330 ;\n Bauer, H., Zweimueller-Mayer, J., Steinbacher, P., Lametschwandtner, A., Bauer, H.C., The Dual Role of Zonula Occludens (ZO) Proteins (2010) Journal of Biomedicine and Biotechnology, 2010, pp. 1-11 ;\n Nighot, M., Al-Sadi, R., Guo, S., Rawat, M., Nighot, P., Watterson, M.D., Ma, T.Y., Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression (2017) The American Journal of Pathology, 187 (12), pp. 2698-2710. , 1:CAS:528:DC%2BC2sXhvVCjsbbM ;\n Broom, L.J., Kogut, M.H., Deciphering desirable immune responses from disease models with resistant and susceptible chickens (2019) Poult Sci, 98, pp. 1634-1642. , 10.3382/ps/pey535 30534980 ;\n Edelblum, K.L., Turner, J.R., The tight junction in inflammatory disease: Communication breakdown (2009) Curr Opin Pharmacol, 9, pp. 715-720. , 10.1016/j.coph.2009.06.022.The 1:CAS:528:DC%2BD1MXhsVGqs7rF 19632896 2788114 ;\n Jeong, E., Lee, J.Y., Intrinsic and extrinsic regulation of innate immune receptors (2011) Yonsei Med J, 52, pp. 379-392. , 10.3349/ymj.2011.52.3.379 1:CAS:528:DC%2BC3MXovVKjtLk%3D 21488180 3101043 ;\n Segain, J.-P., Butyrate inhibits inflammatory responses through NFkappa B inhibition: Implications for Crohn's disease (2000) Gut, 47 (3), pp. 397-403. , 1:CAS:528:DC%2BD3cXmsFOhtb8%3D ;\n Sommer, F., Bäckhed, F., The gut microbiota - Masters of host development and physiology (2013) Nature Reviews Microbiology, 11 (4), pp. 227-238. , 1:CAS:528:DC%2BC3sXivFOrtbY%3D ;\n Hiippala, K., Jouhten, H., Ronkainen, A., Hartikainen, A., Kainulainen, V., Jalanka, J., Satokari, R., The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation (2018) Nutrients, 10 (8), p. 988 ;\n Bortoluzzi, C., Pedroso, A.A., Mallo, J.J., Puyalto, M., Kim, W.K., Applegate, T.J., Sodium butyrate improved performance while modulating the cecal microbiota and regulating the expression of intestinal immune-related genes of broiler chickens (2017) Poult Sci, 96, pp. 3981-3993. , 10.3382/ps/pex218 1:CAS:528:DC%2BC1cXitl2ku73N 29050425 ;\n Meehan, C.J., Beiko, R.G., A Phylogenomic View of Ecological Specialization in the Lachnospiraceae, a Family of Digestive Tract-Associated Bacteria (2014) Genome Biology and Evolution, 6 (3), pp. 703-713. , 1:CAS:528:DC%2BC2MXjtlWrtbo%3D ;\n Reeves, A.E., Koenigsknecht, M.J., Bergin, I.L., Young, V.B., Suppression of Clostridium difficile in the Gastrointestinal Tracts of Germfree Mice Inoculated with a Murine Isolate from the Family Lachnospiraceae (2012) Infection and Immunity, 80 (11), pp. 3786-3794. , 1:CAS:528:DC%2BC38XhsFKmtrfF ;\n Torok, V.A., Allison, G.E., Percy, N.J., Ophel-Keller, K., Hughes, R.J., Influence of Antimicrobial Feed Additives on Broiler Commensal Posthatch Gut Microbiota Development and Performance (2011) Applied and Environmental Microbiology, 77 (10), pp. 3380-3390. , 1:CAS:528:DC%2BC3MXns1SltL0%3D ;\n Diao, H., Zheng, P., Yu, B., He, J., Mao, X., Yu, J., Chen, D., Effects of Benzoic Acid and Thymol on Growth Performance and Gut Characteristics of Weaned Piglets (2015) Asian-Australasian Journal of Animal Sciences, 28 (6), pp. 827-839. , 1:CAS:528:DC%2BC2MXhsFKmtr7K ;\n Nava, G.M., Attene-Ramos, M.S., Gaskins, H.R., Richards, J.D., Molecular analysis of microbial community structure in the chicken ileum following organic acid supplementation (2009) Vet Microbiol, 137, pp. 345-353. , 10.1016/j.vetmic.2009.01.037 1:CAS:528:DC%2BD1MXmtFeltr8%3D 19269115 ;\n Tsai, Y., Cheng, P., Pan, T., The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits (2012) Appl Microbiol Biotechnol, 96, pp. 853-862. , 10.1007/s00253-012-4407-3 1:CAS:528:DC%2BC38XhsFGqsbzN 23001058 ;\n Hui, S.T., Parks, B.W., Org, E., Norheim, F., Che, N., Pan, C., The genetic architecture of NAFLD among inbred strains of mice (2015) ELife, 4, pp. 1-28. , https://doi.org/10.7554/eLife.05607 ;\n He, B., Hoang, T.K., Tian, X., Taylor, C.M., Blanchard, E., Luo, M., Lactobacillus reuteri reduces the severity of experimental autoimmune encephalomyelitis in mice by modulating gut microbiota (2019) Front Immunol., 10, pp. 385-397. , https://doi.org/10.3389/fimmu.2019.00385 ;\n Timbermont, L., Lanckriet, A., Dewulf, J., Nollet, N., Schwarzer, K., Haesebrouck, F., Ducatelle, R., Van Immerseel, F., Control ofClostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils (2010) Avian Pathology, 39 (2), pp. 117-121. , 1:CAS:528:DC%2BC3cXkslKru78%3D", "hasCitationDuplums" : false, "userChangeableUntil" : "2020-04-28T12:57:16.979+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 6, "ownerInstituteCount" : 23, "directInstituteCount" : 0, "authorCount" : 8, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/31294964", "label" : "Pham V.H. et al. 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