https://m2.mtmt.hu/ eng 2026-09-21 20:52 JournalArticle 31287764 VALIDATED true EID: 2-s2.0-85081991389 Export Date: 21 September 2026 0 false 2026-09-21T07:36:45.566+0000 2026-09-21T07:34:16.524+0000 2020-04-22T15:20:04.073+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Márta Turek (KOKI admin 4) true 2026-09-21T07:34:16.382+0000 2024-04-09T08:15:10.894+0000 true 10075667 Szabó Emese /api/admin/10075667 Admin Emese Szabó (Wigner admin5) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Ujfalussy, B.B. true true /api/journal/10015678 REVIEWED NATURE COMMUNICATIONS 2041-1723 true false 10015678 false 10015678 true 2041-1723 Journal FOREIGN 11 1 1413 1413 14 2020 Clustering of functionally similar synapses in dendrites is thought to affect neuronal input-output transformation by triggering local nonlinearities. However, neither the in vivo impact of synaptic clusters on somatic membrane potential (sVm), nor the rules of cluster formation are elucidated. We develop a computational approach to measure the effect of functional synaptic clusters on sVm response of biophysical model CA1 and L2/3 pyramidal neurons to in vivo-like inputs. We demonstrate that small synaptic clusters appearing with random connectivity do not influence sVm. With structured connectivity, ~10–20 synapses/cluster are optimal for clustering-based tuning via state-dependent mechanisms, but larger selectivity is achieved by 2-fold potentiation of the same synapses. We further show that without nonlinear amplification of the effect of random clusters, action potential-based, global plasticity rules cannot generate functional clustering. Our results suggest that clusters likely form via local synaptic interactions, and have to be moderately large to impact sVm responses. © 2020, The Author(s). Funding 1994997 /api/funding/1994997 Nemzeti Kutatási Fejlesztési és Innovációs Hivatal,(NKFIH, PD-125386) false true Funding 1994998 /api/funding/1994998 Howard Hughes Medical Institute(HHMI 55008740) false true true true 2020 true true true false true false GOLD 2026-09-21 true https://doi.org/10.1038/s41467-020-15147-6 33 0 33 31 3 33 33 31 31 33 33 31 31 31 2 0 33 31 33 31 0 10 10 Folyóiratcikk Journal Article 24 33 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 2 1 2 1 2021 0 5 5 5 5 2022 0 3 3 3 3 2023 0 6 5 6 5 2024 0 6 6 6 6 2025 0 8 8 8 8 2026 0 3 3 3 3 D1 A nemzetközi false 10017153,146 false false false 2020-07-16T14:01:19.902+0000 Lendület Idegi Jelátvitel Kutatócsoport (KOKI / CHO) 2 23 1 2 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 91483207 /api/authorship/91483207 Ujfalussy, B.B. ✉ [Ujfalussy, Balázs Benedek (Idegtudományok), author] Laboratory of Neuronal Signaling (IEM / DCNN) 1 0.5 true false true Author 10017153 /api/author/10017153 Balázs Benedek Ujfalussy (Idegtudományok) Ujfalussy Balázs Benedek true 10017153 true Ujfalussy B.B. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 91483208 /api/authorship/91483208 Makara, J.K. [Makara, Judit (Neurobiológia), author] Laboratory of Neuronal Signaling (IEM / DCNN) 2 0.5 false true false Author 146 /api/author/146 Judit Makara (Neurobiológia) Makara Judit true 146 true Makara J.K. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 16854086 /api/publicationidentifier/16854086 DOI: 10.1038/s41467-020-15147-6 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41467-020-15147-6 https://doi.org/10.1038/s41467-020-15147-6 false true PublicationIdentifier 16934094 /api/publicationidentifier/16934094 WoS: 000521328300014 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000521328300014 https://www.webofscience.com/wos/woscc/full-record/000521328300014 false true PublicationIdentifier 18534064 /api/publicationidentifier/18534064 REAL: 122442 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 122442 https://real.mtak.hu/122442 false true PublicationIdentifier 16854085 /api/publicationidentifier/16854085 Scopus: 85081991389 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85081991389 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85081991389 false true PublicationIdentifier 17002179 /api/publicationidentifier/17002179 PubMed: 32179739 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 32179739 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32179739&dopt=Abstract false true Keyword 135 /api/keyword/135 MODEL true 135 true Keyword 633 /api/keyword/633 MEMBRANE true 633 true Keyword 1699 /api/keyword/1699 ARTICLE true 1699 true Keyword 5079 /api/keyword/5079 nonhuman true 5079 true Keyword 5086 /api/keyword/5086 animal model true 5086 true Keyword 5087 /api/keyword/5087 animal experiment true 5087 true Keyword 5088 /api/keyword/5088 animal cell true 5088 true Keyword 6813 /api/keyword/6813 Nervous System true 6813 true Keyword 6834 /api/keyword/6834 nerve potential true 6834 true Keyword 6918 /api/keyword/6918 synapse true 6918 true Keyword 14998 /api/keyword/14998 in vivo study true 14998 true Keyword 21418 /api/keyword/21418 Cluster Analysis true 21418 true Keyword 1010083 /api/keyword/1010083 pyramidal nerve cell true 1010083 true Keyword 1013356 /api/keyword/1013356 Physical model true 1013356 true Keyword 1086337 /api/keyword/1086337 hippocampal CA1 region true 1086337 true MtaRating 11551153 /api/mtarating/11551153 IX. Committee on Regional Studies:A nemzetközi NATURE COMMUNICATIONS 2041-1723 RatingType 10010 /api/ratingtype/10010 IX. Committee on Regional Studies RegTB Institute 14100 /api/institute/14100 Committee on Regional Studies HASSELIX RTB [1901-] 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi false true SjrRating 10751794 /api/sjrrating/10751794 sjr:D1 (2020) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) NATURE COMMUNICATIONS 2041-1723 11 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true D1 DIRECT true true Reference 2623409 /api/reference/2623409 1. Larkum, M.E., Nevian, T., Synaptic clustering by dendritic signalling mechanisms (2008) Curr. Opin. 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(2020) NATURE COMMUNICATIONS 2041-1723 11 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017153"><a href="/gui2/?type=authors&mode=browse&sel=10017153" target="_blank">Ujfalussy B.B. ✉ (<span class="authorship-author-name">Ujfalussy Balázs Benedek</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Neuronal Signaling</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="146"><a href="/gui2/?type=authors&mode=browse&sel=146" target="_blank">Makara J.K. (<span class="authorship-author-name">Makara Judit</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Neuronal Signaling</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31287764" target="_blank">Impact of functional synapse clusters on neuronal response selectivity</a></div> <div> <span class="journal-title">NATURE COMMUNICATIONS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2041-1723">2041-1723</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">1</span> <span class="page"> Paper 1413. 14 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41467-020-15147-6" target="_blank" href="https://doi.org/10.1038/s41467-020-15147-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000521328300014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000521328300014"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="122442" target="_blank" href="https://real.mtak.hu/122442"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85081991389" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85081991389"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32179739" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32179739&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physics and Astronomy (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 33</span> | Independent citation: 31 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 31 | Number of citations in Scopus:&nbsp;31 | WoS/Scopus assigned:&nbsp;33 | Number of citations with DOI:&nbsp;33 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31287764&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31287764</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> Nemzeti Kutatási Fejlesztési és Innovációs Hivatal,(NKFIH, PD-125386), Howard Hughes Medical Institute(HHMI 55008740) </div> <div class="lastModified">Last Modified: 2026.09.21. 09:34 Ilona Verle (Wigner admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: EID: 2-s2.0-85081991389 Export Date: 21 September 2026</pre> </div></div>