Background: The considerable increase in the incidence of Candida infection in recent
times has prompted the use of numerous antifungal agents, which has resulted in the
development of resistance towards various antifungal agents. With rising Candida infections,
the need for design and development of novel antifungal agents is in great demand.
However, new therapeutic approaches are very essential in preventing the mortality
rate and improving the patient outcome in those suffering from Candida infections.
Objective: The present review objective is to describe the burden, types of Candidiasis,
mechanism of action of antifungal agents and its resistance and the current novel
approaches used to combat candidiasis. Methods: We have collected and analyzed 135
different peer-reviewed literature studies pertinent to candidiasis. In this review,
we have compiled the major findings from these studies. Results and Conclusion: The
review describes the concerns related to candidiasis, its current treatment strategy,
resistance mechanisms and imminent ways to tackle the problem. The review explored
that natural plant extracts and essential oils could act as sources of newer therapeutic
agents, however, the focus was on novel strategies, such as combinational therapy,
new antibodies, utilization of photodynamic therapy and adaptive transfer primed immune
cells with emphasis on the development of effective vaccination.