https://m2.mtmt.hu/ eng 2026-05-30 23:07 JournalArticle 31281646 VALIDATED true Heart and Vascular Center, Semmelweis University, Városmajor u. 68, Budapest, H-1122, Hungary Hungarian Marfan Foundation, Városmajor u. 68, Budapest, H-1122, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Ülloi út 26, Budapest, H-1085, Hungary MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, Budapest, H-1122, Hungary Cited By :6 Export Date: 9 October 2021 Correspondence Address: Ágg, B.; Heart and Vascular Center, Városmajor u. 68, Hungary; email: agg.bence@med.semmelweis-univ.hu Manufacturers: Philips 0 false 2026-05-19T22:09:23.526+0000 2025-01-08T13:00:48.238+0000 2020-04-17T18:54:11.085+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author true 10010125 2026-03-19T11:03:24.088+0000 2026-03-19T11:03:24.088+0000 2022-11-24T18:59:50.677+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ágg, Bence Increased visceral arterial tortuosity in Marfan syndrome true true /api/journal/10007208 REVIEWED true false 10007208 false 10007208 true 1750-1172 1750-1172 Journal FOREIGN 15 1 91 91 10 2020 Clinical evidence suggests that the currently recommended approach to estimate the risk of aortic dissection in Marfan syndrome (MFS) is not reliable enough. Therefore, we investigated the possible role of visceral arterial tortuosity in the risk stratification.Splenic and renal arteries of 37 MFS patients and 74 age and gender matched control subjects were segmented using CT angiography imaging. To measure tortuosity, distance metric (DM), sum of angles metric (SOAM), inflection count metric (ICM), and the ratio of ICM and SOAM (ICM/SOAM) were calculated. DM of the splenic, right and left renal artery was significantly higher in MFS patients than in controls (2.44 [1.92-2.80] vs. 1.75 [1.57-2.18] p < 0.001; 1.16 [1.10-1.28] vs. 1.11 [1.07-1.15] p = 0.011; 1.40 [1.29-1.70] vs. 1.13 [1.09-1.23] p < 0.001, respectively). A similar tendency for ICM and an opposite tendency for SOAM were observed. ICM/SOAM was significantly higher in the MFS group compared to controls in case of all three arteries (73.35 [62.26-93.63] vs. 50.91 [43.19-65.62] p < 0.001; 26.52 [20.69-30.24] vs. 19.95 [16.47-22.95] p < 0.001; 22.81 [18.64-30.96] vs. 18.38 [15.29-21.46] p < 0.001, respectively). MFS patients who underwent aortic root replacement had increased right and left renal DM and ICM/SOAM compared to MFS patients without surgery.To our knowledge this is the first demonstration of increased arterial tortuosity in MFS on visceral arteries. Visceral arterial tortuosity, dominated by curves of lower frequency but higher amplitude according to the observed opposite tendency between the DM and SOAM metrics, could be a possible new predictor of serious manifestations of MFS. Funding 2048583 /api/funding/2048583 false true Funding 2048584 /api/funding/2048584 false true Funding 2048585 /api/funding/2048585 false true Funding 2048586 /api/funding/2048586 false true true 2020 true true true false true false GOLD 2026-05-20 true https://doi.org/10.1186/s13023-020-01369-w 21 0 21 14 7 19 20 18 18 20 20 13 13 14 7 0 21 14 21 14 0 6 6 Folyóiratcikk Journal Article 24 19 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 1 0 1 0 2021 0 8 5 8 5 2022 0 2 2 2 2 2023 0 2 1 2 1 2024 0 2 2 2 2 2025 0 3 2 3 2 2026 0 3 2 3 2 Q1 false 10057401 false false false 2020-07-16T19:01:29.255+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); MTA-SE Lendület Kardiovaszkuláris Képalkotó Kut... (SE / AOK / K / OKK); Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 12 56 4 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 91447036 /api/authorship/91447036 1 0.083 true false true Author 10057401 /api/author/10057401 Ágg Bence true 10057401 true Ágg Bence true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447037 /api/authorship/91447037 2 0.083333336 false false false Author 10045643 /api/author/10045643 Szilveszter Bálint true 10045643 true Szilveszter Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447038 /api/authorship/91447038 3 0.083333336 false false false Author 10075216 /api/author/10075216 Daradics Noémi true true Daradics Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447039 /api/authorship/91447039 4 0.083333336 false false false Author 10048080 /api/author/10048080 Benke Kálmán true 10048080 true Benke Kálmán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447040 /api/authorship/91447040 5 0.083333336 false false false Author 10074675 /api/author/10074675 Stengl Roland true true Stengl Roland true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447041 /api/authorship/91447041 6 0.083333336 false false false Author 10050627 /api/author/10050627 Kolossváry Márton József true 10050627 true Kolossváry Márton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447042 /api/authorship/91447042 7 0.083333336 false false false Author 10026455 /api/author/10026455 Pólos Miklós true 10026455 true Pólos Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447043 /api/authorship/91447043 8 0.083333336 false false false Author 10013969 /api/author/10013969 Radovits Tamás true 10013969 true Radovits Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447044 /api/authorship/91447044 9 0.083333336 false false false Author 10010125 /api/author/10010125 Ferdinandy Péter true 10010125 true Ferdinandy Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447045 /api/authorship/91447045 10 0.083 false false false Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Béla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447046 /api/authorship/91447046 11 0.083333336 false false false Author 10019530 /api/author/10019530 Maurovich-Horvat Pál true 10019530 true Maurovich-Horvat Pál true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91447047 /api/authorship/91447047 12 0.083333336 false true false Author 10026449 /api/author/10026449 Szabolcs Zoltán true 10026449 true Szabolcs Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16839070 /api/publicationidentifier/16839070 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s13023-020-01369-w https://doi.org/10.1186/s13023-020-01369-w false true PublicationIdentifier 16919880 /api/publicationidentifier/16919880 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000528759400001 https://www.webofscience.com/wos/woscc/full-record/000528759400001 true true PublicationIdentifier 16919872 /api/publicationidentifier/16919872 PlainSource 3 /api/publicationsource/3 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RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q1 DIRECT true true /api/publication/31281646 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10057401"><a href="/gui2/?type=authors&mode=browse&sel=10057401" target="_blank">Ágg Bence ✉ (<span class="authorship-author-name">Ágg Bence</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045643"><a href="/gui2/?type=authors&mode=browse&sel=10045643" target="_blank">Szilveszter Bálint (<span class="authorship-author-name">Szilveszter Bálint</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/MTA-SE Cardiovascular Imaging Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075216"><a href="/gui2/?type=authors&mode=browse&sel=10075216" target="_blank">Daradics Noémi (<span class="authorship-author-name">Daradics Noémi</span> <span class="authorAux-mtmt"> Sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048080"><a href="/gui2/?type=authors&mode=browse&sel=10048080" target="_blank">Benke Kálmán (<span class="authorship-author-name">Benke Kálmán</span> <span class="authorAux-mtmt"> Szívsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074675"><a href="/gui2/?type=authors&mode=browse&sel=10074675" target="_blank">Stengl Roland (<span class="authorship-author-name">Stengl Roland</span> <span class="authorAux-mtmt"> Szív és érbetegségek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050627"><a href="/gui2/?type=authors&mode=browse&sel=10050627" target="_blank">Kolossváry Márton (<span class="authorship-author-name">Kolossváry Márton József</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/MTA-SE Cardiovascular Imaging Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026455"><a href="/gui2/?type=authors&mode=browse&sel=10026455" target="_blank">Pólos Miklós (<span class="authorship-author-name">Pólos Miklós</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013969"><a href="/gui2/?type=authors&mode=browse&sel=10013969" target="_blank">Radovits Tamás (<span class="authorship-author-name">Radovits Tamás</span> <span class="authorAux-mtmt"> kardiológia, érgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019530"><a href="/gui2/?type=authors&mode=browse&sel=10019530" target="_blank">Maurovich-Horvat Pál (<span class="authorship-author-name">Maurovich-Horvat Pál</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/MTA-SE Cardiovascular Imaging Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026449"><a href="/gui2/?type=authors&mode=browse&sel=10026449" target="_blank">Szabolcs Zoltán (<span class="authorship-author-name">Szabolcs Zoltán</span> <span class="authorAux-mtmt"> Szívsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31281646" target="_blank">Increased visceral arterial tortuosity in Marfan syndrome</a></div> <div> <span class="journal-title">ORPHANET JOURNAL OF RARE DISEASES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1750-1172">1750-1172</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1750-1172">1750-1172</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">1</span> <span class="page"> Paper 91. 10 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s13023-020-01369-w" target="_blank" href="https://doi.org/10.1186/s13023-020-01369-w"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000528759400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000528759400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85083411186" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85083411186"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32293489" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32293489&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Genetics (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 21</span> | Independent citation: 14 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 18 | Number of citations in Scopus:&nbsp;18 | WoS/Scopus assigned:&nbsp;20 | Number of citations with DOI:&nbsp;20 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31281646&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31281646</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> National Heart Program(NVKP-16-1-2016-0017) Funder: NRDIO, (UNKP-17-3-I-SE-31), (UNKP-18-3-I-SE-69), (UNKP-19-3-I-SE-54) </div> <div class="lastModified">Last Modified: 2025.01.08. 14:00 Zóra Kondor (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Heart and Vascular Center, Semmelweis University, Városmajor u. 68, Budapest, H-1122, Hungary Hungarian Marfan Foundation, Városmajor u. 68, Budapest, H-1122, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Ülloi út 26, Budapest, H-1085, Hungary MTA-SE Cardiovascular Imaging Research Group, He...</pre> </div></div>