https://m2.mtmt.hu/ hun 2026-09-21 18:30 JournalArticle 31279618 VALIDATED true British Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow, G12 8TA, United Kingdom Division of Cardiac Surgery, St Michael's Hospital, University of Toronto, Toronto, ON, Canada Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States Department of Cardiology, University of Minnesota, Minneapolis, United States Second Department of Internal Medicine, Cardiovascular Medicine, General Teaching Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic Department of Medicine, Saarland University Hospital, Homburg/Saar, Germany Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan National Yang-Ming University, Taipei, Taiwan Department of Cardiology, Medanta, Gurgaon, Haryana, India Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, United States Division of Cardiology, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina Department Cardiology, Medical University of Lodz, Lodz, Poland Fifth Department of Internal Medicine, Comenius University in Bratislava, Bratislava, Slovakia Shanghai Institute of Cardiovascular Disease, Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai, China Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria Cardiovascular Division of Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan Institute of Medicine, Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Heart and Vascular Center, Semmelweis University, Budapest, Hungary Instituto Do Coracao (InCor), Hospital das Clínicas Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil Department of Cardiology, Montreal Heart Institute, Montreal, ON, Canada Department of Internal Medicine, Tan Tao University, Tan Duc, Viet Nam Department of Cardiology, Gentofte University Hospital Copenhagen, Copenhagen, Denmark Department of Myocardial Disease and Heart Failure, National Medical Research Center of Cardiology, Moscow, Russian Federation Department of Cardiology Copenhagen, University Hospital, Copenhagen, Denmark St Luke's Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, United States Late Stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals RandD, AstraZeneca, Gothenburg, Sweden Universidad Nacional de Córdoba, Córdoba, Argentina Center for Heart Diseases, University Hospital, Wroclaw Medical University, Wroclaw, Poland Early Discovery and Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals RandD, AstraZeneca, Gothenburg, Sweden Clinical Pharmacology and Safety Sciences, BioPharmaceuticals RandD, AstraZeneca, Gaithersburg, MD, United States Cited By :101 Export Date: 29 September 2021 CODEN: JAMAA Correspondence Address: McMurray, J.J.V.; British Heart Foundation Cardiovascular Research Centre, 126 University Pl, United Kingdom; email: john.mcmurray@glasgow.ac.uk Chemicals/CAS: biguanide, 56-03-1; creatinine, 19230-81-0, 60-27-5; dapagliflozin, 461432-26-8; digitalis, 8031-42-3, 8053-83-6; hemoglobin A1c, 62572-11-6; insulin, 9004-10-8; sacubitril plus valsartan, 936623-90-4; glucoside, 50986-29-3; glycosylated hemoglobin, 9062-63-9; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol; Benzhydryl Compounds; Glucosides; Glycated Hemoglobin A; Hypoglycemic Agents; Placebos; Sodium-Glucose Transporter 2 Inhibitors Manufacturers: Astra Zeneca 0 false 2026-09-17T10:50:37.279+0000 2022-11-24T18:59:45.057+0000 2020-04-15T13:11:57.039+0000 true 10055096 Nagy Regina /api/admin/10055096 Admin true 10055096 2023-07-25T12:56:08.260+0000 2023-07-25T12:56:08.260+0000 2022-11-24T18:59:45.723+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Petrie, Mark C Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes. true true /api/journal/2954 REVIEWED true false 2954 false 2954 true 0098-7484 1538-3598 Journal FOREIGN 323 14 1353 1368 1353 16 2020 Additional treatments are needed for heart failure with reduced ejection fraction (HFrEF). Sodium-glucose cotransporter 2 (SGLT2) inhibitors may be an effective treatment for patients with HFrEF, even those without diabetes.To evaluate the effects of dapagliflozin in patients with HFrEF with and without diabetes.Exploratory analysis of a phase 3 randomized trial conducted at 410 sites in 20 countries. Patients with New York Heart Association classification II to IV with an ejection fraction less than or equal to 40% and elevated plasma N-terminal pro B-type natriuretic peptide were enrolled between February 15, 2017, and August 17, 2018, with final follow-up on June 6, 2019.Addition of once-daily 10 mg of dapagliflozin or placebo to recommended therapy.The primary outcome was the composite of an episode of worsening heart failure or cardiovascular death. This outcome was analyzed by baseline diabetes status and, in patients without diabetes, by glycated hemoglobin level less than 5.7% vs greater than or equal to 5.7%.Among 4744 patients randomized (mean age, 66 years; 1109 [23%] women; 2605 [55%] without diabetes), 4742 completed the trial. Among participants without diabetes, the primary outcome occurred in 171 of 1298 (13.2%) in the dapagliflozin group and 231 of 1307 (17.7%) in the placebo group (hazard ratio, 0.73 [95% CI, 0.60-0.88]). In patients with diabetes, the primary outcome occurred in 215 of 1075 (20.0%) in the dapagliflozin group and 271 of 1064 (25.5%) in the placebo group (hazard ratio, 0.75 [95% CI, 0.63-0.90]) (P value for interaction = .80). Among patients without diabetes and a glycated hemoglobin level less than 5.7%, the primary outcome occurred in 53 of 438 patients (12.1%) in the dapagliflozin group and 71 of 419 (16.9%) in the placebo group (hazard ratio, 0.67 [95% CI, 0.47-0.96]). In patients with a glycated hemoglobin of at least 5.7%, the primary outcome occurred in 118 of 860 patients (13.7%) in the dapagliflozin group and 160 of 888 (18.0%) in the placebo group (hazard ratio, 0.74 [95% CI, 0.59-0.94]) (P value for interaction = .72). Volume depletion was reported as an adverse event in 7.3% of patients in the dapagliflozin group and 6.1% in the placebo group among patients without diabetes and in 7.8% of patients in the dapagliflozin group and 7.8% in the placebo group among patients with diabetes. A kidney adverse event was reported in 4.8% of patients in the dapagliflozin group and 6.0% in the placebo group among patients without diabetes and in 8.5% of patients in the dapagliflozin group and 8.7% in the placebo group among patients with diabetes.In this exploratory analysis of a randomized trial of patients with HFrEF, dapagliflozin compared with placebo, when added to recommended therapy, significantly reduced the risk of worsening heart failure or cardiovascular death independently of diabetes status.ClinicalTrials.gov Identifier: NCT03036124. 2020 true true true false false NONE 2026-09-17 false 435 4 435 366 5 435 420 406 413 435 435 366 366 366 69 0 435 366 435 366 0 5 5 Folyóiratcikk Journal Article 24 432 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 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class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (39) </div> <div><a target="_blank" href="/api/publication/31279618?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31279618" target="_blank">Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes.</a></div> <div> <span class="journal-title">JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0098-7484">0098-7484</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1538-3598">1538-3598</a>)</span>: <span class="journal-volume">323</span> <span class="journal-issue">14</span> <span class="page"> pp 1353-1368 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1001/jama.2020.1906" target="_blank" href="https://doi.org/10.1001/jama.2020.1906"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000528583600015" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000528583600015"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85082420398" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85082420398"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32219386" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32219386&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 435</span> | Független: 366 | Függő: 69 | Nem jelölt: 0 | WoS jelölt: 406 | Scopus jelölt:&nbsp;413 | WoS/Scopus jelölt:&nbsp;435 | DOI jelölt:&nbsp;420 (Nem nyilvános:&nbsp;4) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31279618&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31279618</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2022.11.24. 19:59 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: British Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow, G12 8TA, United Kingdom Division of Cardiac Surgery, St Michael's Hospital, University of Toronto, Toronto, ON, Canada Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States Departm...</pre> </div></div>