https://m2.mtmt.hu/ eng 2026-05-31 16:23 JournalArticle 31264379 VALIDATED true * Megosztott szerzőség 0 false 2026-05-19T21:27:00.676+0000 2024-09-17T07:38:35.290+0000 2020-03-28T12:19:39.599+0000 true 10072320 Patkós Ilona /api/admin/10072320 Admin true 2025-12-22T13:42:07.973+0000 2025-12-22T13:42:07.973+0000 2024-09-17T07:38:35.601+0000 true 10073918 Kovács Marcell /api/admin/10073918 Admin true Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2024-09-09T07:21:55.189+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sághy, Éva Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 21 6 2128 2128 12 2020 Little is known about the mechanism of prediabetes-induced cardiac dysfunction. Therefore, we aimed to explore key molecular changes with transcriptomic and bioinformatics approaches in a prediabetes model showing heart failure with preserved ejection fraction phenotype. To induce prediabetes, Long-Evans rats were fed a high-fat diet for 21 weeks and treated with a single low-dose streptozotocin at week 4. Small RNA-sequencing, in silico microRNA (miRNA)-mRNA target prediction, Gene Ontology analysis, and target validation with qRT-PCR were performed in left ventricle samples. From the miRBase-annotated 752 mature miRNA sequences expression of 356 miRNAs was detectable. We identified two upregulated and three downregulated miRNAs in the prediabetic group. We predicted 445 mRNA targets of the five differentially expressed miRNAs and selected 11 mRNAs targeted by three differentially expressed miRNAs, out of which five mRNAs were selected for validation. Out of these five targets, downregulation of three mRNAs i.e., Juxtaposed with another zinc finger protein 1 (Jazf1); RAP2C, member of RAS oncogene family (Rap2c); and Zinc finger with KRAB and SCAN domains 1 (Zkscan1) were validated. This is the first demonstration that prediabetes alters cardiac miRNA expression profile. Predicted targets of differentially expressed miRNAs include Jazf1, Zkscan1, and Rap2c mRNAs. These transcriptomic changes may contribute to the diastolic dysfunction and may serve as drug targets. Funding 2016406 /api/funding/2016406 false true Funding 2016407 /api/funding/2016407 false true Funding 2016408 /api/funding/2016408 false true Funding 2016409 /api/funding/2016409 false true true true 2020 true true true false true false GOLD 2026-05-19 true https://doi.org/10.3390/ijms21062128 16 0 15 7 10 15 16 14 15 15 15 7 7 7 9 0 16 7 15 7 0 6 6 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 1 0 1 0 2021 0 5 1 5 1 2022 0 0 0 0 0 2023 0 3 2 3 2 2024 0 1 0 1 0 2025 0 5 3 5 3 2026 0 1 1 1 1 D1 false 10010125,10057401,10037547 false false false 2020-03-27T12:20:34.113+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); HCEMM-SE Kardiometabolikus Immunológia Kutatócs... (SE / AOK / I / FFI); MTA-SE Rendszerfarmakológiai Kutatócsoport (SE / AOK / I / FFI); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 9 34 4 10 0 true 10073918 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 91315468 /api/authorship/91315468 1 0.1 true false false Author 10037547 /api/author/10037547 Sághy Éva true 10037547 true Sághy Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315469 /api/authorship/91315469 2 0.1 true false false Author 10065328 /api/author/10065328 Vörös Imre true 10065328 true Vörös Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315470 /api/authorship/91315470 3 0.1 false false false Author 10057401 /api/author/10057401 Ágg Bence true 10057401 true Ágg Bence true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315471 /api/authorship/91315471 4 0.1 false false false Author 10064374 /api/author/10064374 Kiss Bernadett true 10064374 true Kiss Bernadett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315472 /api/authorship/91315472 5 0.1 false false false Author 10040913 /api/author/10040913 Koncsos Gábor true 10040913 true Koncsos Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315473 /api/authorship/91315473 6 0.1 false false false Author 10028393 /api/author/10028393 Varga Zoltán true 10028393 true Varga Zoltán V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315474 /api/authorship/91315474 7 0.1 false false false Author 10027602 /api/author/10027602 Görbe Anikó true 10027602 true Görbe Anikó true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315475 /api/authorship/91315475 8 0.1 false false false Author 10026898 /api/author/10026898 Giricz Zoltán true 10026898 true Giricz Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315476 /api/authorship/91315476 9 0.1 false true false Schulz Rainer true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91315477 /api/authorship/91315477 10 0.1 false true true Author 10010125 /api/author/10010125 Ferdinandy Péter true 10010125 true Ferdinandy Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16804521 /api/publicationidentifier/16804521 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms21062128 https://doi.org/10.3390/ijms21062128 false true PublicationIdentifier 16937793 /api/publicationidentifier/16937793 PlainSource 1 /api/publicationsource/1 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/api/publicationidentifier/16822787 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 32244869 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32244869&dopt=Abstract false true Classification 10612 /api/classification/10612 true true SjrRating 10770268 /api/sjrrating/10770268 57 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1706 /api/classificationexternal/1706 true 1706 true D1 DIRECT true true /api/publication/31264379 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10037547"><a href="/gui2/?type=authors&mode=browse&sel=10037547" target="_blank">Sághy Éva (<span class="authorship-author-name">Sághy Éva</span> <span class="authorAux-mtmt"> Gyógyszertudományok, farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE System Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065328"><a href="/gui2/?type=authors&mode=browse&sel=10065328" target="_blank">Vörös Imre<sup>*</sup> (<span class="authorship-author-name">Vörös Imre</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE System Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057401"><a href="/gui2/?type=authors&mode=browse&sel=10057401" target="_blank">Ágg Bence (<span class="authorship-author-name">Ágg Bence</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE System Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064374"><a href="/gui2/?type=authors&mode=browse&sel=10064374" target="_blank">Kiss Bernadett (<span class="authorship-author-name">Kiss Bernadett</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE System Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040913"><a href="/gui2/?type=authors&mode=browse&sel=10040913" target="_blank">Koncsos Gábor (<span class="authorship-author-name">Koncsos Gábor</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V. (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027602"><a href="/gui2/?type=authors&mode=browse&sel=10027602" target="_blank">Görbe Anikó (<span class="authorship-author-name">Görbe Anikó</span> <span class="authorAux-mtmt"> orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE System Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026898"><a href="/gui2/?type=authors&mode=browse&sel=10026898" target="_blank">Giricz Zoltán (<span class="authorship-author-name">Giricz Zoltán</span> <span class="authorAux-mtmt"> Biokémia, Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter ✉ (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE System Pharmacology Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31264379" target="_blank">Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">21</span> <span class="journal-issue">6</span> <span class="page"> Paper 2128. 12 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms21062128" target="_blank" href="https://doi.org/10.3390/ijms21062128"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000529890200224" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000529890200224"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="114575" target="_blank" href="http://real.mtak.hu/114575"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85082590109" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85082590109"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32244869" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32244869&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 16</span> | Independent citation: 7 | Self citation: 9 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;15 | WoS/Scopus assigned:&nbsp;15 | Number of citations with DOI:&nbsp;16 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31264379&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31264379</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Heart Program(NVKP-16-1-2016-0017) Funder: NRDIO, (OTKA KH 125570) Funder: NRDIO, (János Bolyai Research Scholarship), (ÚNKP-19-4) </div> <div class="lastModified">Last Modified: 2024.09.17. 09:38 Marcell Kovács (MTMT Közp., admin) </div> <div class="lockedBy">Centrally managed 2024.09.09. 09:21 Marcell Kovács (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: * Megosztott szerzőség</pre> </div></div>