{ "labelLang" : "hun", "responseDate" : "2024-03-28 13:17", "content" : { "otype" : "JournalArticle", "mtid" : 31262762, "status" : "VALIDATED", "published" : true, "comment" : "Funding Agency and Grant Number: UCSI University Research Grant Scheme [Proj-In-FMS-008]\n Funding text: This research was funded by UCSI University Research Grant Scheme Proj-In-FMS-008.\nExport Date: 27 March 2020 \n CODEN: MOLEF \n Correspondence Address: Cheah, S.-C.; Faculty of Medicine and Health Sciences, UCSI UniversityMalaysia; email: cheahsc@ucsiuniversity.edu.my\nCited By :1 \n Export Date: 7 September 2020 \n CODEN: MOLEF \n Correspondence Address: Cheah, S.-C.; Faculty of Medicine and Health Sciences, UCSI UniversityMalaysia; email: cheahsc@ucsiuniversity.edu.my\nCited By :3 \n Export Date: 20 May 2021 \n CODEN: MOLEF \n Correspondence Address: Cheah, S.-C.; Faculty of Medicine and Health Sciences, Malaysia; email: cheahsc@ucsiuniversity.edu.my", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2021-05-20T09:38:03.102+0000", "lastModified" : "2020-03-27T08:21:29.512+0000", "created" : "2020-03-27T08:17:37.614+0000", "creator" : { "otype" : "Admin", "mtid" : 10045349, "link" : "/api/admin/10045349", "label" : "Fekete Rita (PTE GYTK admin 5)", "familyName" : "Fekete", "givenName" : "Rita", "published" : true, "oldId" : 10045349, "snippet" : true }, "lastDuplumSearch" : "2022-07-27T11:10:49.060+0000", "validated" : "2020-03-27T08:21:29.526+0000", "validator" : { "otype" : "Admin", "mtid" : 10045349, "link" : "/api/admin/10045349", "label" : "Fekete Rita (PTE GYTK admin 5)", "familyName" : "Fekete", "givenName" : "Rita", "published" : true, "oldId" : 10045349, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Heng, Win Sen", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 91309302, "link" : "/api/authorship/91309302", "label" : "Heng, Win Sen", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Heng", "givenName" : "Win Sen", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 91309303, "link" : "/api/authorship/91309303", "label" : "Cheah, Shiau-Chuen ✉", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Cheah", "givenName" : "Shiau-Chuen", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Chelerythrine Chloride Downregulates beta-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 16800294, "link" : "/api/publicationidentifier/16800294", "label" : "DOI: 10.3390/molecules25010224", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.3390/molecules25010224", "realUrl" : "https://doi.org/10.3390%2Fmolecules25010224", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16800295, "link" : "/api/publicationidentifier/16800295", "label" : "WoS: 000513770000224", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=@@@&DestApp=WOS", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000513770000224", "realUrl" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000513770000224&DestApp=WOS", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16800323, "link" : "/api/publicationidentifier/16800323", "label" : "Scopus: 85077600723", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85077600723", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85077600723", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16800296, "link" : "/api/publicationidentifier/16800296", "label" : "PubMed: 31935827", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "idValue" : "31935827", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31935827&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 25013, "link" : "/api/journal/25013", "label" : "MOLECULES 1420-3049 1420-3049", "pIssn" : "1420-3049", "eIssn" : "1420-3049", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 25013, "snippet" : true }, "volume" : "25", "issue" : "1", "internalId" : "224", "firstPageOrInternalIdForSort" : "224", "pageLength" : 15, "publishedYear" : 2020, "abstractText" : "Plant secondary metabolites have been seen as alternatives to seeking new medicines for treating various diseases. Phytochemical scientists remain hopeful that compounds isolated from natural sources could help alleviate the leading problem in oncology-the lung malignancy that kills an estimated two million people annually. In the present study, we characterized a medicinal compound benzophenanthridine alkaloid, called chelerythrine chloride for its anti-tumorigenic activities. Cell viability assays confirmed its cytotoxicity and anti-proliferative activity in non-small cell lung carcinoma (NSCLC) cell lines. Immunofluorescence staining of beta-catenin revealed that there was a reduction of nuclear content as well as overall cellular content of beta-catenin after treating NCI-H1703 with chelerythrine chloride. In functional characterizations, we observed favorable inhibitory activities of chelerythrine chloride in cancer stem cell (CSC) properties, which include soft agar colony-forming, migration, invasion, and spheroid forming abilities. Interesting observations in chelerythrine chloride treatment noted that its action abides to certain concentration-specific-targeting behavior in modulating beta-catenin expression and apoptotic cell death. The downregulation of beta-catenin implicates the downregulation of CSC transcription factors like SOX2 and MYC. In conclusion, chelerythrine chloride has the potential to mitigate cancer growth due to inhibitory actions toward the tumorigenic activity of CSC in lung cancer and it can be flexibly adjusted according to concentration to modulate specific targeting in different cell lines.", "keywords" : [ { "otype" : "Keyword", "mtid" : 300, "link" : "/api/keyword/300", "label" : "APOPTOSIS", "published" : true, "oldId" : 300, "snippet" : true }, { "otype" : "Keyword", "mtid" : 300, "link" : "/api/keyword/300", "label" : "APOPTOSIS", "published" : true, "oldId" : 300, "snippet" : true }, { "otype" : "Keyword", "mtid" : 643, "link" : "/api/keyword/643", "label" : "CANCER", "published" : true, "oldId" : 643, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1344, "link" : "/api/keyword/1344", "label" : "INDUCTION", "published" : true, "oldId" : 1344, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1652, "link" : "/api/keyword/1652", "label" : "GROWTH", "published" : true, "oldId" : 1652, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1663, "link" : "/api/keyword/1663", "label" : "DEATH", "published" : true, "oldId" : 1663, "snippet" : true }, { "otype" : "Keyword", "mtid" : 12382, "link" : "/api/keyword/12382", "label" : "emergence", "published" : true, "oldId" : 12382, "snippet" : true }, { "otype" : "Keyword", "mtid" : 13094, "link" : "/api/keyword/13094", "label" : "FATE", "published" : true, "oldId" : 13094, "snippet" : true }, { "otype" : "Keyword", "mtid" : 19546, "link" : "/api/keyword/19546", "label" : "lung cancer", "published" : true, "oldId" : 19546, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1002121, "link" : "/api/keyword/1002121", "label" : "NATURAL-PRODUCTS", "published" : true, "oldId" : 1002121, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1049275, "link" : "/api/keyword/1049275", "label" : "alternative medicine", "published" : true, "oldId" : 1049275, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1493330, "link" : "/api/keyword/1493330", "label" : "Biochemistry & Molecular Biology", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1512058, "link" : "/api/keyword/1512058", "label" : "GLYCOGEN-SYNTHASE KINASE-3-BETA", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1534298, "link" : "/api/keyword/1534298", "label" : "dosing", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1575282, "link" : "/api/keyword/1575282", "label" : "Natural compound", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1580139, "link" : "/api/keyword/1580139", "label" : "Wnt inhibitor", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2002800, "link" : "/api/keyword/2002800", "label" : "herbal compound", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2020, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2021-05-20", "oaFree" : false, "oaLink" : "http://www.mdpi.com/journal/molecules", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10872181, "link" : "/api/sjrrating/10872181", "label" : "sjr:Q1 (2020) Scopus - Pharmaceutical Science MOLECULES 1420-3049 1420-3049", "listPos" : 44, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 3003, "link" : "/api/classificationexternal/3003", "label" : "Scopus - Pharmaceutical Science", "published" : true, "oldId" : 3003, "snippet" : true }, "ranking" : "Q1", "calculation" : "FROM_LAST_YEAR", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2020-03-26T08:21:29.378+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 11, "ownerInstituteCount" : 27, "directInstituteCount" : 0, "authorCount" : 2, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/31262762", "label" : "Heng Win Sen et al. Chelerythrine Chloride Downregulates beta-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma. (2020) MOLECULES 1420-3049 1420-3049 25 1", "template" : "