https://m2.mtmt.hu/ hun 2026-09-20 19:46 JournalArticle 31261197 VALIDATED true Export Date: 09 April 2025; Cited By: 203; Correspondence Address: Z. Ungvari; Oklahoma Center for Geroscience, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, United States; email: zoltan-ungvari@ouhsc.edu; CODEN: JACCD 0 false 2026-09-08T07:42:43.726+0000 2024-12-06T17:54:53.652+0000 2020-03-26T09:04:10.020+0000 true 10055096 Nagy Regina /api/admin/10055096 Admin true 10055096 2026-07-30T09:06:30.952+0000 2024-12-06T17:54:54.039+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Ungvari, Zoltan Mechanisms of Vascular Aging, A Geroscience Perspective JACC Focus Seminar true true /api/journal/2211 REVIEWED true false 2211 false 2211 true 0735-1097 1558-3597 Journal FOREIGN 75 8 931 941 931 11 2020 Age-related pathological alterations of the vasculature have a critical role in morbidity and mortality of older adults. In epidemiological studies, age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. To develop novel therapeutic interventions for prevention of age-related vascular pathologies, it is crucial to understand the cellular and molecular mechanisms of vascular aging. In this review, shared molecular mechanisms of aging are considered in terms of their contribution to the pathogenesis of macrovascular and microvascular diseases associated with old age. The role of cellular senescence in development of vascular aging phenotypes is highlighted, and potential interventions to prevent senescence and to eliminate senescent cells for prevention of vascular pathologies are presented. The evidence supporting a role for interorgan communication and circulating progeronic and antigeronic factors in vascular aging is discussed. true true 2020 true true true false true false NONE 2026-09-08 false 315 0 315 276 46 313 313 283 311 315 315 276 276 276 39 0 315 276 315 276 0 18 18 Folyóiratcikk Journal Article 24 311 Könyvrészlet Chapter in Book 25 4 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 5 5 5 5 2021 0 27 24 27 24 2022 0 45 42 45 42 2023 0 49 41 49 41 2024 0 57 50 57 50 2025 0 83 67 83 67 2026 0 49 47 49 47 D1 false false false false 2020-06-24T08:05:46.065+0000 Doktori Iskola (SE); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Népegészségtani Intézet (SE / AOK / I); Sportorvostan Tanszék (SE / AOK / K); Transzlációs Medicina Intézet (SE / AOK / I); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 4 55 6 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 91303917 /api/authorship/91303917 1 0.2 true false true Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91303918 /api/authorship/91303918 2 0.2 false false false Author 10074557 /api/author/10074557 Tarantini Stefano true true Tarantini Stefano true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91303919 /api/authorship/91303919 3 0.2 false false false Sorond Farzaneh true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91303920 /api/authorship/91303920 4 0.2 false false false Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Bela true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91303921 /api/authorship/91303921 5 0.2 false true false Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16796571 /api/publicationidentifier/16796571 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.jacc.2019.11.061 https://doi.org/10.1016/j.jacc.2019.11.061 false true PublicationIdentifier 16796572 /api/publicationidentifier/16796572 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000516839400012 https://www.webofscience.com/wos/woscc/full-record/000516839400012 false true PublicationIdentifier 16864905 /api/publicationidentifier/16864905 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85079542496 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85079542496 false true PublicationIdentifier 16796570 /api/publicationidentifier/16796570 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 32130929 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32130929&dopt=Abstract false true Classification 12124 /api/classification/12124 true true Keyword 308 /api/keyword/308 true 308 true Keyword 1828 /api/keyword/1828 true 1828 true Keyword 14195 /api/keyword/14195 true 14195 true Keyword 1014859 /api/keyword/1014859 true 1014859 true Keyword 1576333 /api/keyword/1576333 true true SjrRating 10758712 /api/sjrrating/10758712 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/31261197 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan ✉ (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sorond Farzaneh </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Bela (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31261197" target="_blank">Mechanisms of Vascular Aging, A Geroscience Perspective : JACC Focus Seminar.</a></div> <div> <span class="journal-title">JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0735-1097">0735-1097</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1558-3597">1558-3597</a>)</span>: <span class="journal-volume">75</span> <span class="journal-issue">8</span> <span class="page"> pp 931-941 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.jacc.2019.11.061" target="_blank" href="https://doi.org/10.1016/j.jacc.2019.11.061"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000516839400012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000516839400012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85079542496" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85079542496"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32130929" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32130929&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 315</span> | Független: 276 | Függő: 39 | Nem jelölt: 0 | WoS jelölt: 283 | Scopus jelölt:&nbsp;311 | WoS/Scopus jelölt:&nbsp;315 | DOI jelölt:&nbsp;313 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31261197&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 18 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31261197</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2024.12.06. 18:54 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 09 April 2025; Cited By: 203; Correspondence Address: Z. Ungvari; Oklahoma Center for Geroscience, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, United States; email: zoltan-ungvari@ouhsc.edu; CODEN: JACCD</pre> </div></div>