Psoriasis is an inflammatory disease that changes plasma composition, and it is detectable
by differential scanning calorimetry (DSC). Besides the general change in plasma,
the aim of the study was to demonstrate which components are changing and how the
anti-psoriatic drug treatment affects back all this. Retrospectively, blood plasma
DSC data were analyzed from patients, who have different severities of symptoms and
who received steroids (n = 10), or retinoids (n = 10), or biological drug treatment
(n = 10). Complex curves were deconvoluted in several individual transitions (T-m1-T-m5),
modeling each individual transition. In the examined psoriasis stages, the thermodynamic
parameters excess heat capacity and enthalpy of the transitions in proportion corresponded
to the targeted treatment and the degree of disease severity, as well as the numbers
of transitions were determined from the calorimetric profiles. In conclusion, deconvoluted
plasma DSC profiles showed similarities but exhibited marked differences in the thermal
denaturation on different treated psoriasis stages. This examination has shown that
drug therapy affects the composition of plasma proteins, which should be always considered
for the evaluation of DSC results in similar studies.
