MicroRNAs, the endogenous mediators of RNA interference, interact with the renin-angiotensin-aldosterone
system, regulate aldosterone secretion and aldosterone effects. Some novel data show
that the expression of some microRNAs is altered in primary aldosteronism, and some
of these appear to have pathogenic relevance, as well. Differences in the circulating
microRNA expression profiles between the two major forms of primary aldosteronism,
unilateral aldosterone-producing adenoma and bilateral adrenal hyperplasia have also
been shown. Here, we present a brief synopsis of these findings focusing on the potential
relevance of microRNA in primary aldosteronism.
